PET Group Publications

Naganawa M, Jacobsen LK, Zheng MQ, Lin SF, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Nabulsi N, Grimwood S, Badura LL, Carson RE, McCarthy TJ and Huang Y: Evaluation of the agonist PET radioligand [(11)C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242. Neuroimage. 2014 Oct;99 :69-79. Epub 2014 May 17. PMID: 24844744


Esterlis I, Ranganathan M, Bois F, Pittman B, Picciotto MR, Shearer L, Anticevic A, Carlson J, Niciu MJ, Cosgrove KP and D'Souza DC: In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia. Biol Psychiatry. 2014 Sep 15;76 (6) :495-502. Epub 2013 Nov 13. PMID: 24360979


Kim SJ, Sullivan JM, Wang S, Cosgrove KP and Morris ED: Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner. Hum Brain Mapp. 2014 Sep;35 (9) :4876-91. Epub 2014 Apr 3. PMID: 24700424


Gallezot JD, Esterlis I, Bois F, Zheng MQ, Lin SF, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE and Cosgrove KP: Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand <sup>18</sup> F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse. 2014 Jul 17; Epub 2014 Jul 17. PMID: 25043426


Carpenter TO, Olear EA, Zhang JH, Ellis BK, Simpson CA, Cheng D, Gundberg CM and Insogna KL: Effect of Paricalcitol on Circulating Parathyroid Hormone in X-linked Hypophosphatemia: A Randomized, Double-blind, Placebo-controlled Study. J Clin Endocrinol Metab. 2014 Jul 16; :jc20142017. Epub 2014 Jul 16. PMID: 25029424


DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE and Esterlis I: In Vivo Ketamine-Induced Changes in [<sup>11</sup>C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5. Biol Psychiatry. 2014 Jul 10; Epub 2014 Jul 10. PMID: 25156701


Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE and Lee LV: Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. J Nucl Med. 2014 Jul 3; Epub 2014 Jul 3. PMID: 24994931


Castner SA, Murthy NV, Ridler K, Herdon H, Roberts BM, Weinzimmer DP, Huang Y, Zheng MQ, Rabiner EA, Gunn RN, Carson RE, Williams GV and Laruelle M: Relationship Between Glycine Transporter 1 Inhibition as Measured with Positron Emission Tomography and Changes in Cognitive Performances in Nonhuman Primates. Neuropsychopharmacology. 2014 Jul 3; Epub 2014 Jul 3. PMID: 24487737


Matuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT and Ding YS: Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO. Drug Alcohol Depend. 2014 Jun 1;139 :100-5. Epub 2014 Mar 20. PMID: 24717909


Zheng MQ, Kim SJ, Holden D, Lin SF, Need A, Rash K, Barth V, Mitch C, Navarro A, Kapinos M, Maloney K, Ropchan J, Carson RE and Huang Y: An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of 11C-LY2459989. J Nucl Med. 2014 May 22;55 (7) :1185-1191. Epub 2014 May 22. PMID: 24854795


Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE and Neumeister A: Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors. Neuropsychopharmacology. 2014 May 12; Epub 2014 May 12. PMID: 24820537


Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL and Hyder F: Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by (19)F chemical shift imaging. Magn Reson Imaging. 2014 May;32 (4) :305-13. Epub 2013 Dec 14. PMID: 24581725


Gallezot JD, Zheng MQ, Lim K, Lin SF, Labaree D, Matuskey D, Huang Y, Ding YS, Carson RE and Malison RT: Parametric Imaging and Test-Retest Variability of 11C-(+)-PHNO Binding to D2/D3 Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner. J Nucl Med. 2014 Apr 14;55 (6) :960-966. Epub 2014 Apr 14. PMID: 24732151


Gallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED and Cosgrove KP: Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET. Neuropsychopharmacology. 2014 Mar;39 (4) :866-74. Epub 2013 Oct 15. PMID: 24220025


Morris ED, Lucas MV, Petrulli JR and Cosgrove KP: How to design PET experiments to study neurochemistry: application to alcoholism. Yale J Biol Med. 2014 Mar;87 (1) :33-54. Epub 2014 Mar 5. PMID: 24600335


