Our exploration in instrumentation focuses on developing cutting-edge technology, including advanced scanners, MR coils, MR peripherals, and novel optical systems.
Research
With an interdisciplinary, dynamic, and inclusive research environment Yale BioImaging is dedicated to understanding and advancing human and preclinical biomedical imaging research areas; our research can be divided into three thematic centers focused on different aspects of biomedical imaging:
- Imaging Technology
- Imaging Translation
- Data Sciences
Within each center, we are conducting research in the below areas:
Imaging Technology
Imaging Translation
Brain Our studies on brain function and structure encompass aging, substance abuse, mental health, cancer, and the complex networks within the brain.
Heart Discover our research on heart failure, vascular disease, and microvascular circulation.
Cancer Explore our research in oncology, including prostate and breast cancer. Learn about our pioneering studies on theranostics and imaging-guided treatments.
Other Diseases/Conditions We investigate a diverse range of systems and conditions, including inflammation, diabetes, endocrine disorders, and immune system function.
Data Sciences
Data Sciences Data sciences work focuses on advancements in motion correction, image reconstruction, and MR/MRSI sequencing and processing. These developments are essential for improving image quality and diagnostic precision in medical imaging.
Analysis/AI This group promotes AI/image analysis research in the Yale School of Medicine.
Selected Publications
2025
Context Matters: Sex and Social Status Impact Cocaine’s Effects on Kappa Opioid Receptors
Zakiniaeiz Y, Cosgrove K. Context Matters: Sex and Social Status Impact Cocaine’s Effects on Kappa Opioid Receptors. Biological Psychiatry 2025, 98: 584-585. PMID: 40973361, DOI: 10.1016/j.biopsych.2025.07.019.Peer-Reviewed Original ResearchGeometry-Guided Local Alignment for Multi-view Visual Language Pre-training in Mammography
Du Y, Chen L, Dvornek N. Geometry-Guided Local Alignment for Multi-view Visual Language Pre-training in Mammography. Lecture Notes In Computer Science 2025, 15965: 299-310. DOI: 10.1007/978-3-032-04978-0_29.Peer-Reviewed Original ResearchVisual language modelMulti-view image processingLanguage pre-trainingMulti-view relationshipsDeep learning methodsDomain-specific characteristicsContrastive learningNatural imagesCorrespondence learningLanguage modelLocal featuresMammography datasetGeometry guidanceLocal alignmentPre-trainingLearning methodsMedical imagesDomain differencesMultiple datasetsIndependent imagesProcessing of mammogramsSuboptimal predictionsDatasetLearningEarly detection of breast cancerEffects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans
Yang Y, Ibrahim W, Gravel P, Pittman B, Hoye J, Cool R, Sadabad F, Zheng M, Pittenger C, Gallezot J, Carson R, Huang H, Radhakrishnan R, Matuskey D. Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans. Molecular Imaging And Biology 2025, 1-7. PMID: 40938339, DOI: 10.1007/s11307-025-02047-8.Peer-Reviewed Original ResearchHigh-resolution research tomographBody mass indexPositron emission tomographyEffects of ageAnterior cingulate cortexPotential confounding effects of ageAge-related declineTwo-tissue compartment modelCingulate cortexReceptor availabilityFrontal cortexParietal cortexOlfactory cortexSubcortical regionsHealthy humansRegional VTCortexConfounding effects of ageCerebellum cortexEmission tomographyTwo-tissueMass indexHealthy individualsInsulaAssessed alterationsDopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation
Borchers L, Dan R, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, El Fakhri G, Normandin M, Pizzagalli D. Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation. Molecular Psychiatry 2025, 1-9. PMID: 40926089, DOI: 10.1038/s41380-025-03218-3.Peer-Reviewed Original ResearchResting-state functional connectivityMajor depressive disorderChildhood sexual abuseDopamine transporter availabilityDepressive disorderPathophysiology of Major Depressive DisorderStriatal dopamine transporter availabilitySexual abuseReward-related regionsSeed-based RSFCVentral tegmental areaDA dysregulationVentral striatumMDD episodeTegmental areaFrontostriatal pathwaysUnmedicated individualsChildhood maltreatmentNeuroimaging investigationsFunctional connectivityTransporter availabilityTreatment targetMRI studiesAbuseCo-occurrenceExploring seasonal fluctuations in dopamine D2/D3 receptor availability in healthy adults: A [11C]PHNO imaging study
Mayeli M, Gallezot J, Cosgrove K, Potenza M, Carson R, Matuskey D. Exploring seasonal fluctuations in dopamine D2/D3 receptor availability in healthy adults: A [11C]PHNO imaging study. Journal Of Affective Disorders 2025, 393: 120293. PMID: 40930176, DOI: 10.1016/j.jad.2025.120293.Peer-Reviewed Original ResearchDopamine D2/D3 receptor availabilityD2/D3 receptor availabilityReceptor availabilityPositron emission tomographyPositron emission tomography ligandsReceptor imaging studiesHealthy adultsImaging studiesDopaminergic markersCognitive performanceSymptomatic fluctuationsMixed-effects analysisScan dateDopamineHealthy participantsDaylight exposureBody mass indexMotor controlEmission tomographyMixed-effectsMixed-effects modelsMass indexGroup participantsSchool of MedicineHealthy individualsToward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.
