2013
Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism*
Murray DS, Chinnam N, Tonthat NK, Whitfill T, Wray LV, Fisher SH, Schumacher MA. Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism*. Journal Of Biological Chemistry 2013, 288: 35801-35811. PMID: 24158439, PMCID: PMC3861631, DOI: 10.1074/jbc.m113.519496.Peer-Reviewed Original ResearchConceptsGlutamine synthetaseCatalytic conformational changesSpecific regulatory networksActive site constructionFeedback inhibition mechanismFeedback inhibitionGS isoenzymesCatalytic glutamateActive site reorganizationRegulatory networksEnzyme active siteNitrogen metabolismProduction of glutamineSpecific residuesAdjacent subunitsRegulatory mechanismsInhibitor designConformational changesConformational alterationsGram-positive pathogensCellular studiesEssential roleActive siteRegulatory stateGln
2012
Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification
Baker C, Booth L, Sorrells T, Johnson A. Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification. Cell 2012, 151: 80-95. PMID: 23021217, PMCID: PMC3519278, DOI: 10.1016/j.cell.2012.08.018.Peer-Reviewed Original ResearchConceptsProtein modularityAncestral modeConserved expression patternCis-regulatory sequencesNovel regulatory modeProtein-DNA interactionsRegulatory network structureMode of regulationTranscription regulationAncestral networksGene regulationModern speciesDifferent lineagesYeast speciesExpression patternsRegulatory stateRegulatory modeCooperative bindingType cellsRegulationSpeciesLineagesGenesDiversityDiversification
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