2023
Metagenomics harvested genus-specific single-stranded DNA-annealing proteins improve and expand recombineering in Pseudomonas species
Asin-Garcia E, Garcia-Morales L, Bartholet T, Liang Z, Isaacs F, dos Santos V. Metagenomics harvested genus-specific single-stranded DNA-annealing proteins improve and expand recombineering in Pseudomonas species. Nucleic Acids Research 2023, 51: 12522-12536. PMID: 37941137, PMCID: PMC10711431, DOI: 10.1093/nar/gkad1024.Peer-Reviewed Original ResearchConceptsPseudomonas genusMetabolic engineering effortsSynthetic biology applicationsGenetic engineering toolsGenome editing capabilitiesRelated speciesStress resistanceValuable hostBiology applicationsActive variantsEnvironmental biotechnologyDifferent PseudomonasRecombineeringPseudomonas speciesPseudomonas putidaPseudomonas fluorescensSpeciesGenusNGS analysisCharacteristics of toleranceRemarkable abilityProteinEngineering effortsPseudomonasValuable compounds
2018
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration
Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM. Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science Immunology 2018, 3 PMID: 29330161, PMCID: PMC5795617, DOI: 10.1126/sciimmunol.aal2736.Peer-Reviewed Original ResearchConceptsKey transcription factorEndothelial cellsEndogenous tissue regenerationThymic epithelial cellsTranscription factorsBMP4 pathwayThymic endothelial cellsDownstream targetsBMP4Genetic inhibitionThymocyte developmentTEC developmentEpithelial cellsKey mediatorEndogenous regenerationRemarkable abilityCritical pathwaysTissue regenerationPathwayCellsRegenerationEndogenous thymic regenerationT cell immunityPotential clinical approachThymic damage
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