Clinical and Neurologic Evaluation of the Mouse

Test

Normal Response

System tested

Body condition

No visible bony protruberences, no obesity

General health

Respiration

Barely visible

Cardiopulmonary, musculoskeletal, hematopoeitic systems

Eyelids

Wide open, clean, no excessive lacrimation

Ocular disease, central nervous system

Teeth and tongue

Teeth are aligned, tongue moves and is pink and smooth, no excessive salivation

Abnormalities can cause emaciation and death

Skin and coat

Pink mucosae, smooth skin and intact coat

Cardiopulmonary, hematologic and dermatologic systems

Body tone

Slight resistance when squeezed gently

General health, nervous, musculoskeletal, behavioural systems

Abdominal palpation

No masses, slight resistance

Intrabdominal disease, nervous, musculoskeletal, behavioural systems

Limb tone/grasping strength

Detectable tone, strong grasp on cage wire

Nervous, musculoskeletal, behavioural systems

Spontaneous activity

Grooming, moderate movement and exploration

General health, neuromuscular system, anxiety, fear

Observation of body position

Sitting or standing

General health, neuromuscular system

Tremors

None

Central nervous system

Circling/ataxia

None

Vestibular or cerebellar disease

Quadri/paraplegia/tail position/gait

Normal gait with horizontally extended tail

Central nervous system, musculoskeletal system

Seizures

No

Central nervous system

Stereotypies

No

Central nervous system, behavioural

Trunk and limb position when lifted by tail

Trunk curls, limbs splayed

Central nervous system, behavioural

Visual placing

Forearms extend to meet cage floor when mouse is lowered by tail

Visual system

Forelimb wheelbarrow

Forearms move normally when hind limbs elevated by tail.

Central nervous and musculoskeletal systems

Eye blink and ear twitch reflexes

Single eye blink, ear retraction

Cranial nerves V and VII

Toe pinch

Retraction

Central nervous and musculoskeletal systems

Righting reflex

Immediately rights when placed supine

Central nervous and musculoskeletal systems

Induced biting

Can be normal

Behavioural

Spontaneous biting

Abnormal

Behavioural

Vocalization when restrained

Can be normal

Behavioural