Nalan Yurtsever
Cards
About
Research
Publications
2025
Why auto‐anti‐D might be more likely than allo‐anti‐D for people with conventional D type
Yurtsever N, Liu J, Cedeno E, Tormey C, Denomme G, Horstman E. Why auto‐anti‐D might be more likely than allo‐anti‐D for people with conventional D type. British Journal Of Haematology 2025 DOI: 10.1111/bjh.70081.Peer-Reviewed Original ResearchEvaluating RhD assessment by automated methodology: A potential “blind spot” for RhD variant identification
Yurtsever N, Tormey C, Bizzario L, Lee E. Evaluating RhD assessment by automated methodology: A potential “blind spot” for RhD variant identification. Transfusion 2025, 65: 1574-1579. PMID: 40944507, DOI: 10.1111/trf.18343.Peer-Reviewed Original ResearchConceptsPositive predictive valueRHD genotypingD variantsWomen of Childbearing AgeRHD variant allelesHigh-risk patientsYale-New Haven HospitalAnti-D formationBlood bank protocolsTube testAnti-D AntibodiesNew Haven HospitalRh blood groupsChildbearing ageVariant allelesPatient populationTransfusion practicePatientsTraditional tube testsPredictive valueTransfusionBlood groupTransfusion servicesRHDSerological reactivity“Cryobit” aggregates in liquid plasma units
Gereg C, Tormey C, West F, Yurtsever N. “Cryobit” aggregates in liquid plasma units. Transfusion 2025, 65: 1383-1384. PMID: 40485613, DOI: 10.1111/trf.18308.Peer-Reviewed Original ResearchMedical, Societal, and Ethical Considerations for Directed Blood Donation in 2025.
Jacobs J, Booth G, Lewis-Newby M, Saifee N, Ferguson E, Cohn C, Delaney M, Morley S, Thomas S, Thorpe R, Raza S, Weaver M, Woo J, Sharma D, So-Osman C, Yurtsever N, Tormey C, Waters A, Goldman M, Yan M, Fasano R, Stephens L, Allen E, Erikstrup C, Infanti L, Schlafer T, Warner M, Winters J, Tobian A, Bloch E. Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025. Annals Of Internal Medicine 2025, 178: 1021-1026. PMID: 40354666, DOI: 10.7326/annals-25-00815.Peer-Reviewed Original ResearchDirected donationEthical principlesEthical concernsEthical considerationsLegislative attemptsPersonal beliefsLegislative effortsPublic trustMandate complianceDiscriminatory practicesScientific justificationDonation preferencesExacerbate shortagesScientific communityMedical necessityDonationPotential harmUnited StatesDirected blood donationsAllocation practicesEthicsLogistical burdenNon-evidence-based interventionsPatient safety risksBlood donationEvaluation of nonspecific reactivity rates across three immunohematology testing platforms with assessment of subsequent specific alloantibody development
Yurtsever N, Carmichael G, Malonis R, Madden M, Isik N, Ahmed M, Bizzario L, Shah B, Tormey C, Lee E. Evaluation of nonspecific reactivity rates across three immunohematology testing platforms with assessment of subsequent specific alloantibody development. Transfusion 2025, 65: 978-984. PMID: 40251842, PMCID: PMC12092180, DOI: 10.1111/trf.18256.Peer-Reviewed Original ResearchNonspecific reactivityAntibody screeningStrength of reactivityRate of positivityReagent red cellsAlloantibody developmentKruskal-Wallis testAntibody historyChart reviewPretransfusion testingAntibody identificationIRB approvalIdentification panelKruskal-WallisPositive screenAntibody detectionRed cellsAntibodiesAlloantibodiesStudy periodReactivation rateTube testNonspecific reactionsScreeningCellsMisoprostol administration mimicking a febrile transfusion reaction
Yurtsever N, Snyder E. Misoprostol administration mimicking a febrile transfusion reaction. Transfusion 2025, 65: 643-646. PMID: 39907501, DOI: 10.1111/trf.18150.Peer-Reviewed Original ResearchConceptsFebrile nonhemolytic transfusion reactionsTransfusion reactionsBlood culturesSynthetic prostaglandin E1 analogueThermogenic effectAdministration of misoprostolProstaglandin E1 analogueRed cell transfusionTransfusion medicineFebrile transfusion reactionsNonhemolytic transfusion reactionsG1P0 femaleMisoprostol administrationCell transfusionE1 analogueChart reviewSerological workupCase reportDifferential diagnosisEnhance patient satisfactionMisoprostolTransfusionUterotonic propertiesSerological findingsSide effects
2024
Prophylactic Red Cell Exchange: Preventing Complications in Pregnant Patients with Sickle Cell Disease
Sariipek N, Horstman E, Tormey C, Yurtsever N. Prophylactic Red Cell Exchange: Preventing Complications in Pregnant Patients with Sickle Cell Disease. Blood 2024, 144: 5340-5340. DOI: 10.1182/blood-2024-198650.Peer-Reviewed Original ResearchRed cell exchangeManagement of pregnancy-related complicationsSickle cell diseasePre-eclampsiaPregnancy-related complicationsCesarean sectionCell diseaseApgar scoreHealthy infantsPainful crisesBilateral retinal vein occlusionAmerican Society for Apheresis guidelinesSpectra Optia apheresis systemHematocrit levelsEmergency cesarean sectionRetinal artery occlusionRetinal vein occlusionBilateral renal infarctionSickle cell-related complicationsHistory of retinopathyPrevent pre-eclampsiaSecond-line therapyTransient vision lossWeeks of gestationPregnancy related complicationsAssessing the Effect of Changing the Average Hematocrit in Red Blood Cell (RBC) Units on the Post- Procedure Hematocrits of Patients Undergoing Erythrocytapheresis
