Laura Manuelidis, MD

Professor of Surgery (Neuropathology); Section Chief Neuropathology (Surgery)

Departments & Organizations

Surgery: Neuropathology: Manuelidis Lab

Molecular Virology: Virology laboratories

Neural Disorders

Status of Women in Medicine Commitee (SWIM)

Office of Cooperative Research


Dr. Manuelidis studies neurodegenerative diseases, with an emphasis on infectious human Creutzfeldt-Jakob Disease and sheep scrapie, and has developed unique animal and culture models. These models have revealed fundamental routes of infection, innate immune responses to a foreign infectious agent, and structural characteristics of the infectious particle. Infectious particles can be stripped of detectable prion protein (PrP) yet remain highly infectious. Host PrP misfolding is a late stress response to trap and eliminate these infectious agents. Deep proteomic sequencing has also uncovered new neurodegenerative pathways for therapy and prevention.

Education & Training

MD Yale University (1967)
BA Sarah Lawrence College (1963)


  • Creutzfeldt-Jakob Disease Mad Cow Disease Alzheimer's Disease New Haven, United States (2008)

    Professor Manuelidis has collaborations with investigators abroad on "mad cow disease" and human Creutzfeldt-Jakob Disease. Recent collaborators include Dr. Kohtaro Miyazawa of Tohoku University in Sendai, Japan.

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Contact Info

Laura Manuelidis, MD
Mailing Address
Yale SurgeryPO Box 208062
New Haven, CT 06520-8062

Curriculum Vitae

CJD Agents & Disease

Infectious Particles

Lab Website (Home)

Major Chromosome Discoveries

Major CJD Discoveries