Gravel P, Gu J, Wang C, Volpi T, Gallezot J, Holden D, Fowles K, Zheng M, Zhang L, Borroni E, Honer M, Gobbi L, Tamagnan G, Huang Y, Carson R. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates. Journal Of Nuclear Medicine 2025, jnumed.125.270332. PMID: 40908122, DOI: 10.2967/jnumed.125.270332.Peer-Reviewed Original ResearchGABA transporter type 1Nonhuman primatesGAT-1Brain uptakeNondisplaceable binding potentialSubcortical gray matter regionsHuman studiesG-aminobutyric acidLow brain uptakeGray matter structuresLow specific bindingConclusion:Methods:Gray matter regionsType 1Results:Neuropsychiatric disordersPET radiotracersBinding potentialGABA signalingVolume of distributionMatter structuresRhesus monkeysBlock scanningGABA receptorsMotion Management in Positron Emission Tomography/Computed Tomography and Positron Emission Tomography/Magnetic Resonance
Guo L, Liu C, Soultanidis G. Motion Management in Positron Emission Tomography/Computed Tomography and Positron Emission Tomography/Magnetic Resonance. PET Clinics 2025 PMID: 40858422, DOI: 10.1016/j.cpet.2025.07.004.Peer-Reviewed Original ResearchAxial field-of-viewLong axial field-of-viewTotal-body PET systemsMotion managementPET systemClinical positron emission tomographyMotion correctionField of viewPositron emission tomography/magnetic resonancePositron emission tomographyImage registrationData-driven motionPositron Emission Tomography/Computed TomographyEmission Tomography/Computed TomographyImage qualityPositronCorrectionTomography/Computed TomographyMotionAccuracy of motion estimationDeep learning-based methodsCorrection strategyEmission tomographyResonancePET studiesCannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Korem N, Bassir Nia A, Hillmer A, D’Souza D, Nabulsi N, Ropchan J, Huang Y, Cosgrove K, Levy I, Pietrzak R, Harpaz-Rotem I. Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study. Translational Psychiatry 2025, 15: 310. PMID: 40846835, PMCID: PMC12373994, DOI: 10.1038/s41398-025-03519-9.BooksPathophysiology of posttraumatic stress disorderEmotional numbing symptomsCB1R availabilityPosttraumatic stress disorderEndocannabinoid systemStress disorderPositron emission tomographyTrauma-exposed participantsEndocannabinoid system's rolePositron emission tomography studiesCannabinoid receptor 1Emission tomography studiesMulti-faceted disorderFear learningCB1RSymptom expressionHealthy controlsCannabinoidDisordersTomography studiesEmission tomographyPreclinical studiesSymptomsHigher levelsReceptor 1Predicting tumor recurrence site after reirradiation in head and neck cancer: a retrospective external validation of a published [18F]-FDG PET radiomic signature
Beddok A, Grogg K, Nioche C, Rozenblum L, Orlhac F, Calugaru V, Crehange G, Shih H, Marin T, Buvat I, El Fakhri G. Predicting tumor recurrence site after reirradiation in head and neck cancer: a retrospective external validation of a published [18F]-FDG PET radiomic signature. La Radiologia Medica 2025, 1-10. PMID: 40833475, DOI: 10.1007/s11547-025-02072-1.Peer-Reviewed Original ResearchHead and neck cancerPET radiomics signaturePositive predictive valueNeck cancerRadiomics signatureRecurrent head and neck cancerExternal cohortTumor recurrence siteDose escalationLocoregional failurePET radiomicsRecurrence siteMassachusetts General HospitalLIFEx softwareIndependent cohortRadiomic featuresOriginal cutoffPatientsPredictive valuePublished cutoffsPurposeThis studyCohortGeneral HospitalRecurrenceConclusionThe studyMulti-view and Multi-scale Alignment for Contrastive Language-Image Pre-training in Mammography