Musante K, Roome L, Yurtsever N, Rinder H, Tormey C, Lee E. Assessing the Effect of Changing the Average Hematocrit in Red Blood Cell (RBC) Units on the Post- Procedure Hematocrits of Patients Undergoing Erythrocytapheresis. American Journal Of Clinical Pathology 2024, 162: s147-s147. DOI: 10.1093/ajcp/aqae129.326.Peer-Reviewed Original ResearchSickle cell diseaseRed blood cell unitsSickle cell disease patientsRed blood cellsPatient's HctRBC unitsTransfused RBC unitsRetrospective chart reviewTwo-sample t-testChart reviewAdverse eventsMedian numberPre-procedureProphylactic procedureCell diseasePatientsAcademic hospitalAverage hematocritAverage HctBlood cellsHctTransfusion servicesT-testQuality studiesHematocritHematocrits of red blood cell units increase during storage due to changes in mean corpuscular volume, impacting outcomes of red cell exchange procedures
Lee E, Musante K, Errico J, Rinder H, Kleinstein S, Tormey C, Yurtsever N. Hematocrits of red blood cell units increase during storage due to changes in mean corpuscular volume, impacting outcomes of red cell exchange procedures. American Journal Of Clinical Pathology 2024, 162: s157-s157. DOI: 10.1093/ajcp/aqae129.348.Peer-Reviewed Original ResearchMean corpuscular volumeMultilevel linear regression modelsPosterior meanStorage timeWeeks of storageRed blood cell exchangeFunction of storage timeLinear regression modelsRed blood cell unitsPosterior distribution of model parametersAkaike weightsMultilevel regression modelsRegression modelsRed blood cellsPosterior distributionDistribution of model parametersRBC unitsModel selectionRStan packageCorpuscular volumeHematological parametersFlow cytometry for RBC damage and complement activation
Villalba C, Yurtsever N, Paternoster K, Gallipoli P, Nash B, Bizzario L, Shah B, Rinder H, Tormey C, Lee E. Flow cytometry for RBC damage and complement activation. American Journal Of Clinical Pathology 2024, 162: s182-s183. DOI: 10.1093/ajcp/aqae129.400.Peer-Reviewed Original ResearchDirect antiglobulin testRed blood cellsTukey HSD testHSD testAntiglobulin testComplement depositionOne-way ANOVANegative direct antiglobulin testFlow cytometryRed blood cell clearanceStatistically significant differenceTwo-sample t-testPercentage of red blood cellsExposure of PSHealthy donorsDiluted red blood cellsRBC recoveryRBC unitsPhosphatidylserine expressionRBC injuryFlow cytometry assayHealthy individualsPS expressionRed blood cell ageComplement activation
Clinical Care
Overview
Nalan Yurtsever, MD, is a laboratory medicine specialist with expertise in transfusion support for both the general population and special patient groups, including individuals with sickle cell disease—an inherited blood disorder that leads to misshapen red blood cells and complications such as anemia and pain crises.
She also oversees apheresis services, providing red cell exchange, plasma exchange, and stem cell and CAR-T collections for patients, primarily those with hematologic and neurological diseases.
Dr. Yurtsever earned her medical degree from Ankara University School of Medicine in Turkey. She completed her anatomic and clinical pathology residency at the Zucker School of Medicine at Hofstra/Northwell and a transfusion medicine fellowship at Yale New Haven Hospital. She is board certified in anatomic and clinical pathology as well as transfusion medicine.
She currently serves as director of the Clinical Pathology Laboratory at Bridgeport Hospital’s Milford Campus, where she works to enhance the quality and accuracy of laboratory results. She is dedicated to improving diagnostic processes and ensuring that laboratory testing supports effective patient care.
Drawn to laboratory and transfusion medicine for its unique role in bridging direct patient care and diagnostic support, Dr. Yurtsever is committed to improving laboratory quality to enhance both diagnosis and treatment. Through her oversight of apheresis services, she provides direct supervision and care to patients undergoing specialized procedures.
As an assistant professor of laboratory medicine at Yale School of Medicine, Dr. Yurtsever conducts research focused on improving the management and treatment of patients requiring chronic transfusions. Her work aims to advance testing methods and deepen the understanding of transfusion-related challenges to improve patient outcomes. Her secondary research interests include leveraging laboratory databases to support long-term patient care, enable early diagnosis, and improve the prediction of health outcomes.
With a strong passion for research and innovation, Yale provides the ideal environment for Dr. Yurtsever to integrate clinical care, laboratory administration, translational research, and trainee mentorship.
Clinical Specialties
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Locations
Bridgeport Hospital
Lab
267 Grant Street, Wing Pathology, Fl 2nd floor
Bridgeport, CT 06610
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Everyone David Gibb, MD, PhD