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John Geibel, DSc, MD, AGAF, MS, FRS

Professor Emeritus of Surgery (Gastrointestinal)
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Additional Titles

Vice Chair, Surgery

Director, Surgical Research

American Gastroenterological Association Fellow

Fellow of the Royal Society of Medicine

About

Titles

Professor Emeritus of Surgery (Gastrointestinal)

Vice Chair, Surgery; Director, Surgical Research; American Gastroenterological Association Fellow; Fellow of the Royal Society of Medicine

Biography

John Geibel is Vice Chairman of the Department of Surgery at Yale School of Medicine and Director of Surgical Research and Professor of Cellular and Molecular Physiology. His early research training was in Innsbruck Austria where he worked in the Physiology Department and investigated renal physiology on the isolated perfused tubule model. He holds a Bachelors of Science Degree in Physiology, an MD and DSc degree as well as a Master’s of Science, and a Master’s of Arts Degree. He has also obtained his Dozent in Medicine from the University of Innsbruck. After obtaining his Dozent he went to Yale University first as a visiting fellow and then joined the faculty in both Surgery and Cellular and Molecular Physiology where he rose through the ranks to Professor in both faculties.

Academically, Professor Geibel’s active research interests are on the role of the Calcium Sensing Receptor (CaSR) in gastrointestinal physiology and pathophysiology. In addition, John Geibel has conducted research in fluid and electrolyte transport in the intestine where he was the first to identify that the colonic crypt can both actively secrete and absorb fluid. He has also identified 4 new transport pathways in the stomach that play important roles in acid secretion and may help to explain some of the hypersecretion of acid that occurs in patients. In addition he maintains a research program in the kidney where he was the first to identify a functional role for the H-ATPase in the proximal tubule; he was also the first to demonstrate a role for Angiotensin on the Na/H exchanger and Na/HCO3 and H-ATPase in the proximal tubule. Professor Geibel is the author of over 250 publications and presents his findings both nationally and internationally. He is the holder of 10 patents on the role of the calcium sensing receptor on gastrointestinal models and is currently actively working to begin clinical trials on a method to stop secretory diarrhea in the developing world based on targeting the calcium sensing receptor. He has also patented a new method to suppress acid secretion. Recently Dr. Geibel has actively developed a 3D Bioprinting program for vascular anomalies and intestinal repair.

Appointments

Education & Training

MD
University of Innsbruck (1986)
DSc
University of Innsbruck (1983)
MS
University of New Brunswick, Physiology (1981)

Research

Overview

We are focused on 3 main areas; gastric ion transport in health and disease, intestinal ion transport in health and disease, and 3DBioprinting. For gastric ion transport we are focusing on means to modulate acid secretion and reverse erosion. We use a combination of natural products and biochemical modifications to treat acid disease at the cellular level. For studies of intestinal ion transport, we are focusing on how the calcium sensing receptor(CaSR) can modulate fluid transport during toxin induced diarrhea. We are also looking at nanoparticle therapies for Ulcerative Colitis. In addition we are investigating means to prevent ischemic injury by activating ionic pathways using the AMPKinase. Finally we are trying to prevent IBD/IBS associated epithelial injury in the gut by CaSR activation using nutraceuticals . For the 3DBioprinting area we are developing replacement conduits that can be used for the aorta, the inferior vena cava, and also as small and large intestine repair tool. Along with this research we are now examining the potential for intestinal elongation using a 3D printed replacement.

Medical Subject Headings (MeSH)

Bioprinting; Chemicals and Drugs; Diarrhea; Electrophysiology; Gastric Acid; Gastroenterology; Gastrointestinal Agents; Physiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of John Geibel's published research.

Publications

2023

2022

2021

2020

Academic Achievements & Community Involvement

  • activity

    New Insights in 3D Bioprinting from Vessels to Intestines

  • honor

    America's Top Doctors

  • honor

    Doctor of Medicine h.c.

  • honor

    America's Top Doctors

  • activity

    eMedicine

Get In Touch

Contacts

Academic Office Number
Lab Number
Office Fax Number
Mailing Addresses

Gastrointestinal Surgery

PO Box 208062

New Haven, CT 06520-8062

United States

Yale University

BML 232, 310 Cedar Street

New Haven, CT 06510

United States

Administrative Support

Locations