2017
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short SM, Oikonomou KD, Zhou WL, Acker CD, Popovic MA, Zecevic D, Antic SD. The stochastic nature of action potential backpropagation in apical tuft dendrites. Journal Of Neurophysiology 2017, 118: 1394-1414. PMID: 28566465, PMCID: PMC5558024, DOI: 10.1152/jn.00800.2016.Peer-Reviewed Original ResearchConceptsDendritic CaPyramidal neuronsApical tuftCortical pyramidal neuronsAction potential backpropagationRat brain slicesSpontaneous synaptic inputsDifferent cortical layersVoltage-gated CaAP backpropagationAP burstsGlutamate iontophoresisSynaptic contactsSomatic APsApical trunkAP frequencyBrain slicesDendritic physiologySynaptic inputsCortical layersChannel inactivationLocal NaNeuronsSpike-timing dependent plasticityTrials
2014
Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex
Moore A, Zhou W, Sirois C, Belinsky G, Zecevic N, Antic S. Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3919-e3928. PMID: 25197082, PMCID: PMC4169969, DOI: 10.1073/pnas.1405253111.Peer-Reviewed Original ResearchConceptsHuman fetal cortexAction potential firingFetal cortexSP neuronsSpontaneous activitySpontaneous depolarizationsYoung postmitotic neuronsGlycinergic synaptic transmissionConnexin-based gap junctionsElectrical activityAcute cortical slicesSpontaneous electrical activityWhole-cell recordingsConnexin hemichannelsGap junctionsHuman subplate neuronsPresence of connexinsSubplate neuronsSecond trimesterCortical slicesSynaptic contactsSynaptic transmissionImmunohistochemical analysisSP zonePostmitotic neurons
2012
Dopaminergic Regulation of Dendritic Calcium: Fast Multisite Calcium Imaging
Zhou W, Oikonomou K, Short S, Antic S. Dopaminergic Regulation of Dendritic Calcium: Fast Multisite Calcium Imaging. Methods In Molecular Biology 2012, 964: 123-138. PMID: 23296782, DOI: 10.1007/978-1-62703-251-3_9.Peer-Reviewed Original ResearchConceptsDendritic calcium transientsCalcium transientsDendritic treeNormal cortical functionIndividual cortical neuronsElaborate dendritic treesNeocortical pyramidal neuronsSomatic action potentialsDendritic calciumGlutamatergic inputsPyramidal neuronsDopaminergic drugsDopaminergic regulationCortical neuronsDopaminergic modulationCortical functionExogenous dopamineSynaptic integrationAction potentialsCalcium imagingDopamine toneDendritic compartmentsDopaminergic signalsDendritic branchesCalcium fluctuationsRapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons
Zhou W, Antic S. Rapid dopaminergic and GABAergic modulation of calcium and voltage transients in dendrites of prefrontal cortex pyramidal neurons. The Journal Of Physiology 2012, 590: 3891-3911. PMID: 22641784, PMCID: PMC3476639, DOI: 10.1113/jphysiol.2011.227157.Peer-Reviewed Original ResearchConceptsDendritic calcium transientsAction potentialsDopamine effectsSame dendriteCalcium transientsPrefrontal cortex pyramidal neuronsT-type calcium channel blockersDendritic calcium influxCortex pyramidal neuronsCalcium channel blockersMidbrain dopaminergic neuronsCalcium-sensitive dyeAP backpropagationDopaminergic stimulationGABAergic modulationPyramidal neuronsDopaminergic neuronsPulses of GABAD1 antagonistDopamine applicationDopaminergic suppressionDopaminergic inputSomatic excitabilityD1 agonistChannel blockers
2007
Voltage and calcium transients in basal dendrites of the rat prefrontal cortex
Milojkovic B, Zhou W, Antic S. Voltage and calcium transients in basal dendrites of the rat prefrontal cortex. The Journal Of Physiology 2007, 585: 447-468. PMID: 17932150, PMCID: PMC2375496, DOI: 10.1113/jphysiol.2007.142315.Peer-Reviewed Original ResearchConceptsDendritic plateau potentialsCalcium transientsPlateau potentialsBasal dendritesDendritic branchesSmall-amplitude depolarizationThin basal dendritesDendritic calcium transientsGlutamatergic synaptic inputsDendritic calcium dynamicsRat prefrontal cortexHigher cortical functionsThin dendritic branchesNeocortical pyramidal cellsSame dendritic branchCalcium distributionDendritic excitabilitySynaptic contactsIndividual dendritic branchesExcitatory inputsPyramidal cellsCortical functionSynaptic inputsSame dendriteSynaptic integration