Jin X, Mulnix T, Sandiego CM and Carson RE: Evaluation of frame-based and event-by-event motion-correction methods for awake monkey brain PET imaging. J Nucl Med. 2014 Feb;55 (2) :287-93. Epub 2014 Jan 16. PMID: 24434295


Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE and Neumeister A: Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine. Neuroimage. 2014 Feb 1;86 :306-10. Epub 2013 Oct 10. PMID: 24121204


Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE and Huang Y: Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry. 2014 Jan 15;75 (2) :165-71. Epub 2013 Sep 12. PMID: 24035345


Castellan Baldan L, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW and Pittenger C: Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 2014 Jan 8;81 (1) :77-90. PMID: 24411733


Li S and Huang Y: In vivo imaging of the metabotropic glutamate receptor 1 (mGluR1) with positron emission tomography: recent advance and perspective. Curr Med Chem. 2014;21 (1) :113-23. PMID: 23992339


Liu J, Gao J, Tu S, Xu S, Liu Y, Shang W, Gu C, Huang Y and Han M: Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System. Evid Based Complement Alternat Med. 2014;2014 :542383. Epub 2014 Apr 2. PMID: 24799940

Naganawa M, Nabulsi N, Planeta B, Gallezot JD, Lin SF, Najafzadeh S, Williams W, Ropchan J, Labaree D, Neumeister A, Huang Y and Carson RE: Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter. J Cereb Blood Flow Metab. 2013 Dec;33 (12) :1886-96. Epub 2013 Aug 7. PMID: 23921898


Petrulli JR, Sullivan JM, Zheng MQ, Bennett DC, Charest J, Huang Y, Morris ED and Contessa JN: Quantitative analysis of [11C]-erlotinib PET demonstrates specific binding for activating mutations of the EGFR kinase domain. Neoplasia. 2013 Dec;15 (12) :1347-53. PMID: 24403856


Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE and Malison RT: Reductions in Brain 5-HT<sub>1B</sub> Receptor Availability in Primarily Cocaine-Dependent Humans. Biol Psychiatry. 2013 Nov 28; Epub 2013 Nov 28. PMID: 24433854


Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR and Esterlis I: Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography. Biol Psychiatry. 2013 Nov 15;74 (10) :768-76. Epub 2013 Jun 14. PMID: 23773793


Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA and Carson RE: Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals. J Nucl Med. 2013 Nov;54 (11) :1962-8. Epub 2013 Oct 10. PMID: 24115528


Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE and Neumeister A: Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. JAMA Psychiatry. 2013 Nov;70 (11) :1199-205. PMID: 24048210


Chan C, Jin X, Fung EK, Naganawa M, Mulnix T, Carson RE and Liu C: Event-by-event respiratory motion correction for PET with 3D internal-1D external motion correlation. Med Phys. 2013 Nov;40 (11) :112507. PMID: 24320466


Hannestad J, DellaGioia N, Gallezot JD, Lim K, Nabulsi N, Esterlis I, Pittman B, Lee JY, O'Connor KC, Pelletier D and Carson RE: The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain Behav Immun. 2013 Oct;33 :131-8. Epub 2013 Jul 9. PMID: 23850810


Jin X, Mulnix T, Gallezot JD and Carson RE: Evaluation of motion correction methods in human brain PET imaging--a simulation study based on human motion data. Med Phys. 2013 Oct;40 (10) :102503. PMID: 24089924


Sirianni RW, Zheng MQ, Saltzman WM, Huang Y and Carson RE: Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography. Mol Imaging Biol. 2013 Oct;15 (5) :596-605. PMID: 23624949


Kim SJ, Zheng MQ, Nabulsi N, Labaree D, Ropchan J, Najafzadeh S, Carson RE, Huang Y and Morris ED: Determination of the in vivo selectivity of a new κ-opioid receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey. J Nucl Med. 2013 Sep;54 (9) :1668-74. Epub 2013 Aug 5. PMID: 23918735


Jin X, Chan C, Mulnix T, Panin V, Casey ME, Liu C and Carson RE: List-mode reconstruction for the Biograph mCT with physics modeling and event-by-event motion correction. Phys Med Biol. 2013 Aug 21;58 (16) :5567-91. Epub 2013 Jul 29. PMID: 23892635


Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC and Cosgrove KP: Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking. J Vis Exp. 2013 Aug 6; (78) Epub 2013 Aug 6. PMID: 23963311


Doddamane I, Butler R, Jhaveri A, Chung GG and Cheng D: Where does radioimmunotherapy fit in the management of breast cancer? Immunotherapy. 2013 Aug;5 (8) :895-904. PMID: 23902558


Sandiego CM, Nabulsi N, Lin SF, Labaree D, Najafzadeh S, Huang Y, Cosgrove K and Carson RE: Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys. Synapse. 2013 Aug;67 (8) :489-501. Epub 2013 Mar 27. PMID: 23424090


Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ Jr, Piepmeier JM and Saltzman WM: Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A. 2013 Jul 16;110 (29) :11751-6. Epub 2013 Jul 1. PMID: 23818631


Sullivan JM, Kim SJ, Cosgrove KP and Morris ED: Limitations of SRTM, Logan graphical method, and equilibrium analysis for measuring transient dopamine release with [(11)C]raclopride PET. Am J Nucl Med Mol Imaging. 2013;3 (3) :247-60. Epub 2013 Apr 9. PMID: 23638336


Esterlis I, Hannestad JO, Perkins E, Bois F, D'Souza DC, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP and O'Malley SS: Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. Am J Psychiatry. 2013 Apr 1;170 (4) :399-407. PMID: 23429725


Sullivan JM, Lim K, Labaree D, Lin SF, McCarthy TJ, Seibyl JP, Tamagnan G, Huang Y, Carson RE, Ding YS and Morris ED: Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans. J Cereb Blood Flow Metab. 2013 Apr;33 (4) :532-41. Epub 2012 Dec 19. PMID: 23250105


Tomasi G, Nabulsi N, Zheng MQ, Weinzimmer D, Ropchan J, Blumberg L, Brown-Proctor C, Ding YS, Carson RE and Huang Y: Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates. J Nucl Med. 2013 Apr;54 (4) :600-8. Epub 2013 Feb 19. PMID: 23424192


Fung EK and Carson RE: Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines. Phys Med Biol. 2013 Mar 21;58 (6) :1903-23. Epub 2013 Feb 27. PMID: 23442733


Esterlis I, McKee SA, Kirk K, Lee D, Bois F, Stiklus SM, Seibyl JP, Krishnan-Sarin S, O'Malley SS, Staley JK and Cosgrove KP: Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving. Addict Biol. 2013 Mar;18 (2) :370-8. Epub 2012 Feb 21. PMID: 22353491


Zheng MQ, Nabulsi N, Kim SJ, Tomasi G, Lin SF, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Morris ED, Carson RE and Huang Y: Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging. J Nucl Med. 2013 Mar;54 (3) :455-63. Epub 2013 Jan 25. PMID: 23353688


Lee DE, Gallezot JD, Zheng MQ, Lim K, Ding YS, Huang Y, Carson RE, Morris ED and Cosgrove KP: Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm. Mol Imaging. 2013 Mar-Apr;12 (2) :77-82. PMID: 23415395


Potenza MN, Walderhaug E, Henry S, Gallezot JD, Planeta-Wilson B, Ropchan J and Neumeister A: Serotonin 1B receptor imaging in pathological gambling. World J Biol Psychiatry. 2013 Mar;14 (2) :139-45. Epub 2011 Sep 22. PMID: 21936763


Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE and Cosgrove KP: Imaging changes in synaptic acetylcholine availability in living human subjects. J Nucl Med. 2013 Jan;54 (1) :78-82. Epub 2012 Nov 15. PMID: 23160789


Sandiego CM, Weinzimmer D and Carson RE: Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM). Neuroimage. 2013 Jan 1;64 :571-81. Epub 2012 Aug 25. PMID: 22926293

Sherwin R, Slayman C, Rockwell S, Herold K, Williams K, Carson R, Mane S, Seow H, Max J and Johnson T: Yale Center for Clinical Investigation: leveraging industry partnerships and research cores. Clin Transl Sci. 2012 Dec;5 (6) :435-6. PMID: 23253663


Yan J, Planeta-Wilson B and Carson RE: Direct 4-D PET list mode parametric reconstruction with a novel EM algorithm. IEEE Trans Med Imaging. 2012 Dec;31 (12) :2213-23. Epub 2012 Aug 23. PMID: 22929383


Huang Y, Narendran R, Bischoff F, Guo N, Bae SA, Hwang DR, Lesage AS and Laruelle M: Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor. Synapse. 2012 Dec;66 (12) :1002-14. Epub 2012 Sep 29. PMID: 22927303


Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS and Cosgrove KP: Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. Neuroimage. 2012 Oct 15;63 (1) :232-9. Epub 2012 Jul 6. PMID: 22776451


Lin SF, Fan X, Yeckel CW, Weinzimmer D, Mulnix T, Gallezot JD, Carson RE, Sherwin RS and Ding YS: Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging. Nucl Med Biol. 2012 Oct;39 (7) :1081-6. Epub 2012 May 16. PMID: 22595487


Matuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE and Neumeister A: Age effects on serotonin receptor 1B as assessed by PET. J Nucl Med. 2012 Sep;53 (9) :1411-4. Epub 2012 Jul 31. PMID: 22851636


Saricicek A, Esterlis I, Maloney KH, Mineur YS, Ruf BM, Muralidharan A, Chen JI, Cosgrove KP, Kerestes R, Ghose S, Tamminga CA, Pittman B, Bois F, Tamagnan G, Seibyl J, Picciotto MR, Staley JK and Bhagwagar Z: Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder. Am J Psychiatry. 2012 Aug 1;169 (8) :851-9. PMID: 22772158


Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL and Cline GW: In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J Nucl Med. 2012 Jun;53 (6) :908-16. Epub 2012 May 9. PMID: 22573821


Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE and Rabiner EA: Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo. Synapse. 2012 Jun;66 (6) :489-500. Epub 2012 Feb 24. PMID: 22213512


Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR and O'Malley SS: Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Arch Gen Psychiatry. 2012 Apr;69 (4) :418-27. PMID: 22474108


Hannestad J, Subramanyam K, Dellagioia N, Planeta-Wilson B, Weinzimmer D, Pittman B and Carson RE: Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans. J Nucl Med. 2012 Apr;53 (4) :601-7. Epub 2012 Mar 13. PMID: 22414635


D'Souza DC, Esterlis I, Carbuto M, Krasenics M, Seibyl J, Bois F, Pittman B, Ranganathan M, Cosgrove K and Staley J: Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia. Am J Psychiatry. 2012 Mar;169 (3) :326-34. PMID: 22193533


Chen MK, Yasrebi M, Samii J, Staib LH, Doddamane I and Cheng DW: The utility of I-123 pretherapy scan in I-131 radioiodine therapy for thyroid cancer. Thyroid. 2012 Mar;22 (3) :304-9. Epub 2012 Feb 2. PMID: 22300251


Wang Y, Lim K, Normandin M, Zhao X, Cline GW and Ding YS: Synthesis and evaluation of [18F]exendin (9-39) as a potential biomarker to measure pancreatic β-cell mass. Nucl Med Biol. 2012 Feb;39 (2) :167-76. Epub 2011 Oct 26. PMID: 22033026

Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB and Strittmatter SM: Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov;70 (5) :805-21. PMID: 22162062


Ersahin D, Doddamane I and Cheng D: Targeted radionuclide therapy. Cancers (Basel). 2011 Oct 11;3 (4) :3838-55. Epub 2011 Oct 11. PMID: 24213114


Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL and Cline GW: Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol. 2011 Oct;13 (5) :973-84. Epub 2010 Sep 8. PMID: 20824509


Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin SF, Staley JK, Bhagwagar Z and Carson RE: Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release. Synapse. 2011 Oct;65 (10) :1113-7. Epub 2011 May 3. PMID: 21484884


Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H and Gelernter J: Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry. 2011 Sep 15;70 (6) :528-36. Epub 2011 Jun 17. PMID: 21683344


Yang Q, Karpikov A, Toomre D and Duncan JS: 3-D reconstruction of microtubules from multi-angle total internal reflection fluorescence microscopy using Bayesian framework. IEEE Trans Image Process. 2011 Aug;20 (8) :2248-59. Epub 2011 Feb 14. PMID: 21324778


Cosgrove KP, Esterlis I, Mason GF, Bois F, O'Malley SS and Krystal JH: Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology. 2011 Jun;60 (7-8) :1318-25. Epub 2011 Jan 27. PMID: 21276806


Xu Y, Rubin BR, Orme CM, Karpikov A, Yu C, Bogan JS and Toomre DK: Dual-mode of insulin action controls GLUT4 vesicle exocytosis. J Cell Biol. 2011 May 16;193 (4) :643-53. Epub 2011 May 9. PMID: 21555461


Liu C, Alessio AM and Kinahan PE: Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation. Med Phys. 2011 May;38 (5) :2715-23. PMID: 21776808


Gallezot JD, Weinzimmer D, Nabulsi N, Lin SF, Fowles K, Sandiego C, McCarthy TJ, Maguire RP, Carson RE and Ding YS: Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates. Neuroimage. 2011 May 1;56 (1) :268-79. Epub 2010 Sep 30. PMID: 20869448


Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK and Cosgrove KP: Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. Int J Neuropsychopharmacol. 2011 Apr;14 (3) :389-98. Epub 2010 Oct 29. PMID: 21029513


Karpikov A, Rozowsky J and Gerstein M: Tiling array data analysis: a multiscale approach using wavelets. BMC Bioinformatics. 2011 Feb 21;12 :57. Epub 2011 Feb 21. PMID: 21338513


Vanstone MB, Udelsman RD, Cheng DW and Carpenter TO: Rapid correction of bone mass after parathyroidectomy in an adolescent with primary hyperparathyroidism. J Clin Endocrinol Metab. 2011 Feb;96 (2) :E347-50. Epub 2010 Nov 24. PMID: 21106715


Nabulsi NB, Zheng MQ, Ropchan J, Labaree D, Ding YS, Blumberg L and Huang Y: [11C]GR103545: novel one-pot radiosynthesis with high specific activity. Nucl Med Biol. 2011 Feb;38 (2) :215-21. Epub 2010 Dec 3. PMID: 21315277

Cosgrove KP, Tellez-Jacques K, Pittman B, Petrakis I, Baldwin RM, Tamagnan G, Seibyl J, Kosten T and Staley JK: Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study. Psychiatry Res. 2010 Dec 30;184 (3) :192-5. Epub 2010 Nov 3. PMID: 21050726


Hannestad J, Gallezot JD, Planeta-Wilson B, Lin SF, Williams WA, van Dyck CH, Malison RT, Carson RE and Ding YS: Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biol Psychiatry. 2010 Nov 1;68 (9) :854-60. Epub 2010 Aug 5. PMID: 20691429


Liu C, Alessio A, Pierce L, Thielemans K, Wollenweber S, Ganin A and Kinahan P: Quiescent period respiratory gating for PET/CT. Med Phys. 2010 Sep;37 (9) :5037-43. PMID: 20964223


Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH and Staley JK: Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates. Synapse. 2010 Sep;64 (9) :729-32. PMID: 20340174


Esterlis I, Cosgrove KP, Batis JC, Bois F, Stiklus SM, Perkins E, Seibyl JP, Carson RE and Staley JK: Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding. J Nucl Med. 2010 Aug;51 (8) :1226-33. Epub 2010 Jul 21. PMID: 20660383


Cosgrove KP, Staley JK, Baldwin RM, Bois F, Plisson C, Al-Tikriti MS, Seibyl JP, Goodman MM and Tamagnan GD: SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain. Nucl Med Biol. 2010 Jul;37 (5) :587-91. Epub 2010 May 6. PMID: 20610163


Cosgrove KP, Esterlis I, McKee S, Bois F, Alagille D, Tamagnan GD, Seibyl JP, Krishnan-Sarin S and Staley JK: Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. Nicotine Tob Res. 2010 May;12 (5) :535-9. Epub 2010 Apr 6. PMID: 20371741


Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH and Staley JK: SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug Alcohol Depend. 2010 Apr 1;108 (1-2) :146-50. Epub 2010 Jan 13. PMID: 20074869


Detterbeck F, Puchalski J, Rubinowitz A and Cheng D: Classification of the thoroughness of mediastinal staging of lung cancer. Chest. 2010 Feb;137 (2) :436-42. PMID: 20133290


Qiu M, Paul Maguire R, Arora J, Planeta-Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Rajeevan N, Huang Y, Carson RE and Constable RT: Arterial transit time effects in pulsed arterial spin labeling CBF mapping: insight from a PET and MR study in normal human subjects. Magn Reson Med. 2010 Feb;63 (2) :374-84. PMID: 19953506


Nabulsi N, Huang Y, Weinzimmer D, Ropchan J, Frost JJ, McCarthy T, Carson RE and Ding YS: High-resolution imaging of brain 5-HT 1B receptors in the rhesus monkey using [11C]P943. Nucl Med Biol. 2010 Feb;37 (2) :205-14. Epub 2009 Dec 1. PMID: 20152720


Chen MK, Doddamane I and Cheng DW: Recombinant human thyroid-stimulating hormone as an alternative for thyroid hormone withdrawal in thyroid cancer management. Curr Opin Oncol. 2010 Jan;22 (1) :6-10. PMID: 19844179


Cosgrove KP: Imaging receptor changes in human drug abusers. Curr Top Behav Neurosci. 2010;3 :199-217. PMID: 21161754


Huang Y, Zheng MQ and Gerdes JM: Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination? Curr Top Med Chem. 2010;10 (15) :1499-526. PMID: 20583995


Gallezot JD, Nabulsi N, Neumeister A, Planeta-Wilson B, Williams WA, Singhal T, Kim S, Maguire RP, McCarthy T, Frost JJ, Huang Y, Ding YS and Carson RE: Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans. J Cereb Blood Flow Metab. 2010 Jan;30 (1) :196-210. Epub 2009 Sep 23. PMID: 19773803


Yang Q, Karpikov A, Toomre D and Duncan J: Estimation of 3D geometry of microtubules using multi-angle total internal reflection fluorescence microscopy. Med Image Comput Comput Assist Interv. 2010;13 (Pt 2) :538-45. PMID: 20879357


Ding YS, Singhal T, Planeta-Wilson B, Gallezot JD, Nabulsi N, Labaree D, Ropchan J, Henry S, Williams W, Carson RE, Neumeister A and Malison RT: PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT. Synapse. 2010 Jan;64 (1) :30-8. PMID: 19728366

Sboner A, Karpikov A, Chen G, Smith M, Mattoon D, Freeman-Cook L, Schweitzer B and Gerstein MB: Robust-linear-model normalization to reduce technical variability in functional protein microarrays. J Proteome Res. 2009 Dec;8 (12) :5451-64. PMID: 19817483


Esterlis I, Cosgrove KP, Batis JC, Bois F, Kloczynski TA, Stiklus SM, Perry E, Tamagnan GD, Seibyl JP, Makuch R, Krishnan-Sarin S, O'Malley S and Staley JK: GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression. Synapse. 2009 Dec;63 (12) :1089-99. PMID: 19642218


Yan J, Planeta-Wilson B, Gallezot JD and Carson RE: Initial Evaluation of Direct 4D Parametric Reconstruction with Human PET Data. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Nov 1;2009 (Oct. 24 2009-Nov. 1 2009) :2503-2506. PMID: 21278923


Jin X, Mulnix T, Planeta-Wilson B, Gallezot JD and Carson RE: Accuracy of Head Motion Compensation for the HRRT: Comparison of Methods. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24;2009 :3199-3202. PMID: 20607125


Fung EK, Planeta-Wilson B, Mulnix T and Carson RE: A Multimodal Approach to Image-Derived Input Functions for Brain PET. IEEE Nucl Sci Symp Conf Rec (1997). 2009 Oct 24;2009 :2710-2714. PMID: 20607124


Mitsis EM, Reech KM, Bois F, Tamagnan GD, Macavoy MG, Seibyl JP, Staley JK and van Dyck CH: 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment. J Nucl Med. 2009 Sep;50 (9) :1455-63. Epub 2009 Aug 18. PMID: 19690024


Mitsis EM, Cosgrove KP, Staley JK, Bois F, Frohlich EB, Tamagnan GD, Estok KM, Seibyl JP and van Dyck CH: Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT. Neurobiol Aging. 2009 Sep;30 (9) :1490-7. Epub 2008 Feb 1. PMID: 18242781


Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS and Staley JK: Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking. Neuropsychopharmacology. 2009 Sep;34 (10) :2218-26. Epub 2009 May 13. PMID: 19440191


Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP and Staley JK: beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry. 2009 Jun;66 (6) :666-76. PMID: 19487632


Hausner SH, Alagille D, Koren AO, Amici L, Staley JK, Cosgrove KP, Baldwin RM and Tamagnan GD: Synthesis of 5- and 6-substituted 2-(4-dimethylaminophenyl)-1,3-benzoxazoles and their in vitro and in vivo evaluation as imaging agents for amyloid plaque. Bioorg Med Chem Lett. 2009 Jan 15;19 (2) :543-5. Epub 2008 May 15. PMID: 19081717


Rabinovich PM, Komarovskaya ME, Wrzesinski SH, Alderman JL, Budak-Alpdogan T, Karpikov A, Guo H, Flavell RA, Cheung NK, Weissman SM and Bahceci E: Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes. Hum Gene Ther. 2009 Jan;20 (1) :51-61. PMID: 19025415

Planeta-Wilson B, Yan J, Mulnix T and Carson RE: Quantitative Accuracy of HRRT List-mode Reconstructions: Effect of Low Statistics. IEEE Nucl Sci Symp Conf Rec (1997). 2008 Oct 1;2008 :5121-5124. PMID: 20617118


Lian Z, Karpikov A, Lian J, Mahajan MC, Hartman S, Gerstein M, Snyder M and Weissman SM: A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylation. Genome Res. 2008 Aug;18 (8) :1224-37. Epub 2008 May 16. PMID: 18487515


Czermak C, Staley JK, Kasserman S, Bois F, Young T, Henry S, Tamagnan GD, Seibyl JP, Krystal JH and Neumeister A: beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder. Int J Neuropsychopharmacol. 2008 May;11 (3) :419-24. Epub 2008 Jan 11. PMID: 18190729


Yan J, Planeta-Wilson B and Carson RE: Direct 4D List Mode Parametric Reconstruction for PET with a Novel EM Algorithm. IEEE Nucl Sci Symp Conf Rec (1997). 2008;4774103 :3625-3628. PMID: 20628540


Bois F, Baldwin RM, Amici L, Al-Tikriti MS, Kula N, Baldessarini R, Innis RB, Staley JK and Tamagnan GD: Synthesis, radiolabeling and baboon SPECT imaging of 2beta-carbomethoxy-3beta-(3'-[(123)I]iodophenyl)tropane ([(123)I]YP256) as a serotonin transporter radiotracer. Nucl Med Biol. 2008 Jan;35 (1) :53-9. PMID: 18158943

McCarthy TL, Hochberg RB, Labaree DC and Centrella M: 3-ketosteroid reductase activity and expression by fetal rat osteoblasts. J Biol Chem. 2007 Nov 23;282 (47) :34003-12. Epub 2007 Sep 28. PMID: 17905737


Cosgrove KP, Mazure CM and Staley JK: Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry. 2007 Oct 15;62 (8) :847-55. Epub 2007 Jun 4. PMID: 17544382


Cosgrove KP, Mitsis EM, Bois F, Frohlich E, Tamagnan GD, Krantzler E, Perry E, Maciejewski PK, Epperson CN, Allen S, O'malley S, Mazure CM, Seibyl JP, van Dyck CH and Staley JK: 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase. J Nucl Med. 2007 Oct;48 (10) :1633-40. Epub 2007 Sep 14. PMID: 17873128


Ariyan S, Ali-Salaam P, Cheng DW and Truini C: Reliability of lymphatic mapping after wide local excision of cutaneous melanoma. Ann Surg Oncol. 2007 Aug;14 (8) :2377-83. Epub 2007 Jun 1. PMID: 17541771


Huang Y and Williams WA: Enhanced selective serotonin re-uptake inhibitors as antidepressants: 2004 - 2006. Expert Opin Ther Pat. 2007 Aug;17 (8) :889-907. PMID: 20144065


Brian SR, Cheng DW and Goldberg PA: Unusual case of amiodarone-induced thyrotoxicosis: "illicit" use of a technetium scan to diagnose a transiently toxic thyroid nodule. Endocr Pract. 2007 Jul-Aug;13 (4) :413-6. PMID: 17669720


