Charles Christian Matouk, MD

Assistant Professor of Neurosurgery and of Diagnostic Radiology

Research Interests

Cerebrovascular Disorders; Diagnostic Techniques, Neurological; Endothelium, Vascular; Molecular Biology; Neurosurgery; Radiology

Research Organizations

Neurosurgery: Brain Aneurysm & AVM Program

Research Summary

My basic science research interests involve the molecular and genetic characterization of vascular diseases of the central nervous system (CNS). In particular, under the mentorship of Dr. Murat Gunel, we are currently using cutting edge molecular genetics to better understand cerebrovascular disease.

My translational research interests involve the application of advanced imaging protocols in the risk stratification of cerebrovascular disease. A current focus is the application of high-resolution magnetic resonance vessel wall imaging in the evaluation of patients with subarachnoid hemorrhage.

Specialized Terms: Molecular biology; Genetics of a diseased vascular endothelium in cerebrovascular disorders; Translational application of advanced imaging protocols in risk stratification of neurovascular disease

Selected Publications

  • Vessel wall magnetic resonance imaging identifies the site of rupture in patients with multiple intracranial aneurysms: proof of principle. Matouk C, Mandell DM, Gunel M, Bulsara KR, Malhotra A, Hebert R, Johnson MH, Mikulis DJ, Minja FJ. Vessel wall MRI identifies the site-of-rupture in patients with multiple intracranial aneurysms: proof-of-principle. Neurosurgery. 2013 Mar;72(3):492-6; discussion 496. doi: 10.1227/NEU.0b013e31827d1012.
  • Matouk C, Turgeon PJ, Marsden PA. Epigenetics and stroke risk - beyond the static DNA code. Adv Genomics Genet. 2012 Oct;2:67-84.
  • Matouk C, Kaderali Z, Terbrugge KG, Willinsky RA. Parent vessel occlusion for the treatment of complex aneurysms: long-term clinical and imaging follow-up. Am J Neuroradiol. 2012 Nov;33(10):1991-7.
  • Alkins R, Matouk C, Cruz JP, Marotta T, Montantera W, Spears J. Carotid artery angioplasty and stenting for patients less than 70 years of age: a longitudinal cohort study. Can J Neurol Sci. 2012 May;39(3):338-42.
  • Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. Mandell DM, Matouk C, Farb RI, Krings T, Agid R, Terbrugge K, Willinsky RA, Swartz RH, Silver FL, Mikulis DJ. Stroke. 2012 Mar;43(3):860-2. doi: 10.1161/STROKEAHA.111.626184. Epub 2011 Dec 8.
  • Martin AR, Pablo Cruz J, Matouk C, Spears J, Marotta TR. The Pipeline flow-diverting stent for exclusion of ruptured intracranial aneurysms with difficult morphologies. Neurosurgery. 2012 Mar;70(1 Suppl Operative):21-8.
  • Matouk C, Marsden PA. Epigenetic regulation of vascular endothelial gene expression. Circ Res. 2008 Apr 25;102(8):873-87.

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Contact Info

Charles Christian Matouk, MD
Patient Care Location
Yale Neurosciences InstituteYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
Mailing Address
PO Box 208082
New Haven, CT 06520-8082