2023
An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy
Mudrinich S, Nguyen M, Blemur D, Wang X, Wang Y, Krishnamurti U, Mosunjac M, Flowers L. An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. Journal Of Lower Genital Tract Disease 2023, 28: 101-106. PMID: 38117565, DOI: 10.1097/lgt.0000000000000773.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirus (hrHPV) testingLow CD4 countRisk factorsTriage toolAnal cytologyCD4 countTransgender womenAdult cisgender menHigh-Resolution AnoscopyHuman papillomavirus testingCisgender menPredictive risk factorsRetrospective cohort studySignificant risk factorsSociodemographic risk factorsNegative predictive valueNovel triage toolHrHPV positivityUnderwent cytologyHrHPV testingCohort studyAnal neoplasiaScreening patternsPredictive valueHIV
2021
Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma.
Monsrud A, Avadhani V, Mosunjac M, Flowers L, Krishnamurti U. Programmed Death Ligand-1 Expression Is Associated With Poorer Survival in Anal Squamous Cell Carcinoma. Archives Of Pathology & Laboratory Medicine 2021, 146: 1094-1101. PMID: 34936703, DOI: 10.5858/arpa.2021-0169-oa.Peer-Reviewed Original ResearchConceptsAnal squamous cell carcinomaPD-L1 expressionHIV viral loadTumor proportion scorePD-L1Squamous cell carcinomaOverall survivalCD4 countPrognostic factorsHIV statusViral loadCell carcinomaProportion scoreInvasive anal squamous cell carcinomaMedian cancer-specific survivalIndependent adverse prognostic factorDeath ligand 1 (PD-L1) expressionCancer-specific survivalAdverse prognostic factorLigand 1 expressionSignificant prognostic factorsDeath ligand 1Kaplan-Meier curvesWorse overall survivalLog-rank test
2020
Diagnosing Anal Squamous Intraepithelial Lesions With and Without p16: An Interobserver Variability Study.
Krishnamurti U, Mohammad M, Monsrud A, Mosunjac M, Oprea G, Hanley K, Tadros T, Flowers L, Mosunjac M. Diagnosing Anal Squamous Intraepithelial Lesions With and Without p16: An Interobserver Variability Study. Journal Of Lower Genital Tract Disease 2020, 24: 69-74. PMID: 31860579, DOI: 10.1097/lgt.0000000000000500.Peer-Reviewed Original Research
2017
Hormone Receptor-Positive Breast Cancer Has a Worse Prognosis in Male Than in Female Patients
Li X, Yang J, Krishnamurti U, Huo L, Ward K, O'Regan R, Peng L. Hormone Receptor-Positive Breast Cancer Has a Worse Prognosis in Male Than in Female Patients. Clinical Breast Cancer 2017, 17: 356-366. PMID: 28576631, DOI: 10.1016/j.clbc.2017.03.005.Peer-Reviewed Original ResearchConceptsMale breast carcinomaFemale breast carcinomaHormone receptorsMBC patientsWorse OSOverall survivalBreast carcinomaBreast cancerStage IHormone receptor-positive breast cancerEarly-stage hormone receptorReceptor-positive breast cancerNational Cancer Institute's SurveillanceEnd Results (SEER) databaseWorse overall survivalBreast carcinoma casesSimilar survival ratesMBC subtypesWorse survivalClinicopathologic featuresOverall incidenceResults databaseWorse prognosisHER2 statusFBC patientsPathobiology of human papillomaviruses in human immunodeficiency virus – Infected persons
Krishnamurti U, Unger E. Pathobiology of human papillomaviruses in human immunodeficiency virus – Infected persons. Seminars In Diagnostic Pathology 2017, 34: 364-370. PMID: 28549522, DOI: 10.1053/j.semdp.2017.04.005.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAcquired Immunodeficiency SyndromeHuman papillomavirusHuman immunodeficiency virus-infected personsCareful epidemiologic studiesMultiple HPV typesVirus-infected personsNegative patientsHPV typesImmunodeficiency syndromeCervical cancerImmunodeficiency virusPrimary preventionViral etiologyHIV epidemicEpidemiologic studiesSurveillance indicatorsLaboratory measuresPapillomavirusDiseasePathobiologyVirus groupDefinitive identificationPatientsHigh frequency
2007
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Krishnamurti U, Sasatomi E, Swalsky P, Finkelstein S, Ohori N. Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations? Archives Of Pathology & Laboratory Medicine 2007, 131: 74-80. PMID: 17227126, DOI: 10.5858/2007-131-74-aolohi.Peer-Reviewed Original ResearchConceptsK-ras mutationsBile duct brushingsLoss of heterozygosityMalignant outcomeFractional allelic lossDuct brushingsCytology casesAllelic lossMolecular alterationsBile duct brushing cytologyPilot studyConventional cytologic evaluationSurgical pathology specimenCorresponding surgical specimensDuct brushing cytologySurgical pathology specimensDetection of malignancySubtle molecular alterationsSurgical outcomesSurgical specimenPathology specimenCytologic findingsSurgical specimensBrushing cytologyCytologic evaluation