Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy
Kara F, Tosakulwong N, Lesnick T, Fought A, Kendell-Thomas J, Kapoor E, Faubion L, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy. Menopause The Journal Of The North American Menopause Society 2024, 32: 12-22. PMID: 39729067, PMCID: PMC11896108, DOI: 10.1097/gme.0000000000002481.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyMenopausal hormone therapyBaseline blood pressureWhite matter hyperintensityBlood pressureHormone therapySD age of participantsPeriventricular white matter hyperintensityLower CVD riskDiastolic blood pressureCVD risk factorsObservational follow-upAssociation of blood pressureRisk of white matter hyperintensityWMH volumeAssociation of systolicAssociated with greater WMH volumeDouble-blindPostmenopausal womenGreater WMH volumeSD ageAge of participantsFollow-upMenopausal womenElevated BP
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