2005
Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation
Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation. Anesthesia & Analgesia 2005, 101: 17-23. PMID: 15976199, DOI: 10.1213/01.ane.0000155260.93406.29.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationC-reactive proteinPreoperative C-reactive proteinCardiopulmonary bypassAtrial fibrillationCardiac surgerySinus rhythmAortic cross-clamp releaseTroponin IPilot studyCross-clamp releaseSubset of patientsCardiac muscle damageNormal sinus rhythmLeukocyte inflammatory responsesExploratory pilot studyPMN CD11bCPB patientsInflammatory infiltrationPMN countCD11b upregulationCellular inflammationInflammatory responseMonocyte activationMuscle damage
2003
Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Group M. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. The Annals Of Thoracic Surgery 2003, 75: 899-905. PMID: 12645714, DOI: 10.1016/s0003-4975(02)04490-9.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiopulmonary BypassCD11b AntigenCoronary Artery BypassCreatinineHeart FailureHeart Valve Prosthesis ImplantationHemodynamicsHumansIntra-Aortic Balloon PumpingLeukocyte CountMiddle AgedNeutrophilsPostoperative ComplicationsProspective StudiesRisk FactorsSystemic Inflammatory Response SyndromeConceptsAcute renal injuryNeutrophil CD11b upregulationRenal injuryCardiopulmonary bypassInflammatory responseCD11b upregulationAdult respiratory distress syndromeMarkers of leukocytesPlatelet CD62P expressionPostoperative hemodynamic supportPostoperative renal injuryNeutrophil inflammatory responseSystemic inflammatory responseRespiratory distress syndromeSubset of patientsC-reactive proteinTotal neutrophil countMonocyte CD11bRenal riskHemodynamic instabilityInflammatory markersPost-CPBHemodynamic supportMyeloperoxidase levelsNeutrophil count
2002
Platelet PlA2 Polymorphism and Platelet Activation Are Associated with Increased Troponin I Release after Cardiopulmonary Bypass
Rinder CS, Mathew JP, Rinder HM, Howe J, Fontes M, Crouch J, Pfau S, Patel P, Smith BR. Platelet PlA2 Polymorphism and Platelet Activation Are Associated with Increased Troponin I Release after Cardiopulmonary Bypass. Anesthesiology 2002, 97: 1118-1122. PMID: 12411794, DOI: 10.1097/00000542-200211000-00013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesCardiopulmonary BypassElectrocardiographyFemaleHumansIntegrin beta3MaleMiddle AgedPlatelet ActivationPolymorphism, GeneticPostoperative ComplicationsThrombosisTroponin IConceptsTroponin I concentrationsPlatelet glycoprotein IIIaCardiopulmonary bypassPlA2 polymorphismPlA2 alleleI concentrationsMyocardial injuryGlycoprotein IIIaPlatelet activationElective coronary artery bypassHigher troponin I concentrationsPostoperative troponin I concentrationsTroponin IPerioperative myocardial injuryCoronary artery bypassProthrombotic risk factorsCardiopulmonary bypass surgerySevere myocardial injuryArtery bypassBypass surgeryPlatelet polymorphismsRisk factorsCardiovascular settingsPlA2 genotypeBypass
2001
The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress
Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.Peer-Reviewed Original ResearchConceptsCollagen-induced thrombus formationPlatelet hemostasis timePartial thromboplastin timeAntiplatelet effectProthrombin timeAntithrombin effectPlatelet activationProtamine reversalPlatelet functionDirect antiplatelet effectCollagen-dependent platelet activationDirect thrombin inhibitorL-arginyl-chloromethyl ketoneClot Signature AnalyzerEffect of heparinCollagen-induced platelet activationEffect of protamineArterial shear stressBlood lossCardiopulmonary bypassPlatelet dysfunctionProtamine ratioPlatelet aggregometryAnticoagulant effectThromboplastin timePlatelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass
Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationPlA1/A1PlA1/A2Cardiopulmonary bypassNeurocognitive declinePlA2 polymorphismPlatelet GPIIIaState ExaminationBaseline Mini-Mental State ExaminationGreater neurocognitive declineProthrombotic genetic factorsPostoperative day 4Prothrombotic risk factorsEmbolic insultFrequent complicationPlA2 allelePlaque embolizationLocal thrombosisRisk factorsThrombotic processCardiovascular settingsPlA2 genotypeNeurocognitive changesDay 4Multivariate analysis
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashion
1986
HTLV-III infection after bone marrow transplantation.
Antin JH, Smith BR, Ewenstein BM, Arceci RJ, Lipton JM, Page PL, Rappeport JM. HTLV-III infection after bone marrow transplantation. Blood 1986, 67: 160-3. PMID: 3000475, DOI: 10.1182/blood.v67.1.160.bloodjournal671160.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultBone Marrow TransplantationDeltaretrovirusHumansMalePostoperative ComplicationsRetroviridae InfectionsT-LymphocytesTransfusion ReactionConceptsGraft-v-host diseaseHTLV-III infectionBone marrow transplantationHTLV-IIIMarrow transplantationChronic graft-v-host diseaseBone marrow transplant recipientsAcquisition of antibodiesChronic GVHD diseaseLate opportunistic infectionsLoss of immunocompetenceOnly risk factorMarrow transplant recipientsPeripheral blood lymphocytesTransfusion-associated AIDSGVHD diseaseLymphocyte phenotypingHost diseaseTransplant recipientsImmunodeficiency syndromeOpportunistic infectionsAsymptomatic individualsPatient's immunodeficiencyRisk factorsSevere immunodeficiency