Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome
Whitaker KJ, Vértes PE, Romero-Garcia R, Váša F, Moutoussis M, Prabhu G, Weiskopf N, Callaghan MF, Wagstyl K, Rittman T, Tait R, Ooi C, Suckling J, Inkster B, Fonagy P, Dolan RJ, Jones PB, Goodyer IM, Bullmore E, Goodyer I, Bullmore E, Dolan R, Fonagy P, Jones P, Fletcher P, Suckling J, Weiskopf N, Fearon P, Inkster B, Prabhu G, Bernal-Casas D, Eldar E, Ganguly T, Hauser T, Ioannidis K, Lewis G, Mita A, Moutoussis M, Neufeld S, Polek-MacDaeid E, Romero-Garcia R, St Clair M, Tait R, Toseeb U, van Harmelen A, Vértes P, Whitaker K, Will G, Ziegler G, Zimbron J, Haarsma J, Davies S, Griffin J, Hart M, Váša F, Wagstyl K, Ooi C, Widmer B, Alrumaithi A, Birt S, Cleridou K, Dadabhoy H, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Knight C, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Stribling A, Bhatti J, Hubbard N, Ilicheva N, Kentell M, Wallis B, Villis L. Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9105-9110. PMID: 27457931, PMCID: PMC4987797, DOI: 10.1073/pnas.1601745113.Peer-Reviewed Original ResearchConceptsCortical myelinationCortical areasAssociation cortical areasPrimary cortical areasBrain anatomical networksAge-related increaseCourse of adolescenceHuman brain maturationIntracortical myelinationProjection neuronsSchizophrenia-related genesCortical thicknessHigh incidenceBrain maturationAssociation cortexHuman brain structureHuman brain connectomeMyelinationBrain structuresCortical consolidationSame transcriptional profileAnatomical networksGene expression profilesBehavioral changesAdolescence
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