Clinical and Neurologic Evaluation of the Mouse

Test

 

Normal Response

 

System tested

Body condition

 

No visible bony protruberences, no obesity

 

General health

Respiration

 

Barely visible

 

Cardiopulmonary, musculoskeletal, hematopoeitic systems

Eyelids

 

Wide open, clean, no excessive lacrimation

 

Ocular disease, central nervous system

Teeth and tongue

 

Teeth are aligned, tongue moves and is pink and smooth, no excessive salivation

 

Abnormalities can cause emaciation and death

Skin and coat

 

Pink mucosae, smooth skin and intact coat

 

Cardiopulmonary, hematologic and dermatologic systems

Body tone

 

Slight resistance when squeezed gently

 

General health, nervous, musculoskeletal, behavioural systems

Abdominal palpation

 

No masses, slight resistance

 

Intrabdominal disease, nervous, musculoskeletal, behavioural systems

Limb tone/grasping strength

 

Detectable tone, strong grasp on cage wire

 

Nervous, musculoskeletal, behavioural systems

Spontaneous activity

 

Grooming, moderate movement and exploration

 

General health, neuromuscular system, anxiety, fear

Observation of body position

 

Sitting or standing

 

General health, neuromuscular system

Tremors

 

None

 

Central nervous system

Circling/ataxia

 

None

 

Vestibular or cerebellar disease

Quadri/paraplegia/tail position/gait

 

Normal gait with horizontally extended tail

 

Central nervous system, musculoskeletal system

Seizures

 

No

 

Central nervous system

Stereotypies

 

No

 

Central nervous system, behavioural

Trunk and limb position when lifted by tail

 

Trunk curls, limbs splayed

 

Central nervous system, behavioural

Visual placing

 

Forearms extend to meet cage floor when mouse is lowered by tail

 

Visual system

Forelimb wheelbarrow

 

Forearms move normally when hind limbs elevated by tail.

 

Central nervous and musculoskeletal systems

Eye blink and ear twitch reflexes

 

Single eye blink, ear retraction

 

Cranial nerves V and VII

Toe pinch

 

Retraction

 

Central nervous and musculoskeletal systems

Righting reflex

 

Immediately rights when placed supine

 

Central nervous and musculoskeletal systems

Induced biting

 

Can be normal

 

Behavioural

Spontaneous biting

 

Abnormal

 

Behavioural

Vocalization when restrained

 

Can be normal

 

Behavioural