Yang Yang
Research Associate NeurosurgeryCards
About
Research
Publications
2024
Constrained nuclear-electronic orbital QM/MM approach for simulating complex systems with quantum nuclear delocalization effects incorporated
Zhao X, Chen Z, Yang Y. Constrained nuclear-electronic orbital QM/MM approach for simulating complex systems with quantum nuclear delocalization effects incorporated. Chemical Physics Reviews 2024, 5: 041401. DOI: 10.1063/5.0226271.Peer-Reviewed Original ResearchNuclear quantum effectsDelocalization effectQM/MM approachLow barrier hydrogen bondHybrid quantum mechanics/molecular mechanicsHydrogen-bonded complexesHydrogen-bonded structureQuantum mechanics/molecular mechanicsElectrostatic embedding schemeProton sharingSolvation effectsQM/MM implementationQM methodsHydrogen bondsQM/MMQuantum effectsBonding structureNuclear-electronicBiological systemsMM methodComplex chemicalSimulating complex chemicalSolvationAccurate descriptionChemicalSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Yang Y, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie International Edition 2024, 63: e202412294. PMID: 39030890, DOI: 10.1002/anie.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Yang Y, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie 2024, 136 DOI: 10.1002/ange.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesCarrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors
Fang H, Zhang L, Wu Y, Chen L, Deng Z, Zheng Z, Wang Y, Yang Y, Chen Q. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chemical Engineering Journal 2024, 498: 155781. DOI: 10.1016/j.cej.2024.155781.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyImmunogenic cell deathDamage-associated molecular patternsPelvic tumorsIntraperitoneal chemotherapyGambogic acidAnti-tumor immune response in vivoInfiltration of cytotoxic T lymphocytesTriggering immunogenic cell deathRelease of damage-associated molecular patternsCancer cellsImmune responses in vivoCytotoxic T lymphocytesInduce apoptosis of cancer cellsApoptosis of cancer cellsResponses in vivoInhibitor of heat shock proteinCell deathHyperthermia-induced cell deathPenetration of nanoparticlesTumor extracellular matrixHeat shock proteinsOvarian cancerTumor microenvironmentT lymphocytesWhere is the hidden intramolecular H-bonding vibrational signal in the proline matrix IR spectrum?
Langford J, Zhang Y, Chen Z, Yang Y. Where is the hidden intramolecular H-bonding vibrational signal in the proline matrix IR spectrum? The Journal Of Chemical Physics 2024, 161: 134302. PMID: 39351935, DOI: 10.1063/5.0226184.Peer-Reviewed Original ResearchQuantifying network behavior in the rat prefrontal cortex
Sha C, Wang J, Mailman R, Yang Y, Dokholyan N. Quantifying network behavior in the rat prefrontal cortex. Frontiers In Computational Neuroscience 2024, 18: 1293279. PMID: 39268151, PMCID: PMC11390430, DOI: 10.3389/fncom.2024.1293279.Peer-Reviewed Original ResearchPrefrontal cortexT-maze alternation taskMedial prefrontal cortexWorking memory processesRat prefrontal cortexLocal field potential recordingsDynamic time warpingField potential recordingsAlternation taskT-mazeMemory processesPsychiatric disordersRat behaviorLocal field potentialsPrimate literatureNeural activitySpike trainsInsufficient statistical powerTime warpingNeural network synchronizationCortexElectrophysiological activityPotential recordingsNeuronal spike trainsField potentialsA Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy
Miao Y, Niu L, Lv X, Zhang Q, Xiao Z, Ji Z, Chen L, Liu Y, Liu N, Zhu J, Yang Y, Chen Q. A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy. Advanced Materials 2024, 36: e2410715. PMID: 39210649, DOI: 10.1002/adma.202410715.Peer-Reviewed Original ResearchCancer immunotherapyMaturation of antigen-presenting cellsVaccine carriersImmune checkpoint blockade therapyAntigen-specific immune responsesInhibition of tumor growthCheckpoint blockade therapyEnhanced cancer immunotherapyAntigen-presenting cellsVaccine delivery technologiesB16-OVABlockade therapyImmune activationTumor modelTumor growthAntigen loadNanovaccineImmune responseMeticulous screeningAntigenic peptidesImmunostimulatory characteristicsChain ratioDelivery technologiesImmunotherapyIn vivoExpression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma
Xu X, Jin K, Xu X, Yang Y, Zhou B. Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma. The Journal Of Gene Medicine 2024, 26: e3735. PMID: 39171952, DOI: 10.1002/jgm.3735.Peer-Reviewed Original ResearchConceptsCell cycle-associated genesLung squamous carcinomaCell cycleMRNA expression dataGene expression profilesAssociated with positive prognosisCause of cancer-related deathExpression dataCancer Genome AtlasExpressed genesSquamous cell carcinomaLung squamous cell carcinomaTargeted therapy trialsGroup of patientsCancer-related deathsExpression of CDK4GenesExpression trendsExpression profilesMolecular studiesGenome AtlasSquamous carcinomaCell carcinomaPathological stagePrognostic valueAn Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing
Huang Y, Lu W, Yang Y. An Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing. 2024, 4201-4209. DOI: 10.24963/ijcai.2024/464.Peer-Reviewed Original ResearchGraph neural networksOver-smoothingNeural networkIssue of over-smoothingIntra-class edgesEmbeddings of nodesGroup of nodesGNNs’ performanceNode representationsSupervision signalsClass labelsPreserving smoothingInter-classEfficient clusteringEdge pruningGraph structureDiverse graphsClustering approachTopology augmentationGraphNodesEnhanced accuracyNetworkAccuracyScalabilityModulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification
Huang K, Yang Q, Bao M, Wang S, Zhao L, Shi Q, Yang Y. Modulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification. Journal Of The American Chemical Society 2024, 146: 21442-21452. PMID: 39038211, DOI: 10.1021/jacs.4c04106.Peer-Reviewed Original Research