2025
Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery
Greenwood N, Boyer Z, Ellman J, Gnamm C. Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery. Journal Of Medicinal Chemistry 2025, 68: 4079-4100. PMID: 39787298, DOI: 10.1021/acs.jmedchem.4c02714.Peer-Reviewed Original ResearchConceptsFunctional groupsMedicinal chemist's perspectiveTraditional functional groupsChemistry toolboxMedicinal chemistryMedicinal chemistry toolboxDrug scaffoldsSulfilimineMetabolic stabilityChemist's perspectiveHNE inhibitorsDrug discoveryAnalog of imatinibPhysiologically relevant conditionsRelevant conditionsPharmacophoreChemistryPropertiesS(IVSolubilityIn vitro propertiesScaffolds
2019
Chapter Eight Illuminating the virus life cycle with single-molecule FRET imaging
Lu M, Ma X, Mothes W. Chapter Eight Illuminating the virus life cycle with single-molecule FRET imaging. Advances In Virus Research 2019, 105: 239-273. PMID: 31522706, PMCID: PMC7246055, DOI: 10.1016/bs.aivir.2019.07.004.Peer-Reviewed Original ResearchConceptsVirus life cycleMolecular mechanismsViral proteinsSingle-molecule FRETBiological moleculesPrecise molecular mechanismsFörster resonance energy transfer (FRET) imagingLife cycleConformational dynamicsReal-time imagingEnergetics of transitionsNovel antiviral therapiesStructural intermediatesConformational changesConformational statesNative stateSmFRETRelevant conditionsElegant experimental designsAsymmetric intermediatesIntermediatesViral fusionViral glycoproteinsStructural methodsIntact virions
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