2019
Identification of the kinase STK25 as an upstream activator of LATS signaling
Lim S, Hermance N, Mudianto T, Mustaly H, Mauricio I, Vittoria M, Quinton R, Howell B, Cornils H, Manning A, Ganem N. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nature Communications 2019, 10: 1547. PMID: 30948712, PMCID: PMC6449379, DOI: 10.1038/s41467-019-09597-w.Peer-Reviewed Original ResearchConceptsHippo signalingHippo pathwayHippo tumor suppressor pathwayTranscriptional co-activator YAPActivation loop phosphorylationCo-activator YAPCore pathway componentsYAP/TAZ activationTumor suppressor pathwayKey unresolved questionLoop phosphorylationHippo activationPhosphorylation eventsHydrophobic motifTissue homeostasisTAZ activationUpstream activatorKinase activatorPathway componentsSuppressor pathwaySTK25Human cancersFunctional inactivationCellular proliferationSignaling
2012
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16107-16112. PMID: 22988085, PMCID: PMC3479536, DOI: 10.1073/pnas.1214447109.Peer-Reviewed Original ResearchConceptsP21-activated kinasePhosphorylated activation loopActivation loop phosphorylationCritical proline residueRho family GTPasesBcl-2/BclCellular morphological changesPAK regulationStructure-guided approachLoop phosphorylationPseudosubstrate regionAutoinhibitory pseudosubstratePseudosubstrate motifActivation loopCatalytic domainSrc SH3Cell motilityMolecular basisProline residuesKey effectorsCell deathPAK4SH3KinasePseudosubstrate
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