2022
Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction
Jiang K, Tu Z, Chen K, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y. Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction. Journal Of Clinical Investigation 2022, 132: e151268. PMID: 34752417, PMCID: PMC8718151, DOI: 10.1172/jci151268.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGasdermin DInfarcted heartMyocardial infarctionBone marrow transplantation studiesAMI mouse modelIL-1β releaseMarrow transplantation studiesReduced heart failureBlood leukocytosisDetrimental immunopathologyEarly mobilizationHeart failureInfarct sizePatient survivalVentricular remodelingCardiac functionAMI survivalMouse modelHeart functionExcessive boneNeutrophil productionNeutrophil generationScar sizePharmacological inhibition
2017
Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions
Sîrbulescu R, Boehm C, Soon E, Wilks M, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin M, Fakhri G, Orgill D, Sluder A, Poznansky M. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair And Regeneration 2017, 25: 774-791. PMID: 28922523, PMCID: PMC5760362, DOI: 10.1111/wrr.12584.Peer-Reviewed Original ResearchConceptsB cell treatmentB cellsKinetics of neutrophil infiltrationImmune cell populationsNaive B cellsWild-type miceSaline-treated controlsMature B cellsGrowth-associated protein 43Wound healingIncreased collagen depositionDiabetic murine woundsObese diabetic micePro-healing responseIncreased fibroblast proliferationWound granulation tissueT cellsIncreased relative expressionNeutrophil infiltrationLive B cellsScar sizeDiabetic miceDecreased apoptosisTopical applicationMMP2 expressionTreatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma
Kim JW, Aziz HA, McGovern K, Zolfaghari E, Jubran RF, Murphree AL, Berry JL. Treatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma. Ophthalmology Retina 2017, 1: 361-368. PMID: 31047562, PMCID: PMC7448755, DOI: 10.1016/j.oret.2017.01.014.Peer-Reviewed Original ResearchGlobe salvage rateGroup B tumorsTumor sizeB tumorsChorioretinal scarsSalvage rateTreatment outcomesPosterior fundusSingle-institution retrospective chart reviewScar sizeOverall globe salvage rateInitial laser treatmentMedian percent reductionRetrospective chart reviewGroup B eyesEnd of treatmentVertical diameterOriginal tumor sizeFinal scar sizeAssociation of timingLaser treatmentPerifoveal lesionsSystemic chemoreductionSystemic chemotherapyChart review
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