Departments & Organizations
Molecular Virology: Virology laboratories
Dr. Manuelidis studies neurodegenerative diseases, with an emphasis on infectious human Creutzfeldt-Jakob Disease and sheep scrapie, and has developed unique animal and culture models. These models have revealed fundamental routes of infection, innate immune responses to a foreign infectious agent, and structural characteristics of the infectious particle. Infectious particles can be stripped of detectable prion protein (PrP) yet remain highly infectious. Host PrP misfolding is a late stress response to trap and eliminate these infectious agents. Deep proteomic sequencing has also uncovered new neurodegenerative pathways for therapy and prevention.
Education & Training
|MD||Yale University (1967)|
|BA||Sarah Lawrence College (1963)|
Creutzfeldt-Jakob Disease Mad Cow Disease Alzheimer's Disease New Haven, United States (2008)
Professor Manuelidis has collaborations with investigators abroad on "mad cow disease" and human Creutzfeldt-Jakob Disease. Recent collaborators include Dr. Kohtaro Miyazawa of Tohoku University in Sendai, Japan.