2017
L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level
Jamwal S, Singh S, Gill JS, Kumar P. L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level. European Journal Of Pharmacology 2017, 811: 171-179. PMID: 28624333, DOI: 10.1016/j.ejphar.2017.06.016.Peer-Reviewed Original ResearchConceptsStriatal neurotransmitter levelsOxido-nitrosative stressNeurotransmitter levelsProtective effectL-NAMEMotor deficitsQuinolinic acidL-arginineL-theanineNitric oxide synthase inhibitorPro-inflammatory cytokinesNitric oxide pathwayOxide synthase inhibitorOpen field testL-theanine treatmentRota-rodBeam walkingNeuro-inflammationNeurotransmitter alterationsNeuroprotective potentialStriatal neurotoxicityOxide pathwayQA injectionGrip strengthMotor coordination
2015
Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury
Gao Y, Xu S, Cui Z, Zhang M, Lin Y, Cai L, Wang Z, Luo X, Zheng Y, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C. Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury. Journal Of Neurochemistry 2015, 134: 340-353. PMID: 25872793, DOI: 10.1111/jnc.13123.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryGlutamate carboxypeptidase IIModerate traumatic brain injuryNeurotransmitter N-acetylaspartylglutamateGCPII geneBrain injuryNervous systemSpatial learning/memoryEnhanced glutamate transmissionLong-term behavioral outcomesHippocampus 24 hInhibition of GCPIIWild-type littermatesMorris water mazeCarboxypeptidase IIKO mouse lineLearning/memoryHistopathological protectionGene KOBeam walkingGlutamate transmissionNeuronal degenerationAstrocyte damageKO miceNeurological behavior
2014
Microglial CX3CR1 required for M2 polarization and recovery after intracerebral hemorrhage (INC5P.322)
Taylor R, Hammond M, Ai Y, Sansing L. Microglial CX3CR1 required for M2 polarization and recovery after intracerebral hemorrhage (INC5P.322). The Journal Of Immunology 2014, 192: 120.2-120.2. DOI: 10.4049/jimmunol.192.supp.120.2.Peer-Reviewed Original ResearchIntracerebral hemorrhageBeam walkingWT microgliaIntracellular stainingCX3CR1GFP/GFP miceHigher CD36 expressionActivation of microgliaBone marrow chimerasBrain rupturesMicroglial CX3CR1IL-10WT micePerihematomal regionMonocyte subsetsIL-4Right striatumChemokine receptorsM1 phenotypeM2 polarizationM2 phenotypeMicrogliaCD36 expressionBone marrowNull miceGFP mice
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