Du Y, Onofrey J, Dvornek N. Multi-view and Multi-scale Alignment for Contrastive Language-Image Pre-training in Mammography. Lecture Notes In Computer Science 2025, 15830: 247-262. PMID: 40995617, PMCID: PMC12456755, DOI: 10.1007/978-3-031-96625-5_17.Peer-Reviewed Original ResearchContrastive Language-Image Pre-trainingMulti-viewPre-trainingState-of-the-art baselinesMulti-view natureState-of-the-artMedical image analysisHigh-resolution imagesFine-tuning approachLanguage modelMammography datasetComputational resourcesModel sizeSupervised frameworkMulti-scaleData scarcityImage focusImage analysisMedical knowledgeImagesDatasetUnder-exploredSmall regionAn integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease
Arnsten A, Del Tredici K, Barthélemy N, Gabitto M, van Dyck C, Lein E, Braak H, Datta D. An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease. Alzheimer's & Dementia 2025, 21: e70404. PMID: 40767321, PMCID: PMC12326325, DOI: 10.1002/alz.70404.Peer-Reviewed Original ResearchBlunted Hemodynamic Response to Pharmacological Stress is Predictive of Mortality in Liver Transplant Candidates
Csecs I, Sharma A, Khungar V, Sinusas A, Possick S, Miller E, Feher A. Blunted Hemodynamic Response to Pharmacological Stress is Predictive of Mortality in Liver Transplant Candidates. Journal Of Nuclear Cardiology 2025, 102454. PMID: 40769316, DOI: 10.1016/j.nuclcard.2025.102454.Peer-Reviewed Original ResearchLiver transplant candidatesMELD scoreAssociated with mortalityRetrospective studyCardiovascular comorbiditiesLiver diseaseMedian follow-up periodTransplant candidatesResponse to pharmacological stressSingle-photon Emission Computed TomographyRegadenoson stress testingEnd-stage liver diseaseIncremental prognostic valueNuclear stress testingRetrospective cohort analysisFollow-up periodChronic liver diseaseBody mass indexCoronary artery diseaseHemodynamic responseStress testEmission Computed TomographyDiastolic blood pressurePredictive of mortalityPositron emission tomographyPET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD
Bonomi R, Naganawa M, McRiley D, Toyonaga T, LeVasseur B, Duman C, Huang Y, Matuskey D, Carson R, Pietrzak R, Girgenti M, Cosgrove K. PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD. Molecular Psychiatry 2025, 1-8. PMID: 40753309, DOI: 10.1038/s41380-025-03124-8.Peer-Reviewed Original ResearchPosttraumatic stress disorderPathophysiology of posttraumatic stress disorderNon-trauma-exposed controlsAmygdala of individualsProlonged stress modelBrain imaging studiesStress disorderRodent findingsNuclear translocation of glucocorticoid receptorTranslocation of glucocorticoid receptorHuman findingsTranslational findingsCortisol signalingAmygdalaGlucocorticoid receptorComplex disorderImaging studiesDisordersLongitudinal analysisStress modelHistone deacetylase 6Pharmacological targetsHistone deacetylasesFindingsNuclear translocationNoninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.
