Biomedical Engineering; Heart Valves; Miniaturization; Medical Laboratory Science; Heart Transplantation; Minimally Invasive Surgical Procedures; Heart Valve Prosthesis Implantation; Biomedical Technology
The major focus of my research is understanding the mechanisms and processes involved in myocardial recovery supported by mechanical circulatory support. The treatment of heart failure currently is targeted towards minimizing the neurohumoral effects (diuretics, ACE inhibitors, beta blockers) of failing myocardium and as such is merely symptomatic without improving the underlying heart failure. Mechanical circulatory support can reverse the heart failure and can be an effective strategy to interrupt the relentless progression of heart failure. My vision constitutes a small intra-cardiac mechanical circulatory device, which can be inserted by minimally invasive surgery and can be powered wirelessly to offer an un-tethered and unrestricted quality of life. Such device will use a novel controller algorithm to train the myocardium to recover to its fullest extent, eventually to be weaned completely from mechanical support. For such a vision to crystallize it needs three essential components: a small innovative ventricular assist device (VAD), a wireless transmission system and a reproducible animal model of heart failure. My lab has focused on these areas to bring this to reality in the last few years.
Extensive Research Description
FREE-D wireless power system
Artificial Lung(Pulmonary Assist device)
Myocardial recovery using LVAD as a bridge
Mechanical CPR devices
Percutaneous artificial heart valves
Instrumentation and devices for minimally invasive cardiac surgery
- Waters B, Sample A, Smith J, Bonde P. Toward total implantability using free-range resonant electrical energy delivery system: achieving untethered ventricular assist device operation over large distances. Cardiol Clin. 2011 Nov;29(4):609-25.
- Bonde P, Ku NC, Genovese EA, Bermudez CA, Bhama JK, Ciarleglio MM, Cong X, Teuteberg JJ, Kormos RL. Model for end-stage liver disease score predicts adverse events related to ventricular assist device therapy. Ann Thorac Surg. 2012 May;93(5):1541-7; discussion 1547-8.
- Benjamin H. Waters, Alanson P. Sample, Pramod Bonde, Joshua R. Smith, "Powering a Ventricular Assist Device (VAD) with the Free-Range Resonant Electrical Energy Delivery (FREE-D) System." Proceedings of the IEEE, vol.100, no.1, pp.138-149, January 2012.