2024
Distribution of HPV 16/18 by Ethnicity and Correlation with HPV Vaccination Status
Abi-Raad R, Krishnamurti U. Distribution of HPV 16/18 by Ethnicity and Correlation with HPV Vaccination Status. Journal Of The American Society Of Cytopathology 2024, 13: s29. DOI: 10.1016/j.jasc.2024.08.052.Peer-Reviewed Original ResearchClinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer.
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 10668969241256109. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival timeChanging digital and telecytology practices post COVID-19 comparing ASC survey results from 2016 to 2023
Chen-Yost H, Bammert C, Hao W, Heymann J, Lin D, Marotti J, Waraksa-Deutsch T, Huang M, Krishnamurti U, Lin O, Ly A, Moatamed N, Pantanowitz L, Roy-Chowdhuri S. Changing digital and telecytology practices post COVID-19 comparing ASC survey results from 2016 to 2023. Journal Of The American Society Of Cytopathology 2024, 13: 194-204. PMID: 38582697, DOI: 10.1016/j.jasc.2024.02.004.Peer-Reviewed Original Research
2023
HER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience
Podany P, Golastani R, Zhan H, Liang Y, Harigopal M, Krishnamurti U. HER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience. American Journal Of Clinical Pathology 2023, 160: s9-s10. DOI: 10.1093/ajcp/aqad150.021.Peer-Reviewed Original ResearchLow HER2 expressionInvasive breast carcinomaIHC scoreHER2 expressionGroup 1Group 3HER2 immunohistochemistryHER2 testingGroup 2HER2 FISHGroup 4ASCO/CAP guidelinesGroup 5Single institutional experienceRecent clinical trialsStandard of careASCO/CAP 2018 guidelinesHER2/CEP17 ratioEquivocal HER2HER2 positivityTrastuzumab deruxtecanMore patientsCAP guidelinesPatient eligibilityCase reportAn Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy
Mudrinich S, Nguyen M, Blemur D, Wang X, Wang Y, Krishnamurti U, Mosunjac M, Flowers L. An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. Journal Of Lower Genital Tract Disease 2023, 28: 101-106. PMID: 38117565, DOI: 10.1097/lgt.0000000000000773.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirus (hrHPV) testingLow CD4 countRisk factorsTriage toolAnal cytologyCD4 countTransgender womenAdult cisgender menHigh-Resolution AnoscopyHuman papillomavirus testingCisgender menPredictive risk factorsRetrospective cohort studySignificant risk factorsSociodemographic risk factorsNegative predictive valueNovel triage toolHrHPV positivityUnderwent cytologyHrHPV testingCohort studyAnal neoplasiaScreening patternsPredictive valueHIVBreast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Original ResearchBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumorsThe correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas
Moreira-Dinzey J, Zhan H, Rozenblit M, Krishnamurti U, Harigopal M, Zhong M, Liang Y. The correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas. Human Pathology 2023, 137: 56-62. PMID: 37127079, DOI: 10.1016/j.humpath.2023.04.017.Peer-Reviewed Original ResearchConceptsMetastatic tumorsBreast carcinomaGenetic aberrationsPR statusPrimary tumorBreast cancerControl groupER/PR statusEstrogen receptor-positive breast carcinomasER-positive breast cancerER positivity rateMetastatic breast cancerProgesterone receptor statusMetastatic breast carcinomaMore liver metastasesPrimary breast carcinomaWild-type groupEstrogen receptor 1 geneReceptor 1 geneWild-type controlsLiver metastasesReceptor statusClinicopathological featuresER expressionControl tumors
2022
Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital
Dababneh M, Birdsong G, Mosunjac M, Krishnamurti U. Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital. Journal Of The American Society Of Cytopathology 2022, 12: 120-125. PMID: 36585313, DOI: 10.1016/j.jasc.2022.11.005.Peer-Reviewed Original ResearchConceptsHR-HPV genotypesAfrican American womenIntraepithelial lesionsPap testHigh-grade squamous intraepithelial lesion casesHigh-grade squamous intraepithelial lesionsCommon high-risk HPVHPV molecular testingHigh-risk HPVSquamous intraepithelial lesionsCervical Pap testBethesda classification systemCommon human papillomavirusCervical Papanicolaou smearsInner-city hospitalSecondary prevention methodsAmerican womenHR-HPVHPV vaccineHPV genotypesCervical cancerHuman papillomavirusPapanicolaou smearsAfrican American populationLesion casesFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokersNeighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities
Gohar J, Do W, Miller-Kleinhenz J, Conneely K, Krishnamurti U, D’Angelo O, Gogineni K, Torres M, Gabram-Mendola S, McCullough L. Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast Cancer Research And Treatment 2022, 191: 653-663. PMID: 34978015, DOI: 10.1007/s10549-021-06430-1.Peer-Reviewed Original ResearchConceptsNeighborhood-level factorsCause mortalityMultivariable Cox proportional hazards modelsCox proportional hazards modelCancer outcome disparitiesBreast cancer outcomesTumor methylationProportional hazards modelNon-Hispanic blacksArea-level factorsCancer outcomesFalse discovery rate thresholdBody of evidenceCancer disparitiesBreast cancerOutcome disparitiesCpG sitesTumor progressionTumor tissueWhite womenGuanine dinucleotide sitesRacial disparitiesMortalityTumor epigenomeLinear regression models
2021
Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma.
