2021
Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity
Doyle D, Lam M, Qalieh A, Qalieh Y, Sorel A, Funk O, Kwan K. Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2100686118. PMID: 34011608, PMCID: PMC8166177, DOI: 10.1073/pnas.2100686118.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnimalsCerebral CortexChromatinConnectomeCorpus CallosumDNA-Binding ProteinsFaceGene DeletionGene Expression RegulationGray MatterHand Deformities, CongenitalHumansIntellectual DisabilityLoss of Function MutationMiceMice, TransgenicMicrognathismNeckNeural PathwaysNeuronsThalamusTranscription FactorsVibrissaeWhite MatterConceptsSubplate neuronsCorpus callosumThalamocortical Axon TargetingNeural circuit wiringCoffin-Siris syndromeSubplate ablationThalamocortical neuronsCallosal axonsAscending axonsBarrel developmentIntracortical axonsCortical developmentCortical connectivityWhite matterAxon targetingWhisker barrelsSelective lossNeuron identityExtracellular matrixAxonsCircuit wiringFunction mutationsCallosumAxon guidanceDevelopmental disorders
2011
How do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Original Research
2008
Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development
Iwasato T, Inan M, Kanki H, Erzurumlu RS, Itohara S, Crair MC. Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development. Journal Of Neuroscience 2008, 28: 5931-5943. PMID: 18524897, PMCID: PMC2733830, DOI: 10.1523/jneurosci.0815-08.2008.Peer-Reviewed Original ResearchConceptsTC synapsesLayer IV barrel neuronsCritical period plasticityPrimary somatosensory cortexFormation of barrelsAdenylyl cyclase 1Knock-out (KO) miceType 1 adenylyl cyclaseDendritic asymmetryBarrel neuronsThalamocortical synapsesActivity-dependent mannerTrigeminal pathwayFormation of cAMPSomatosensory cortexBarrel cortexBarrel developmentSynapse maturationPresynaptic maturationBarrel hollowsTC axonsSubcortical regionsFunctional maturationMutant miceBRL mice
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