Matuschewski N, Sobirey R, Revzin M, Zeevi T, Gross M, Kasolowsky V, Shewarega A, Meister E, Kao T, Tefera J, Bousabarah K, Batra R, Strazzabosco M, Lin M, Gebauer B, Savic L, Duncan J, Madoff D, Zhang X, Chapiro J. Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma. Radiology 2025, 316: e242750. PMID: 40762840, PMCID: PMC12405729, DOI: 10.1148/radiol.242750.Peer-Reviewed Original ResearchComparative Study of Bone-Avid SPECT Tracers: In Search of a Diagnostic Target of Cardiac Amyloidosis
Zohora F, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Liu C, Miller E, Thorn S, Sinusas A. Comparative Study of Bone-Avid SPECT Tracers: In Search of a Diagnostic Target of Cardiac Amyloidosis. Journal Of Nuclear Cardiology 2025, 50: 102377. DOI: 10.1016/j.nuclcard.2025.102377.Peer-Reviewed Original ResearchAssessing the Threshold of Coronary Calcification on Attenuation Correction CT Acquired With Nuclear Myocardial Perfusion Imaging Which Equates to Secondary Prevention
Kyriakoulis I, Csecs I, Ahmed A, Wright C, Sinusas A, Miller E, Kokkinidis D, Feher A. Assessing the Threshold of Coronary Calcification on Attenuation Correction CT Acquired With Nuclear Myocardial Perfusion Imaging Which Equates to Secondary Prevention. Journal Of Nuclear Cardiology 2025, 50: 102303. DOI: 10.1016/j.nuclcard.2025.102303.Peer-Reviewed Original ResearchComparison Between Myocardial Scar Detection With Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging and Nuclear Myocardial Perfusion Imaging
Csecs I, Kyriakoulis I, Ahmed A, Wright C, Kokkinidis D, Sinusas A, Miller E, Feher A. Comparison Between Myocardial Scar Detection With Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging and Nuclear Myocardial Perfusion Imaging. Journal Of Nuclear Cardiology 2025, 50: 102418. DOI: 10.1016/j.nuclcard.2025.102418.Peer-Reviewed Original ResearchGadolinium enhancement cardiac magnetic resonance imagingLate gadolinium enhancement cardiac magnetic resonance imagingEnhancement cardiac magnetic resonance imagingNuclear myocardial perfusion imagingCardiac magnetic resonance imagingMyocardial perfusion imagingMyocardial scar detectionMagnetic resonance imagingLongitudinal Trends of Coronary Calcifications and Myocardial Flow Reserve in Heart Transplant Recipients
Wright C, Kiage J, Kyriakoulis I, Csecs I, Ahmed A, Liu Y, Bellumkonda L, Kokkinidis D, Sinusas A, Miller E, Feher A. Longitudinal Trends of Coronary Calcifications and Myocardial Flow Reserve in Heart Transplant Recipients. Journal Of Nuclear Cardiology 2025, 50: 102312. DOI: 10.1016/j.nuclcard.2025.102312.Peer-Reviewed Original ResearchLayered but Loaded: Prognostic Implications of Sequential Stress Imagingfor Diagnosing Coronary Artery Disease in Contemporary Practice
Ahmed A, Csecs I, Wright C, Kyriakoulis I, Kokkinidis D, Miller E, Feher A. Layered but Loaded: Prognostic Implications of Sequential Stress Imagingfor Diagnosing Coronary Artery Disease in Contemporary Practice. Journal Of Nuclear Cardiology 2025, 50: 102382. DOI: 10.1016/j.nuclcard.2025.102382.Peer-Reviewed Original ResearchFunctional connectivity in the social perception pathway at birth is linked with attention to faces at 4 months
Chawarska K, Vernetti A, Sun H, Hampson M, Li C, Macari S, Powell K, Constable R, Chang J, Ment L, Scheinost D. Functional connectivity in the social perception pathway at birth is linked with attention to faces at 4 months. Biological Psychiatry Global Open Science 2025, 100597. DOI: 10.1016/j.bpsgos.2025.100597.Peer-Reviewed Original ResearchIntrinsic functional connectivityFunctional connectivityNeural markersFamily history of autismSuperior temporal sulcusAssociated with attentionStatic facial featuresHistory of autismNo sex differencesSocial pathwaysHuman Connectome ProjectFusiform gyrusFacial cuesTemporal sulcusVentral pathwayFamilial riskSex differencesPerception pathwaysAutismConnectome ProjectSocial outcomesFamily historyFacial featuresAutism biomarkersWeeks postmenstrual ageA generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging
