Research

Overview

Positron Emission Tomography (PET) enables investigators to measure a wide range of in vivo physiology in human beings and laboratory animals with a non-invasive research tool. PET imaging research at Yale focuses on the development and applications of new tracer kinetic modeling methods and algorithms for PET image reconstruction and image quantification. PET radiochemistry research concentrates primarily on the development of new, short half-lived radiopharmaceuticals and applying them towards the investigation of biochemical transformations and drug mechanisms in primates and humans.

Current Projects

PET ImagingPET Imaging 

PET Imaging Research

Our research uses Positron Emission Tomography (PET) as a tool to measure a wide range of in vivo physiology in human beings and laboratory animals in a non-invasive manner. We focus on the development and applications of new tracer kinetic modeling methods and algorithms and on research in PET image reconstruction and image quantification. A primary focus of our more biological applications is the measurement of dynamic changes in neurotransmitters. Read more...

PET RadiochemistryPET Radiochemistry 

PET Radiochemistry

Our research concentrates primarily on the development of new methodologies to synthesize short half-lived radiopharmaceuticals and applying them towards investigation of biochemical transformations and drug mechanisms in primates and humans. We have focused on the investigation of the functional significance of various neurotransmitter systems, such as dopamine, norepinephrine, serotonin, acetylcholine, as well as oncology and cardiology studies. Read more...