2011
Renal Cystic Disease Proteins Play Critical Roles in the Organization of the Olfactory Epithelium
Pluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ. Renal Cystic Disease Proteins Play Critical Roles in the Organization of the Olfactory Epithelium. PLOS ONE 2011, 6: e19694. PMID: 21614130, PMCID: PMC3094399, DOI: 10.1371/journal.pone.0019694.Peer-Reviewed Original ResearchConceptsRenal cystic diseaseOlfactory sensory neuronsOlfactory epitheliumCystic diseaseMutant animalsMature olfactory sensory neuronsMurine olfactory epitheliumDendritic knobsOlfactory adenylate cyclaseReceptor expressionSensory neuronsTransduction cascadeLaminar organizationDisease proteinMicrotubule architectureMKS1Syndrome 1Reduced expressionAdenylate cyclaseRT-PCRMKS3DiseaseProteinPhysiological activityObvious alterations
2009
Localization of proteins associated with renal cystic diseases to the olfactory epithelium
Pluznick J, Rodriguez‐Gil D, Mistry K, Hull M, Johnson C, Greer C, Caplan M. Localization of proteins associated with renal cystic diseases to the olfactory epithelium. The FASEB Journal 2009, 23: 796.11-796.11. DOI: 10.1096/fasebj.23.1_supplement.796.11.Peer-Reviewed Original Research
2008
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Human Molecular Genetics 2008, 17: 1505-1516. PMID: 18263604, PMCID: PMC2902289, DOI: 10.1093/hmg/ddn039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisButadienesCell ProliferationCystsDisease Models, AnimalEnzyme ActivationKidneyMAP Kinase Kinase 1MAP Kinase Kinase 2MiceMice, Mutant StrainsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NitrilesPolycystic Kidney, Autosomal DominantProtein Kinase InhibitorsTRPP Cation ChannelsConceptsCyst formationERK1/2 activationPostnatal day 21Renal cystic diseaseWeeks of birthCyst cell proliferationPolycystic kidney diseaseKinase pathwayKidney tubule cellsKidney-specific inactivationRenal failureMEK1/2 inhibitor U0126Kidney diseaseCystic diseaseMAPK/ERKMAPK/ERK activationPresence of ciliaProliferative indexCyst growthCyst expansionDay 21Tubule cellsBrdU uptakeCystic kidneysBromodeoxyuridine incorporation
1977
Gray scale ultrasonography in medullary cystic disease of the kidney and congenital hepatic fibrosis with tubular ectasia: new observations.
Rosenfield A, Siegel N, Kappelman N, Taylor K. Gray scale ultrasonography in medullary cystic disease of the kidney and congenital hepatic fibrosis with tubular ectasia: new observations. American Journal Of Roentgenology 1977, 129: 297-303. PMID: 409167, DOI: 10.2214/ajr.129.2.297.Peer-Reviewed Original ResearchConceptsCongenital hepatic fibrosisMedullary cystic diseaseCystic diseaseHepatic fibrosisUltrasound findingsGray scale ultrasound findingsTubular ectasiaBilateral renal cystic diseaseSalt-losing nephropathyHigh-level echoesUseful noninvasive methodRenal cystic diseaseGray-scale ultrasonographyRenal failureMedullary cystsPredominant lesionCentral echoesDifferential diagnosisSmall cystsCystic structuresEctasiaFibrosisEcho patternDiseaseNoninvasive methodGrey-scale ultrasound in the imaging of urinary tract disease.
Rosenfield A, Taylor K. Grey-scale ultrasound in the imaging of urinary tract disease. The Yale Journal Of Biology And Medicine 1977, 50: 335-53. PMID: 333791, PMCID: PMC2595534.Peer-Reviewed Original ResearchConceptsUrinary tract diseaseTract diseaseLower urinary tractRenal mass lesionsPelvic fluid collectionsRenal cystic diseaseSmall renal lesionsNon-invasive modalityGray-scale ultrasoundPerirenal abscessRenal abscessAdrenal lesionsAssociated lesionsRenal lesionsUrinary tractMass lesionProstatic tumorsCystic diseaseFluid collectionNormal anatomyLesionsDiseaseSpecific findingsUltrasoundAbscess
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