2025
Molecular characterization of Kawasaki disease subgroups using cell-free RNA profiling
Loy C, Wang H, Kim J, Shimizu C, Lenz J, Belcher E, Tremoulet A, Burns J, De Vlaminck I. Molecular characterization of Kawasaki disease subgroups using cell-free RNA profiling. Scientific Reports 2025, 15: 29799. PMID: 40813796, PMCID: PMC12354920, DOI: 10.1038/s41598-025-15843-7.Peer-Reviewed Original ResearchConceptsHeterogeneous clinical presentationKawasaki diseaseRNA profilesMolecular characterizationRNA transcript abundanceDisease subgroupsPresentation of Kawasaki diseaseClinical presentation of Kawasaki diseaseAcquired heart diseaseKawasaki disease patientsTranscript abundancePathway enrichment scoresRNA sequencingCell-free RNAEnrichment scoresKD phenotypeMitochondrial dysfunctionFebrile childrenHealthy childrenPediatric vasculitisClinical variablesClinical subgroupsDisease stratificationMolecular signaturesPlatelet activation
2012
An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity
Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity. Science Translational Medicine 2012, 4: 153ra131. PMID: 23019656, PMCID: PMC3753678, DOI: 10.1126/scitranslmed.3004186.Peer-Reviewed Original ResearchConceptsGlatiramer acetateDisease activityPatient populationFirst-line disease-modifying treatmentsMultiple sclerosis (MS) patient populationPeripheral blood mononuclear cellsMS patient populationDisease-modifying treatmentsMultiple sclerosis patientsBlood mononuclear cellsSubset of subjectsDisease courseSclerosis patientsMS subjectsMononuclear cellsInflammatory eventsTreatment responseUntreated subjectsAdditional groupHigh expressionTranscriptional signatureSubjectsRNA profilesTreatmentTranscriptional profiles
2003
Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 675-679. PMID: 12525699, PMCID: PMC141055, DOI: 10.1073/pnas.0237313100.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseMyeloid cellsUninfected microgliaInflammatory pathwaysMicroglial cellsIFN-gammaInflammatory stimuliMicrogliaInflammatory genesProtein pathologyInfectious agentsPreclinical diagnosisNeurodegenerative diseasesTransmissible spongiformDiseaseBrainPrP amyloidRNA profilesExpression profilesCellsCDNA arraysPrevious studiesInfectionDiagnosisPathology
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