2024
315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes
SANCHEZ RANGEL E, BELFORT-DEAGUIAR R, LACADIE C, CHUNG T, SCHEINOST D, MASON G, HWANG J. 315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes. Diabetes 2024, 73 DOI: 10.2337/db24-315-or.Peer-Reviewed Original ResearchSalience networkFunctional connectivityCognitive tasksBrain responsesType 1 diabetesBrain functional connectivityResting stateMild hypoglycemiaWorking memoryBrain regionsSalienceContinuous performanceRewardBrainCounterregulatory hormonesStandard preprocessingTaskIndividual traitsMemoryPatientsHypoglycemiaT1DGradCPTStimuliAttentionMapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity
Pollatou A, Holland C, Stockton T, Peterson B, Scheinost D, Monk C, Spann M. Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity. Journal Of Neuroscience 2024, 44: e2363232024. PMID: 38604780, PMCID: PMC11140686, DOI: 10.1523/jneurosci.2363-23.2024.Peer-Reviewed Original ResearchFetal heart rate indicesDorsal anterior cingulate cortexAutonomic nervous systemDorsal anterior cingulate cortex functional connectivityFetal HRHeart rate variabilityBrain regionsFetal heart rate variationWeeks of postmenstrual ageAutonomic nervous system developmentFetal autonomic nervous systemFetal heart rate variabilityAutonomic regulationHeart rate indicesFetal heart rateNervous systemFunctional connectivityHeart rateAnterior cingulate cortex functional connectivityAnterior cingulate cortexChildren's language abilitiesFetal actocardiographInfant brainstemPostmenstrual ageWeeks gestation
2020
Connectome-based neurofeedback: A pilot study to improve sustained attention
Scheinost D, Hsu TW, Avery EW, Hampson M, Constable RT, Chun MM, Rosenberg MD. Connectome-based neurofeedback: A pilot study to improve sustained attention. NeuroImage 2020, 212: 116684. PMID: 32114151, PMCID: PMC7165055, DOI: 10.1016/j.neuroimage.2020.116684.Peer-Reviewed Original ResearchConceptsFunctional connectivityRt-fMRIReal-time functional magnetic resonance imaging (rt-fMRI) neurofeedbackWhole-brain functional connectivityClinical trial designFunctional magnetic resonance imaging (fMRI) neurofeedbackDistinct brain areasConnectome-based modelsClinical symptomsTrial designBrain areasBrain regionsSustained attentionTherapeutic toolPilot studyBrain activityFunctional connectionsSymptomsNeurofeedbackFunctional networksTraining durationAttention taskComplex functional networksPilot sample
2019
There is no single functional atlas even for a single individual: Functional parcel definitions change with task
Salehi M, Greene AS, Karbasi A, Shen X, Scheinost D, Constable RT. There is no single functional atlas even for a single individual: Functional parcel definitions change with task. NeuroImage 2019, 208: 116366. PMID: 31740342, DOI: 10.1016/j.neuroimage.2019.116366.Peer-Reviewed Original Research
2018
Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies
Fong AHC, Yoo K, Rosenberg MD, Zhang S, Li CR, Scheinost D, Constable RT, Chun MM. Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies. NeuroImage 2018, 188: 14-25. PMID: 30521950, PMCID: PMC6401236, DOI: 10.1016/j.neuroimage.2018.11.057.Peer-Reviewed Original ResearchConceptsAttention task performanceDynamic functional connectivityTask performanceIndividual differencesExecutive control brain networksFunctional connectivityFunctional brain scansAttention performanceTask conditionsAttention scoresBrain networksFMRI dataBrain regionsBetter attentionFC featuresFC matricesDFC matrixPearson's rAttentionIndividualsOne-subjectBrain scansConnectivityConnectomeCross-validation approachCerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence
Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrinsic connectivity distributionMedial prefrontal cortexTensor-based morphometryPTSD groupFunctional connectivityPrefrontal cortexPathophysiology of PTSDGray matter volumeWhole-brain connectivityKey brain regionsMiddle temporal gyrusDorsolateral prefrontal cortexDefault mode networkCentral executive networkFunctional connectivity analysisPFC alterationsCortical alterationsHealthy comparison participantsAltered volumeFunctional alterationsMatter volumeUnmedicated individualsCerebellar involvementBrain regions
2016
Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers
Garrison KA, Sinha R, Lacadie CM, Scheinost D, Jastreboff AM, Constable RT, Potenza MN. Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers. Nicotine & Tobacco Research 2016, 18: 1820-1829. PMID: 26995796, PMCID: PMC4978981, DOI: 10.1093/ntr/ntw088.Peer-Reviewed Original ResearchConceptsFunctional connectivityBrain regionsSupramarginal gyrusFavorite-food cuesSmoking-related alterationsMagnetic resonance imaging studyBrain functional connectivity patternsPrevious functional magnetic resonance imaging (fMRI) studiesTobacco use disorderBrain networksIntrinsic connectivity distributionResonance imaging studyFunctional magnetic resonance imaging studyFunctional connectivity patternsMultiple brain networksSmoking cessationNonsmokersPosterior insulaRolandic operculumSmokersFunctional brain networksImaging studiesGreater connectivityNeural responsesRecent reports
