2018
Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons
Li D, Musante V, Zhou W, Picciotto MR, Nairn AC. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. Journal Of Biological Chemistry 2018, 293: 11179-11194. PMID: 29802198, PMCID: PMC6052221, DOI: 10.1074/jbc.ra117.001519.Peer-Reviewed Original ResearchConceptsSerine/threonine phosphatase PP2AStriatin-interacting phosphataseRNA knockdown approachB subunitSTRIPAK complexPhosphatase PP2AProtein phosphataseMultiprotein complexesKnockdown approachStriatin familyMutant constructsStriatal neuronal culturesPP2ANeuronal developmentPrimary striatal neuronal culturesDendritic phenotypeKnockdown modelSynapse formationSubunitsSpine developmentSelective roleReduced expressionNeuron maturationNeuronal culturesStriatal neurons
2015
Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice
Mineur YS, Bentham MP, Zhou WL, Plantenga ME, McKee SA, Picciotto MR. Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. Psychopharmacology 2015, 232: 3539-3549. PMID: 26146014, PMCID: PMC4561580, DOI: 10.1007/s00213-015-4001-3.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsPaired-pulse ratioC-Fos immunoreactivityPrefrontal cortexSwim testBrain areasRobust antidepressant-like effectsBrain regionsSex differencesMale C57BL/6J miceDepression-like behaviorEffects of guanfacineAcetylcholinesterase inhibitor physostigmineLight/dark boxBaseline sex differencesC-fos expressionDepression-like stateCritical brain regionsDifferent brain areasSex-specific changesAntidepressant efficacyCholinergic controlInhibitor physostigmineC57BL/6J miceAgonist guanfacine
2005
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
Zhou W, Wu J, Wu Q, Wang J, Zhou Y, Zhou R, He P, Li X, Yang Y, Zhang Y, Li Y, Zuo J. A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo. Acta Pharmacologica Sinica 2005, 26: 1352-1358. PMID: 16225758, DOI: 10.1111/j.1745-7254.2005.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory Agents, Non-SteroidalArtemisininsCell ProliferationCells, CulturedCytokinesDose-Response Relationship, DrugHemolysisHypersensitivity, DelayedImmunosuppressive AgentsInhibitory Concentration 50Interferon-gammaInterleukin-12Lymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CMice, Inbred C57BLSuccinatesConceptsDelayed-type hypersensitivityMixed lymphocyte reactionProliferation of splenocytesSheep red blood cellsImmunosuppressive agentsCytokine productionT-cell-mediated delayed-type hypersensitivityImmunosuppressive activityVivo immune activityProinflammatory cytokine productionIL-2 secretionNovel artemisinin derivativesEnzyme-linked immunosorbentDose-dependent mannerStrong immunosuppressive activityPotential immunosuppressive agentsRed blood cellsLymphocyte reactionImmunosuppressive effectsQuantitative hemolysisImmune activityMouse modelArtemisinin derivativesConA stimulationBlood cellsInhibition of S-Adenosyl-l-homocysteine Hydrolase Induces Immunosuppression
Wu Q, Fu Y, Zhou W, Wang J, Feng Y, Liu J, Xu J, He P, Zhou R, Tang W, Wang G, Zhou Y, Yang Y, Ding J, Li X, Chen X, Yuan C, Lawson B, Zuo J. Inhibition of S-Adenosyl-l-homocysteine Hydrolase Induces Immunosuppression. Journal Of Pharmacology And Experimental Therapeutics 2005, 313: 705-711. PMID: 15640397, DOI: 10.1124/jpet.104.080416.Peer-Reviewed Original ResearchMeSH KeywordsAdenosylhomocysteinaseAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenCell SurvivalDose-Response Relationship, DrugDown-RegulationEnzyme ActivationEnzyme InhibitorsFemaleGrowth InhibitorsImmunosuppressive AgentsLymphocyte Culture Test, MixedMaleMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLConceptsTHP-1 cellsImmunosuppressive effectsTumor necrosis factor-alpha productionDelayed-type hypersensitivity reactionS-adenosyl-L-homocysteine hydrolaseNecrosis factor-alpha productionLevels of CD80IL-12 productionMixed lymphocyte reactionT cell inhibitionHuman monocytic THP-1 cellsThioglycollate-stimulated peritoneal macrophagesT cell functionT cell proliferationImmunosuppressive therapeutic agentsT cell costimulationMonocytic THP-1 cellsDose-dependent mannerImmunologic effectsIL-12Lymphocyte reactionHypersensitivity reactionsCytokine outputMacrophage activationType III inhibitor