Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging.
Wu J, Li B, Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Li S, Huang Y, Guo T, Dai W, Xiang W, Chen W, Yang D, Zhao J, Guan Y, Xie F. Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging. Radiology 2024, 313: e233019. PMID: 39560478, PMCID: PMC11605102, DOI: 10.1148/radiol.233019.Peer-Reviewed Original ResearchConceptsP-tau-181Alzheimer's diseaseAD-related pathologyAmyloid-bPhosphor-tauTau pathologySynaptic densityTau accumulationSynaptic lossTauTau-PETDecreased synaptic densityGlial fibrillary acidic proteinPlasma glial fibrillary acidic proteinCortical thicknessAcidic proteinFibrillary acidic proteinRuijin HospitalProspective studyRelationship of plasmaBlood assayBlood markersPET/MRIBrain PET imagingPET imagingUromodulin and progression of IgA nephropathy
Chen Z, Xu L, Du W, Ouyang Y, Gu X, Fang Z, Yu X, Li J, Xie L, Jin Y, Ma J, Wang Z, Pan X, Zhang W, Ren H, Wang W, Chen X, Zhou X, Zhang H, Chen N, Xie J. Uromodulin and progression of IgA nephropathy. Clinical Kidney Journal 2024, 17: sfae209. PMID: 39145144, PMCID: PMC11322676, DOI: 10.1093/ckj/sfae209.Peer-Reviewed Original ResearchEnd-stage renal diseaseSingle-nucleotide polymorphismsIgAN patientsAllele-specific enhancer activityKidney functionAssociated with renal function deteriorationGenome-wide association studiesFunction of genetic variationBiopsy-proven IgAN patientsProgression of IgA nephropathyRenal pathological dataEnd-stage renal disease patientsRenal function deteriorationTubular epithelial cellsEnhanced activityRenal tubular epitheliumIgAN progressionUromodulin expressionNo significant differenceGenetic variationRuijin HospitalUromodulin levelsPathological dataIgA nephropathyRenal disease
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