2024
Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period
Scheinost D, Chang J, Brennan-Wydra E, Lacadie C, Constable R, Chawarska K, Ment L. Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period. Imaging Neuroscience 2024, 2: 1-16. DOI: 10.1162/imag_a_00201.Peer-Reviewed Original ResearchFronto-parietalDevelopmental trajectoriesImpact of maternal mental healthResting-state functional MRIWeeks postmenstrual ageInter-network connectivityIntra-network connectivityMaternal stress levelsMaternal mental healthPostmenstrual ageSalience networkFunctional MRINeurobehavioral disordersNeurodevelopmental disordersDMNMental healthThird trimesterConnectivity measuresSalienceConnectivity valuesMapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity
Pollatou A, Holland C, Stockton T, Peterson B, Scheinost D, Monk C, Spann M. Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity. Journal Of Neuroscience 2024, 44: e2363232024. PMID: 38604780, PMCID: PMC11140686, DOI: 10.1523/jneurosci.2363-23.2024.Peer-Reviewed Original ResearchFetal heart rate indicesDorsal anterior cingulate cortexAutonomic nervous systemDorsal anterior cingulate cortex functional connectivityFetal HRHeart rate variabilityBrain regionsFetal heart rate variationWeeks of postmenstrual ageAutonomic nervous system developmentFetal autonomic nervous systemFetal heart rate variabilityAutonomic regulationHeart rate indicesFetal heart rateNervous systemFunctional connectivityHeart rateAnterior cingulate cortex functional connectivityAnterior cingulate cortexChildren's language abilitiesFetal actocardiographInfant brainstemPostmenstrual ageWeeks gestation
2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score
2021
Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Constable RT, Chawarska K, Ment LR. Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age. Cerebral Cortex 2021, 32: 3289-3301. PMID: 34875024, PMCID: PMC9340393, DOI: 10.1093/cercor/bhab415.Peer-Reviewed Original ResearchConceptsWeeks of gestationFirst postnatal monthMonths of agePostnatal monthFunctional connectivityWernicke's areaWeeks postmenstrual ageLanguage networkResting-state fMRI dataPostmenstrual ageFetal onsetInterhemispheric connectionsIntrahemispheric connectionsPrimary analysisOlder infantsNeurobehavioral disordersSecondary analysisGestationCross-sectional dataMonthsBrocaUnique participantsWeeksSignificant increaseFunctional connections
2018
Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior
Spann MN, Monk C, Scheinost D, Peterson BS. Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior. Journal Of Neuroscience 2018, 38: 2877-2886. PMID: 29487127, PMCID: PMC5852665, DOI: 10.1523/jneurosci.2272-17.2018.Peer-Reviewed Original ResearchConceptsMaternal immune activationC-reactive proteinFetal heart rate variabilityNeonatal functional connectivityInterleukin-6Postmenstrual ageImmune activationSalience networkFunctional connectivityPsychiatric disordersCRP levelsEpidemiological studiesMaternal C-reactive proteinResting-state imaging dataC-reactive protein levelsMaternal CRP levelsMaternal IL-6Months postmenstrual agePrenatal maternal immune activationSame psychiatric disordersWeeks postmenstrual ageIL-6 levelsAlters functional connectivityAltered brain developmentSame gestational age