2016
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea
Jafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.Peer-Reviewed Original ResearchConceptsHypertensive OSAObstructive sleep apneaFlow-mediated vasodilationEndothelial dysfunctionYKL-40Sleep apneaEndothelial-dependent vasodilatory capacityNormotensive OSAChitinase-3-like protein 1Sleep-disordered breathingCharacteristic curve analysisChitinase-3-like proteinHypertension independentVasodilatory capacityCardiovascular morbidityEndothelial functionHypertension statusRisk factorsPrevalent disorderHypertensionNegative correlationDysfunctionPotential biomarkersSignificant negative correlationCurve analysis
2015
Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2004
Is sleep apnea a risk factor for stroke? A critical analysis.
Mohsenin V. Is sleep apnea a risk factor for stroke? A critical analysis. Minerva Medica 2004, 95: 291-305. PMID: 15334043.Peer-Reviewed Original ResearchConceptsModifiable risk factorsSleep apneaRisk factorsSleep-related breathing disordersSerious long-term disabilityDevelopment of strokeObstructive sleep apneaCoronary artery diseaseLong-term disabilityManagement of strokePathogenesis of strokeRecent large epidemiological studiesCause of deathLarge epidemiological studiesArterial hypertensionNeurologic recoveryAcute strokeArtery diseaseHemodynamic changesSignificant morbidityBreathing disordersProspective studyCardiac diseaseTherapeutic approachesApnea
2001
Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions
Mohsenin V. Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions. CHEST Journal 2001, 120: 1442-1447. PMID: 11713117, DOI: 10.1378/chest.120.5.1442.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingUpper airway sizeUpper airway dimensionsSleep apneaAirway sizeMale patientsFemale patientsAirway dimensionsUpper airwayEvaluation of SDBPrevalence of OSAPharyngeal sizeGreater total body fatMild obstructive sleep apneaUpper airway resistance syndromeSevere obstructive sleep apneaPharyngeal muscle toneUpper airway patencyEffect of obesityExcessive daytime sleepinessSimilar clinical presentationUpper airway narrowingDifferent pathogenetic mechanismsMajor risk factorSleep-Related Breathing Disorders and Risk of Stroke
Mohsenin V. Sleep-Related Breathing Disorders and Risk of Stroke. Stroke 2001, 32: 1271-1278. PMID: 11387486, DOI: 10.1161/01.str.32.6.1271.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersTransient ischemic attackRisk of strokeBreathing disordersRisk factorsSleep apnea disorderIschemic attackApnea disorderHematologic changesHigh prevalenceNormal sleep stateModifiable risk factorsPresence of hypertensionRecent large epidemiological studiesPossible pathogenetic mechanismsLarge epidemiological studiesDiurnal hypertensionCerebral perfusionSignificant morbidityCerebral hemodynamicsPathogenetic mechanismsEpidemiological studiesStrokeHypertensionPatients