Titus Boggon PhD

Associate Professor of Pharmacology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology

Signal Transduction

Structural Biology


Signal Transduction

Research Interests

Structural biology of signal transduction  more...


  • BS, University of Manchester, UK, 1995
  • Ph.D., University of Manchester, UK, 1998

Selected Publications

  • Li X, Ji W, Zhang R, Folta-Stogniew E, Min W, Boggon TJ. Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting-homology domain of cerebral cavernous malformation 3 (CCM3). Journal of Biological Chemistry. 2011; 286(29):26138-26147
  • Li X*, Zhang R*, Zhang H, He Y, Ji W, Min W‡, Boggon TJ‡. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. Journal of Biological Chemistry. 2010; 285(31):24099-24107.
  • Petri ET, Celic AS, Kennedy SD, Ehrlich BE, Boggon TJ‡, Hodsdon ME‡. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+ -dependent regulation of polcystin-2 channel activity. PNAS. 2010; 107(20):9176-81



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