Connectome-based models can predict early symptom improvement in major depressive disorder
Ju Y, Horien C, Chen W, Guo W, Lu X, Sun J, Dong Q, Liu B, Liu J, Yan D, Wang M, Zhang L, Guo H, Zhao F, Zhang Y, Shen X, Constable RT, Li L. Connectome-based models can predict early symptom improvement in major depressive disorder. Journal Of Affective Disorders 2020, 273: 442-452. PMID: 32560939, DOI: 10.1016/j.jad.2020.04.028.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSymptom improvementAntidepressant treatmentMDD patientsDepressive disorderTreatment outcomesEarly symptom improvementIndividual therapeutic responseInitial MR scansUntreated MDD patientsResting-state functional connectivity patternsFirst-line treatmentThree-month time pointTime pointsAntidepressant treatment outcomeBaseline functional connectivityHamilton Rating ScaleSeverity of depressionResting-state connectivityFunctional connectivity patternsResting-state fMRI dataDifferent time pointsTherapeutic responseClinical practiceFunctional brain networksConservative and disruptive modes of adolescent change in human brain functional connectivity
Váša F, Romero-Garcia R, Kitzbichler M, Seidlitz J, Whitaker K, Vaghi M, Kundu P, Patel A, Fonagy P, Dolan R, Jones P, Goodyer I, Vértes P, Bullmore E, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R. Conservative and disruptive modes of adolescent change in human brain functional connectivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 3248-3253. PMID: 31992644, PMCID: PMC7022153, DOI: 10.1073/pnas.1906144117.Peer-Reviewed Original ResearchConceptsFunctional connectivityAdolescent changesFunctional MRIMaturational indexAutobiographical memory taskHuman brain organizationSubcortical regionsResting-state oscillationsHuman brain functional connectivityHuman brain functionBaseline functional connectivityCortical surface expansionBrain functional connectivitySocial cognitionMemory taskAge-related changesBrain organizationAssociation cortexHealthy adolescentsDevelopmental changesCortical regionsBrain functionConservative developmentAerobic glycolysisSubcortical areas
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