2017
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short SM, Oikonomou KD, Zhou WL, Acker CD, Popovic MA, Zecevic D, Antic SD. The stochastic nature of action potential backpropagation in apical tuft dendrites. Journal Of Neurophysiology 2017, 118: 1394-1414. PMID: 28566465, PMCID: PMC5558024, DOI: 10.1152/jn.00800.2016.Peer-Reviewed Original ResearchConceptsDendritic CaPyramidal neuronsApical tuftCortical pyramidal neuronsAction potential backpropagationRat brain slicesSpontaneous synaptic inputsDifferent cortical layersVoltage-gated CaAP backpropagationAP burstsGlutamate iontophoresisSynaptic contactsSomatic APsApical trunkAP frequencyBrain slicesDendritic physiologySynaptic inputsCortical layersChannel inactivationLocal NaNeuronsSpike-timing dependent plasticityTrials
2014
Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex
Moore A, Zhou W, Sirois C, Belinsky G, Zecevic N, Antic S. Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3919-e3928. PMID: 25197082, PMCID: PMC4169969, DOI: 10.1073/pnas.1405253111.Peer-Reviewed Original ResearchConceptsHuman fetal cortexAction potential firingFetal cortexSP neuronsSpontaneous activitySpontaneous depolarizationsYoung postmitotic neuronsGlycinergic synaptic transmissionConnexin-based gap junctionsElectrical activityAcute cortical slicesSpontaneous electrical activityWhole-cell recordingsConnexin hemichannelsGap junctionsHuman subplate neuronsPresence of connexinsSubplate neuronsSecond trimesterCortical slicesSynaptic contactsSynaptic transmissionImmunohistochemical analysisSP zonePostmitotic neurons
2011
Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro
Moore A, Zhou W, Jakovcevski I, Zecevic N, Antic S. Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro. Journal Of Neuroscience 2011, 31: 2391-2398. PMID: 21325506, PMCID: PMC3564513, DOI: 10.1523/jneurosci.3886-10.2011.Peer-Reviewed Original ResearchConceptsAction potential firingSpontaneous electrical activitySP neuronsPlateau depolarizationsHuman fetal neuronsElectrical activityHuman fetal cortexFunctional synaptic contactsHuman cerebral cortexSpontaneous network activitySlow-wave sleepHuman postmortem tissueSlow oscillatory patternsGABA ionotropic receptorsHuman subplate neuronsFetal neuronsSubplate neuronsCerebral cortexGestational weeksSynaptic contactsFetal cortexPostsynaptic potentialsCortical neuronsAdult neocortexSynaptic inputs
2010
Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons
Moore A, Zhou W, Potapenko E, Kim E, Antic S. Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons. Brain Research 2010, 1370: 1-15. PMID: 21059342, PMCID: PMC3019254, DOI: 10.1016/j.brainres.2010.10.111.Peer-Reviewed Original ResearchConceptsPyramidal neuronsMidbrain dopaminergic neuronsPrefrontal cortexDopaminergic neuronsLayer 5 pyramidal neuronsRat medial prefrontal cortexAction potential firing ratePFC pyramidal neuronsPrefrontal pyramidal neuronsD1-like receptorsDirect synaptic contactsAction potential firingMedial prefrontal cortexDose-dependent responseDopaminergic stimulationIontophoretic pulsesCortical excitabilitySynaptic contactsDopaminergic agonistsSevere depressionPyramidal cellsTransient physiological changesBrain slicesAction potentialsCell bodiesThe decade of the dendritic NMDA spike
Antic S, Zhou W, Moore A, Short S, Ikonomu K. The decade of the dendritic NMDA spike. Journal Of Neuroscience Research 2010, 88: 2991-3001. PMID: 20544831, PMCID: PMC5643072, DOI: 10.1002/jnr.22444.Peer-Reviewed Original ResearchConceptsDendritic NMDA spikesNMDA spikesPyramidal cellsPlateau potentialsActive synaptic inputsApical tuft dendritesGlutamatergic synaptic contactsThick apical dendritesLong-term synaptic modificationsNeuronal cell bodiesCortical pyramidal cellsSlow-wave sleepCortical UP statesDendritic regenerative potentialsCortical information processingBasal dendritesPyramidal neuronsApical dendritesSynaptic contactsApical trunkTuft dendritesSynaptic inputsProximal segmentThin dendritesAwake animals
2008
Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons
Zhou W, Yan P, Wuskell J, Loew L, Antic S. Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons. European Journal Of Neuroscience 2008, 27: 923-936. PMID: 18279369, PMCID: PMC2715167, DOI: 10.1111/j.1460-9568.2008.06075.x.Peer-Reviewed Original ResearchConceptsBasilar dendritic treeBasal dendritesRat prefrontal cortexPyramidal neuronsAction potentialsDendritic treePrefrontal cortical pyramidal neuronsLayer 5 pyramidal neuronsPrefrontal cortexSodium action potentialsBackpropagating action potentialsCortical pyramidal neuronsAction potential backpropagationNeocortical pyramidal neuronsSomatic action potentialsCortical pyramidal cellsDistal dendritic segmentsHigh-frequency burstsVoltage-sensitive dye imaging techniqueAP backpropagationSynaptic contactsIndividual dendritic branchesPyramidal cellsNeuronal outputCalcium transients
2007
Voltage and calcium transients in basal dendrites of the rat prefrontal cortex
Milojkovic B, Zhou W, Antic S. Voltage and calcium transients in basal dendrites of the rat prefrontal cortex. The Journal Of Physiology 2007, 585: 447-468. PMID: 17932150, PMCID: PMC2375496, DOI: 10.1113/jphysiol.2007.142315.Peer-Reviewed Original ResearchConceptsDendritic plateau potentialsCalcium transientsPlateau potentialsBasal dendritesDendritic branchesSmall-amplitude depolarizationThin basal dendritesDendritic calcium transientsGlutamatergic synaptic inputsDendritic calcium dynamicsRat prefrontal cortexHigher cortical functionsThin dendritic branchesNeocortical pyramidal cellsSame dendritic branchCalcium distributionDendritic excitabilitySynaptic contactsIndividual dendritic branchesExcitatory inputsPyramidal cellsCortical functionSynaptic inputsSame dendriteSynaptic integration