2009
WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
Andikyan V, Taylor HS. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. Journal Of Cellular And Molecular Medicine 2009, 13: 4522-4531. PMID: 19017365, PMCID: PMC3107857, DOI: 10.1111/j.1582-4934.2008.00574.x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEndometrial NeoplasmsEndometriumEnhancer Elements, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenital Neoplasms, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansKidneyMullerian DuctsOvarian NeoplasmsPromoter Regions, GeneticProtein BindingRepressor ProteinsUterine Cervical NeoplasmsWT1 ProteinsConceptsHox gene expressionGene expressionHomeobox gene HOXA10HOXA10 expressionEpithelial cell typesHox genesTumor 1 geneRepressor activityHomeobox genesEpithelial enhancersTranscription factorsEmbryonic developmentRegulatory elementsExpression of WT1Enhancer activitySelective repressionRepressor elementAberrant regulationDevelopmental identityOvarian cancer cellsUterine organogenesisCell typesGenesRepressorCancer cells
2006
CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
Bhattacharjee B, Sengupta S. CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006, 354: 280-285. PMID: 16905170, DOI: 10.1016/j.virol.2006.06.018.Peer-Reviewed Original ResearchConceptsLong control regionE2 binding sitesP97 promoterCervical cancerNormal controlsAssociated with cervical cancerCytologically normal controlsIntact E2 geneHuman papillomavirus type 16Binding sitesMspI restriction digestionRegulate transcriptionRepressor activityHPV-16CaCx samplesCpG methylationControl regionIntact E2Restriction digestionE7 genesType 16E2 geneCaCxMalignant samplesSite methylation
1990
Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity
Riese D, Settleman J, Neary K, DiMaio D. Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity. Journal Of Virology 1990, 64: 944-949. PMID: 2153255, PMCID: PMC249196, DOI: 10.1128/jvi.64.2.944-949.1990.Peer-Reviewed Original ResearchConceptsRepressor proteinWild-type copy numberBovine papillomavirus type 1 genomeCopy numberViral genomeTranscriptional repressor proteinTransient expression experimentsMouse C127 cellsMutant viral DNAViral DNAType 1 genomeNumber phenotypeRepressor activityLow copy numberMethionine codonInitiation codonExpression experimentsC127 cellsGenomeCV1 cellsRepressor mutantsFoci formationColony formationCodonProtein
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