Xie H, Gan W, Ji W, Chen X, Alashi A, Thorn S, Zhou B, Liu Q, Xia M, Guo X, Liu Y, An H, Kamilov U, Wang G, Sinusas A, Liu C. A generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging. Medical Image Analysis 2025, 106: 103729. PMID: 40752375, PMCID: PMC12360895, DOI: 10.1016/j.media.2025.103729.Peer-Reviewed Original ResearchConceptsImage qualityNetwork re-trainingDeep learning methodsCardiac SPECT imagingLow-doseSPECT imagesContextual informationDiffusion frameworkLearning methodsConsistency strategyRe-trainingAcquisition settingsLow count levelsFine-tuningSpatial informationVariation constraintCardiac catheterization resultsImage dataMyocardial perfusion imagingCoronary artery diseaseProjection dataCatheterization resultsImage volumesScanner geometryProjective measurementsIn vivo 3D myocardial membrane potential mapping in humans using PET/MRI
Bijari F, Han P, Marin T, Lee W, Chemli Y, Gertsenshteyn I, Mounime I, Djebra Y, Chi D, Normandin M, Ma C, Fakhri G. In vivo 3D myocardial membrane potential mapping in humans using PET/MRI. EJNMMI Research 2025, 15: 93. PMID: 40715686, PMCID: PMC12297085, DOI: 10.1186/s13550-025-01287-7.Peer-Reviewed Original ResearchMembrane potentialExtracellular volume fraction measurementsExtracellular volume fraction mappingBolus-plus-infusion protocolT1 mapping sequencesVolume of distributionWritten Informed ConsentCardiac PET/MR imagingRigid image registrationHumans in vivoContrast agent injectionPET motion correctionFree breathingTracer volume of distributionImage registrationBolus injectionCardiac MRMitochondrial membrane potentialCardiac diseaseHealthy subjectsPET/MR imagingImaging studiesTreatment monitoringAgent injectionPET tracersMeasurement of brain glucose metabolism in obesity and diabetes
Hwang J, Bini J, Belfort-DeAguiar R. Measurement of brain glucose metabolism in obesity and diabetes. Diabetologia 2025, 68: 1879-1888. PMID: 40711543, PMCID: PMC12361331, DOI: 10.1007/s00125-025-06491-7.Peer-Reviewed Original ResearchConceptsBrain glucose metabolismNon-invasive neuroimaging techniquesMeasures of brain glucose metabolismGlucose metabolismNeuroimaging techniquesPathological state of diabetesPositron emission tomographyBrain imagingBrainState of diabetesEmission tomographyPathological statesPhysiological manipulationsInsulin levels[18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter S, Carson R, Huang Y, Cai Z. [18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury. Journal Of Nuclear Medicine 2025, 66: 1440-1448. PMID: 40675757, PMCID: PMC12410297, DOI: 10.2967/jnumed.124.269291.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDistribution volume ratioDiffusion tensor imagingSpinal cordRat modelDay 1SUV ratioImmunohistochemical stainingSham controlsDay 9PET imagingRat model of spinal cord injuryContusion SCI rat modelSpinal cord injury ratsModel of spinal cord injuryCord injuryWestern blottingModerate contusion injuryBrain of ratsDiffusion tensor imaging analysisPost-mortem spinal cordTraumatic spinal cord injurySCI rat modelSynaptic vesicle glycoprotein 2ACervical cordHow the brain shifts between external and internal attention
Nobre A, Gresch D. How the brain shifts between external and internal attention. Neuron 2025, 113: 2382-2398. PMID: 40675155, DOI: 10.1016/j.neuron.2025.06.013.Peer-Reviewed Original Research