2001
Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets
Zawalich W, Zawalich K, Tesz G, Sterpka J, Philbrick W. Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets. AJP Endocrinology And Metabolism 2001, 280: e720-e728. PMID: 11287354, DOI: 10.1152/ajpendo.2001.280.5.e720.Peer-Reviewed Original Research
2000
βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System
Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J, Zhang J, Philbrick W, Slepnev V, Ort T, Solimena M. βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System. Journal Of Cell Biology 2000, 151: 985-1002. PMID: 11086001, PMCID: PMC2174349, DOI: 10.1083/jcb.151.5.985.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnkyrinsAutoantigensAxonsBlood ProteinsBrain ChemistryChromosomesCloning, MolecularCOS CellsCytoplasmCytoskeletonDiabetic NeuropathiesGene ExpressionHippocampusHumansIslets of LangerhansMaleMembrane ProteinsMiceMolecular Sequence DataNerve Tissue ProteinsPhosphoproteinsProtein Structure, TertiaryProtein Tyrosine PhosphatasesRanvier's NodesRatsRats, Sprague-DawleyReceptor-Like Protein Tyrosine Phosphatases, Class 8RNA, MessengerSciatic NerveSignal TransductionSodium ChannelsSpectrinConceptsPleckstrin homology domainHomology domainBetaIV spectrinActin-binding domainAxon initial segmentPutative SH3Alternative splicingSpectrin geneSpectrin repeatsDetergent extractabilityCell adhesion moleculeNodes of RanvierSubcellular fractionationTerminal halfAdditional isoformsDistinct isoformsLong isoformNorthern blotSpectrinAbundant expressionΒIV-spectrinIsoformsSpectrin antibodiesEmbryonic day 19Initial segmentHepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*
Garcia-Ocaña A, Takane K, Syed M, Philbrick W, Vasavada R, Stewart A. Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*. Journal Of Biological Chemistry 2000, 275: 1226-1232. PMID: 10625667, DOI: 10.1074/jbc.275.2.1226.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorRat insulin II promoterBeta-cell proliferationDiabetogenic effectMild hypoglycemiaIslet massInsulin contentOverexpression of HGFIslet numberInsulin productionBeta-cell replication rateRole of HGFHepatocyte growth factor overexpressionProliferation of isletsBeta-cell massCell proliferationGrowth factor overexpressionMesenchyme-derived cellsPancreatic areaCell replication ratesFasting statesNormal littermatesTransgenic miceHGF mRNAIslet cells
1996
Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗)
Vasavada R, Cavaliere C, D'Ercole A, Dann P, Burtis W, Madlener A, Zawalich K, Zawalich W, Philbrick W, Stewart A. Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗). Journal Of Biological Chemistry 1996, 271: 1200-1208. PMID: 8557651, DOI: 10.1074/jbc.271.2.1200.Peer-Reviewed Original ResearchConceptsRat insulin II promoterInsulin secretionIslet massPancreatic isletsNormal littermatesHormone-related proteinBlood glucose valuesTotal islet massIslet perifusion studiesNormal physiologic roleInappropriate hyperinsulinemiaParathyroid hormoneIslet hyperplasiaInsulin concentrationsTotal islet numberAutocrine roleGlucose homeostasisPerifusion studiesTransgenic miceGlucose valuesIslet numberIslet cellsPhysiologic rolePTHrPMice
1995
Cell Type-specific Secretion of Parathyroid Hormone-related Protein via the Regulated versus the Constitutive Secretory Pathway∗
Plawner L, Philbrick W, Burtis W, Broadus A, Stewart A. Cell Type-specific Secretion of Parathyroid Hormone-related Protein via the Regulated versus the Constitutive Secretory Pathway∗. Journal Of Biological Chemistry 1995, 270: 14078-14084. PMID: 7775469, DOI: 10.1074/jbc.270.23.14078.Peer-Reviewed Original ResearchConceptsNon-neuroendocrine cellsConstitutive pathwayRegulated pathwayCell typesRegulated secretory pathwayNeuroendocrine cellsNeuroendocrine cell typesDaughter peptidesSecretory pathwayRegulated fashionMature secretory formsConstitutive fashionSecretory formPathwayHormone-related proteinProteinCellsPolypeptide hormonesPathway usePeptidesParathyroid hormone-related proteinSecretion of PTHrPSecretionSecretory