PD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect
Hu Q, Fielder C, Huh W, Kassim A, Kim T. PD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect. Transplantation And Cellular Therapy 2024, 30: s253. DOI: 10.1016/j.jtct.2023.12.336.Peer-Reviewed Original ResearchMyeloid antigen-presenting cellsHost antigen-presenting cellsAntigen-presenting cellsBone marrow transplantationMyeloid-derived suppressor cellsAllogeneic T cell proliferationAcute GVHDAcute GVHD symptomsGraft-versus-leukemiaPD-1HT cell proliferationHost miceT cellsBMT modelIsotype controlGraft-versus-leukemia (GVLSuppress acute graft-versus-host diseaseMHC-mismatched bone marrow transplantationAcute graft-versus-host diseaseT cell priming phaseGraft-versus-host diseaseMismatched bone marrow transplantationMyeloid antigen presenting cellsAcute GVHD treatmentDonor T cells