Site-Specific Incorporation of Novel Backbone Structures into Proteins
Ellman J, Mendel D, Schultz P. Site-Specific Incorporation of Novel Backbone Structures into Proteins. Science 1992, 255: 197-200. PMID: 1553546, DOI: 10.1126/science.1553546.Peer-Reviewed Original ResearchConceptsAmino acidsProtein biosynthetic machineryT4 lysozymeBroad substrate specificitySite-specific incorporationUnnatural amino acidsBiosynthetic machineryProtein stabilitySubstrate specificityAmino acid analoguesN-alkyl amino acidsNovel backbone structuresAlpha-disubstituted amino acidsBackbone structureStructural perturbationsSide-chain substitutionAcid analoguesAcidMachineryProteinLysozymeAlanineLactic acidWide range
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