2012
Anatomical Brain Images Alone Can Accurately Diagnose Chronic Neuropsychiatric Illnesses
Bansal R, Staib LH, Laine AF, Hao X, Xu D, Liu J, Weissman M, Peterson BS. Anatomical Brain Images Alone Can Accurately Diagnose Chronic Neuropsychiatric Illnesses. PLOS ONE 2012, 7: e50698. PMID: 23236384, PMCID: PMC3517530, DOI: 10.1371/journal.pone.0050698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlgorithmsAttention Deficit Disorder with HyperactivityBipolar DisorderBrainChildDepressive Disorder, MajorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSchizophreniaSensitivity and SpecificityTourette SyndromeConceptsBrains of personsNeuropsychiatric illnessBrain regionsNeuropsychiatric disordersMRI scansMajor depressive disorderChronic neuropsychiatric disorderAttention-deficit/hyperactivity disorderSpecific neuropsychiatric disordersDifferent neuropsychiatric disordersLarge MRI datasetsAnatomical MRI scansDisease courseCerebral cortexLow familial riskDepressive disorderBiological subtypesTourette syndromeBipolar disorderAnatomical brain imagesClinical diagnosisFamilial riskIllnessDiagnostic accuracyDiagnostic algorithm
2004
Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants