2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometrium
2010
In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer. Discover Oncology 2010, 1: 146-155. PMID: 21761357, PMCID: PMC3140020, DOI: 10.1007/s12672-010-0015-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzhydryl CompoundsBlotting, WesternCarcinogensCell Line, TumorDiethylstilbestrolEndocrine DisruptorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticFemaleGene ExpressionHistone-Lysine N-MethyltransferaseHumansMammary Neoplasms, ExperimentalMicePhenolsPolycomb Repressive Complex 2PregnancyPrenatal Exposure Delayed EffectsReverse Transcriptase Polymerase Chain ReactionConceptsUtero exposureMCF-7 cellsEZH2 expressionMammary tissueMammary glandBreast cancerBreast cancer riskEffects of BPAAdult mammary tissueEZH2 protein expressionPersistent epigenetic changesZeste homolog 2DES exposureFetal exposureEZH2 mRNA expressionBreast neoplasiaNeoplastic changesCancer riskBPA treatmentEndocrine-disrupting chemicalsAdult womenDevelopmental programmingMRNA expressionUteroMice