2001
Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1
Wysolmerski J, Cormier S, Philbrick W, Dann P, Zhang J, Roume J, Delezoide A, Silve C. Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-1794. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.Peer-Reviewed Original ResearchMeSH KeywordsBreastCongenital AbnormalitiesEmbryonic and Fetal DevelopmentFemaleFetusHumansMaleOsteochondrodysplasiasProtein IsoformsReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid HormoneReference ValuesToothTooth, ImpactedConceptsParathyroid hormoneHuman breastBreast developmentType 1 PTH/PTHrP receptorBlomstrand chondrodysplasiaPTH/PTHrP receptorAbnormal breast developmentBone formationTooth developmentNormal human fetusesTooth impactionPTHrP receptorEndochondral bone formationTransgenic miceAlveolar boneHuman fetusesEndochondral bone developmentBreastSevere abnormalitiesEpithelial-mesenchymal interactionsLethal formMammary glandFetusesBone developmentTeeth
1998
Parathyroid hormone-related protein is required for tooth eruption
Philbrick W, Dreyer B, Nakchbandi I, Karaplis A. Parathyroid hormone-related protein is required for tooth eruption. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11846-11851. PMID: 9751753, PMCID: PMC21728, DOI: 10.1073/pnas.95.20.11846.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceTooth eruptionEruption pathwayPTHrP expressionType I PTH/PTHrP receptorEnamel epitheliumPTH/PTHrP receptorOverexpression of PTHrPHormone-related proteinMonths of ageNormal tooth developmentParathyroid hormoneBone resorptionPTHrP receptorPTHrP mRNAKnockout miceTransgenic miceAlveolar boneDental mesenchymeLevel of expressionMiceBone formationSkeletal abnormalitiesTooth developmentKeratin 14
1995
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines
Orloff J, Kats Y, Urena P, Schipani E, Vasavada R, Philbrick W, Behal A, Abou-Samra A, Segre G, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology 1995, 136: 3016-3023. PMID: 7789327, DOI: 10.1210/endo.136.7.7789327.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernCarcinoma, Squamous CellCyclic AMPDNA ProbesGene ExpressionHumansKeratinocytesMolecular Sequence DataParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsProteinsRadioligand AssayReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid HormoneRNA, MessengerTransfectionTumor Cells, CulturedConceptsSquamous carcinoma cell linesSquamous cell linesPTH/PTHrP receptorType I receptorCarcinoma cell linesI receptorSquamous cellsPTHrP receptorCell linesCommon PTH/PTHrP receptorParathyroid hormone-related proteinType INormal keratinocytesAmino-terminal PTHMessenger RNAHormone-related proteinReceptor messenger RNAPTH target tissuesIntracellular cAMP responseSqCC/Y1 cellsSquamous carcinoma cellsStrong RNA signalsReceptor complementary DNAType II receptorIntracellular calcium