Monsrud A, Avadhani V, Mosunjac M, Flowers L, Krishnamurti U. Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma. Archives Of Pathology & Laboratory Medicine 2021, 146: 1094-1101. PMID: 34936703, DOI: 10.5858/arpa.2021-0169-oa.Peer-Reviewed Original ResearchConceptsAnal squamous cell carcinomaPD-L1 expressionHIV viral loadTumor proportion scorePD-L1Squamous cell carcinomaOverall survivalCD4 countPrognostic factorsHIV statusViral loadCell carcinomaProportion scoreInvasive anal squamous cell carcinomaMedian cancer-specific survivalIndependent adverse prognostic factorDeath ligand 1 (PD-L1) expressionCancer-specific survivalAdverse prognostic factorLigand 1 expressionSignificant prognostic factorsDeath ligand 1Kaplan-Meier curvesWorse overall survivalLog-rank testHigh-Dynamic-Range Imaging in Photography of Cytopathology Slides: A Pilot Study
Roe C, Avadhani V, Mosunjac M, Tadros T, Oprea G, Krishnamurti U, Birdsong G. High-Dynamic-Range Imaging in Photography of Cytopathology Slides: A Pilot Study. Journal Of The American Society Of Cytopathology 2021, 10: s71. DOI: 10.1016/j.jasc.2021.07.121.Peer-Reviewed Original Research
2020
PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma
Monsrud A, Avadhani V, Mosunjac M, Krishnamurti U. PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma. American Journal Of Clinical Pathology 2020, 154: s67-s67. DOI: 10.1093/ajcp/aqaa161.146.Peer-Reviewed Original ResearchInvasive squamous cell carcinomaPD-L1 positivityPD-L1 expressionCases of ISCCSquamous cell carcinomaTumor proportion scoreSquamous intraepithelial lesionsPD-L1Normal mucosaIntraepithelial lesionsCell carcinomaGranular cytoplasmic stainingInvasive carcinomaProportion scoreLow-grade squamous intraepithelial lesionsCytoplasmic stainingPD-L1 positive casesAnal squamous intraepithelial lesionsHigh-grade intraepithelial lesionsGrade squamous intraepithelial lesionNuclear stainingAnal intraepithelial neoplasiaPD-L1 inhibitorsAberrant nuclear stainingAIN 2PD-L1 Expression is Associated with Poorer Survival in Anal Squamous Cell Carcinoma: Analysis from an Urban Public Hospital
Monsrud A, Avadhani V, Mosunjac M, Krishnamurti U. PD-L1 Expression is Associated with Poorer Survival in Anal Squamous Cell Carcinoma: Analysis from an Urban Public Hospital. American Journal Of Clinical Pathology 2020, 154: s66-s67. DOI: 10.1093/ajcp/aqaa161.145.Peer-Reviewed Original ResearchMedian cancer-specific survivalAnal squamous cell carcinomaPD-L1 expressionSquamous cell carcinomaCancer-specific survivalHIV viral loadPD-L1 positive statusPD-L1Cell carcinomaOverall survivalSpecific survivalHIV statusViral loadCD4 countPositive statusPD-L1 negative casesPD-L1 positive casesPD-L1 positive groupInvasive squamous cell carcinomaPositive PD-L1Cancer-specific deathSignificant prognostic factorsKaplan-Meier curvesWorse overall survivalLog-rank testHPV 16/18/45 Are Not The Most Frequent Genotypes In Women Of African-American Descent: Analysis In Cervical Pap Smears Of Women In An Inner-City Hospital
Dababneh M, Birdsong G, Mosunjac M, Krishnamurti U. HPV 16/18/45 Are Not The Most Frequent Genotypes In Women Of African-American Descent: Analysis In Cervical Pap Smears Of Women In An Inner-City Hospital. American Journal Of Clinical Pathology 2020, 154: s92-s92. DOI: 10.1093/ajcp/aqaa161.202.Peer-Reviewed Original ResearchHR-HPV positive rateHPV genotyping resultsInner-city hospitalHR-HPVHPV genotypesCervical cancerHPV 16HPV genotyping assaysSpecific HPV genotypesHigh-risk HPVCancer-related deathCervical Pap smearsHigh-risk genotypesAfrican AmericansGenotyping resultsAA descentHPV 16/18/45HPV 18/45African American descentPap smearCervical cytologyPositive rateGenotype 16Hispanic womenINTRODUCTION/HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer
Zhao J, Krishnamurti U, Zhang C, Meisel J, Wei Z, Suo A, Aneja R, Li Z, Li X. HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer. Pathology - Research And Practice 2020, 216: 153155. PMID: 32871536, DOI: 10.1016/j.prp.2020.153155.Peer-Reviewed Original ResearchConceptsHigh HER2/CEP17 ratioHER2/CEP17 ratioTumor responseBreast cancer casesNeoadjuvant HER2CEP17 ratioNeoadjuvant chemotherapyIHC 3Breast cancerCancer casesRCB II/IIIHER2-positive breast cancerHER2 IHC 3Complete pathologic responseResidual cancer burdenSmaller tumor sizePositive breast cancerLow nuclear gradeHER2 copy numberHigh Ki67Pathologic responseCancer burdenExcisional specimensPositive cancersTumor sizeProtein Conformational Changes in Breast Cancer Sera Using Infrared Spectroscopic Analysis
Ghimire H, Garlapati C, Janssen E, Krishnamurti U, Qin G, Aneja R, Perera A. Protein Conformational Changes in Breast Cancer Sera Using Infrared Spectroscopic Analysis. Cancers 2020, 12: 1708. PMID: 32605072, PMCID: PMC7407230, DOI: 10.3390/cancers12071708.Peer-Reviewed Original ResearchDo High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.
Kuhn T, Finneran C, Kohut A, Wang E, Birdsong G, Krishnamurti U, Mosunjac M, Tadros T, Oprea G, Avadhani V, Boguslawski S, Karlow S, Schnatz P, Khanna N, Flowers L. Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital. Journal Of Lower Genital Tract Disease 2020, 24: 353-357. PMID: 32569024, DOI: 10.1097/lgt.0000000000000556.Peer-Reviewed Original ResearchConceptsAGC Pap testsAbnormal uterine bleedingPap testUterine bleedingHPV positivityHuman papillomavirusLarge safety net hospitalBody mass indexHigh-risk lesionsLow-risk lesionsSafety-net hospitalLow socioeconomic statusBaseline characteristicsEndometrial biopsyMass indexSingle institutionMedical recordsNet hospitalHigh incidencePatientsLesionsSignificant associationHR lesionsBleedingLogistic regressionDetection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer
Maliniak M, Cheriyan A, Sherman M, Liu Y, Gogineni K, Liu J, He J, Krishnamurti U, Miller-Kleinhenz J, Ashiqueali R, He J, Yacoub R, McCullough L. Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer. Breast Cancer Research 2020, 22: 65. PMID: 32552729, PMCID: PMC7298873, DOI: 10.1186/s13058-020-01308-4.Peer-Reviewed Original ResearchConceptsBreast adipose tissueHazard ratioBreast cancerAdipose tissueMultivariable Cox proportional hazards modelsWhite womenCox proportional hazards modelProgression-free survivalMedical record reviewCurrent smoking statusConfidence intervalsProportional hazards modelBenign breast tissueBreast cancer prognosisNon-tumor tissuesCrown-like structuresMulti-racial populationEvidence of associationWorse OSWhite patientsClinical outcomesRecord reviewSmoking statusLifestyle factorsMultivariable modelObesity-associated methylation in breast tumors: a possible link to disparate outcomes?
Do W, Conneely K, Gabram-Mendola S, Krishnamurti U, D’Angelo O, Miller-Kleinhenz J, Gogineni K, Torres M, McCullough L. Obesity-associated methylation in breast tumors: a possible link to disparate outcomes? Breast Cancer Research And Treatment 2020, 181: 135-144. PMID: 32236829, DOI: 10.1007/s10549-020-05605-6.Peer-Reviewed Original ResearchConceptsCause mortalityER statusMultivariable Cox proportional hazards modelsCox proportional hazards modelBreast cancer tumor tissuesBreast cancer outcomesBreast cancer incidenceEstrogen receptor statusBody mass indexPrimary risk factorNon-Hispanic blacksCancer tumor tissuesReceptor statusMass indexCancer outcomesCpG sitesRisk factorsCancer incidenceBreast cancerHazards modelBreast tumorsTumor tissueWhite womenObesityRace disparities