Wang TS, Cheng DW and Udelsman R: Contemporary imaging for thyroid cancer. Surg Oncol Clin N Am. 2007 Apr;16 (2) :431-45. PMID: 17560521


Mitsis EM, Cosgrove KP, Staley JK, Frohlich EB, Bois F, Tamagnan GD, Estok KM, Seibyl JP and Van Dyck CH: [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain. Ann N Y Acad Sci. 2007 Feb;1097 :168-70. PMID: 17413019

Shetty-Alva N and Cheng DW: Low-dose P32 therapy in essential thrombocythemia. Clin Nucl Med. 2006 Dec;31 (12) :790-1. PMID: 17117074


Neumeister A, Carson R, Henry S, Planeta-Wilson B, Binneman B, Maguire RP, Luckenbaugh DA, D'Souza C, Krystal JH and Frost JJ: Cerebral metabolic effects of intravenous glycine in healthy human subjects. J Clin Psychopharmacol. 2006 Dec;26 (6) :595-9. PMID: 17110816


Bennacef I, Haile CN, Schmidt A, Koren AO, Seibyl JP, Staley JK, Bois F, Baldwin RM and Tamagnan G: Synthesis and receptor binding studies of halogenated N,N-dialkylel-(2-phenyl-1H-indol-3-yl)glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET. Bioorg Med Chem. 2006 Nov 15;14 (22) :7582-91. PMID: 16908169


Bois F, Baldwin RM, Kula NS, Baldessarini RJ, Al Tikriti M, Innis RB and Tamagnan GD: Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine. Bioorg Med Chem Lett. 2006 Oct 1;16 (19) :5222-5. PMID: 16908151


Lane M, Esterlis I, Tello A, Vesga-Lopez O, Zonana H and Jean-Baptiste M: Using the internet for clinical information gathering about unidentified psychiatric patients. J Psychiatr Pract. 2006 Sep;12 (5) :324-6. PMID: 16998422


Staley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S and van Dyck CH: Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. J Neurosci. 2006 Aug 23;26 (34) :8707-14. PMID: 16928859


Kuo PH, Cooper DL and Cheng DW: Recurrence of lymphoma presenting as asymmetrically increased testicular activity on FDG-PET/CT. Semin Nucl Med. 2006 Jan;36 (1) :105-7. PMID: 16356799

Kuo PH, Cheng DW and Sadar R: Diagnosis of septic joint in an immunosuppressed patient by twenty-four hour delayed imaging with Tc-99m HMPAO labeled white blood cell scan. Clin Nucl Med. 2005 Dec;30 (12) :808-9. PMID: 16319641


Kuo PH and Cheng DW: Artifactual spinal metastases imaged by PET/CT: a case report. J Nucl Med Technol. 2005 Dec;33 (4) :230-1. PMID: 16322123


Pappu S, Donovan P, Cheng D and Udelsman R: Sestamibi scans are not all created equally. Arch Surg. 2005 Apr;140 (4) :383-6. PMID: 15841562


Zhang JX, Labaree DC and Hochberg RB: Nonpolar and short side chain groups at C-11beta of estradiol result in antiestrogens. J Med Chem. 2005 Mar 10;48 (5) :1428-47. PMID: 15743187

Zhang JX, Labaree DC, Mor G and Hochberg RB: Estrogen to antiestrogen with a single methylene group resulting in an unusual steroidal selective estrogen receptor modulator. J Clin Endocrinol Metab. 2004 Jul;89 (7) :3527-35. PMID: 15240642


Bois F, Baldwin RM, Kula NS, Baldessarini RJ, Innis RB and Tamagnan G: Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorg Med Chem Lett. 2004 May 3;14 (9) :2117-20. PMID: 15080991


Centrella M, McCarthy TL, Chang WZ, Labaree DC and Hochberg RB: Estren (4-estren-3alpha,17beta-diol) is a prohormone that regulates both androgenic and estrogenic transcriptional effects through the androgen receptor. Mol Endocrinol. 2004 May;18 (5) :1120-30. Epub 2004 Feb 5. PMID: 14764654

Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY and Hochberg RB: Synthesis and evaluation of B-, C-, and D-ring-substituted estradiol carboxylic acid esters as locally active estrogens. J Med Chem. 2003 May 8;46 (10) :1886-904. PMID: 12723952