Biomarkers of bone disease in persons with haemophilia
Goldscheitter G, Recht M, Sochacki P, Manco‐Johnson M, Taylor J. Biomarkers of bone disease in persons with haemophilia. Haemophilia 2020, 27: 149-155. PMID: 32856388, DOI: 10.1111/hae.13986.Peer-Reviewed Original ResearchConceptsLevels of TNF-aFVIII deficiencyCTX-1Factor VIII (FVIII)-deficient miceBone metabolismIL-10TNF-aHealthy controlsSkeletal healthBone diseaseIncreased risk of fractureMarkers of bone metabolismSevere FVIII deficiencyPlasma samplesLow bone densityCirculating cytokine levelsInterleukin (IL)-12Risk of fractureIL-10 levelsBone-related cytokinesEvaluated plasma samplesRegulate bone metabolismFVIII replacementCytokine levelsFactor deficiency
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