2015
Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, Papademetris X, Constable RT. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nature Neuroscience 2015, 18: 1664-1671. PMID: 26457551, PMCID: PMC5008686, DOI: 10.1038/nn.4135.Peer-Reviewed Original Research
2014
Resting state functional connectivity predicts neurofeedback response
Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Resting state functional connectivity predicts neurofeedback response. Frontiers In Behavioral Neuroscience 2014, 8: 338. PMID: 25309375, PMCID: PMC4173810, DOI: 10.3389/fnbeh.2014.00338.Peer-Reviewed Original ResearchObsessive-compulsive disorderOrbitofrontal cortexFunctional connectivityNeurofeedback trainingState functional connectivityWhole-brain connectivityBrain functional connectivityResting-state fMRITarget brain regionsBrodmann area 10Clinical symptomatologyContamination anxietyProminent symptomAnterior prefrontal cortexBrain regionsNeuropsychiatric disordersRs-fMRIBehavioral improvementPrefrontal cortexSame protocolPilot dataBA 10Neurofeedback protocolReliable predictorCortexCoupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data
Scheinost D, Shen X, Finn E, Sinha R, Constable RT, Papademetris X. Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data. PLOS ONE 2014, 9: e93544. PMID: 24676034, PMCID: PMC3968179, DOI: 10.1371/journal.pone.0093544.Peer-Reviewed Original ResearchConceptsHealthy controlsIntrinsic connectivity distributionCocaine-dependent subjectsResting-state scansSeed-based analysisConnectivity analysisSimilar brain regionsBasic neuroscience researchMagnetic resonance imaging dataPsychiatric diseasesVoxel-based resultsConnectivity differencesBrain regionsClinical toolFunctional changesFunctional magnetic resonance imaging (fMRI) dataScansVoxel-based methodConnectivity approachNeuroscience researchConnectivity dataBOLD signal and functional connectivity associated with loving kindness meditation
Garrison KA, Scheinost D, Constable RT, Brewer JA. BOLD signal and functional connectivity associated with loving kindness meditation. Brain And Behavior 2014, 4: 337-347. PMID: 24944863, PMCID: PMC4055184, DOI: 10.1002/brb3.219.Peer-Reviewed Original ResearchConceptsPCC/PCuFunctional connectivityGreater functional connectivityIntrinsic connectivityPosterior cingulate cortex/precuneusParahippocampus/hippocampusSeed-based connectivity analysisBOLD signalBlood oxygen level-dependent (BOLD) signalGroup differencesIntrinsic connectivity distributionLevel-dependent signalKindness meditationCortical midline regionsDefault mode networkFunctional magnetic resonanceInsula lobeInferior frontal gyrusSilent repetitionBrain regionsLeft inferior frontal gyrusFrontal gyrusMidline regionSelf-related processingMode network
2013
A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes
Mitchell MR, Balodis IM, DeVito EE, Lacadie CM, Yeston J, Scheinost D, Constable RT, Carroll KM, Potenza MN. A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. The American Journal Of Drug And Alcohol Abuse 2013, 39: 392-402. PMID: 24200209, PMCID: PMC3827911, DOI: 10.3109/00952990.2013.841711.Peer-Reviewed Original ResearchConceptsTreatment outcomesComparison subjectsCocaine-dependent patientsIntrinsic connectivityCocaine dependenceSubstantia nigraVentral striatumTreatment-seeking cocaine-dependent patientsHealthy comparison subjectsPotential treatment targetGreater intrinsic connectivityRegional brain activationCocaine-dependent groupIntrinsic connectivity analysesNon-addicted individualsBasal gangliaInferior frontal gyrusCocaine-dependent individualsTreatment targetsFMRI Stroop taskSubcortical regionsCocaine abstinenceBrain regionsAnterior insulaFrontal gyrusOrbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
2012
Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety.
Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. Journal Of Visualized Experiments 2012 PMID: 22297729, PMCID: PMC3462579, DOI: 10.3791/3535.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOrbitofrontal cortexBrain areasContamination anxietySymptom severityQuarter of patientsSpecific brain areasClinical improvementControl subjectsClinical changesMagnetic resonance imaging dataHealthy subjectsPsychiatric disordersTherapeutic interventionsFunctional magnetic resonance imaging (fMRI) dataBrain regionsObsessive-compulsive symptomsBrain functionTraining subjectsOCD symptom severityBiofeedback interventionConsistent findingCortexBiofeedback trainingBiofeedback