Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities
Gohar J, Do W, Miller-Kleinhenz J, Conneely K, Krishnamurti U, D’Angelo O, Gogineni K, Torres M, Gabram-Mendola S, McCullough L. Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast Cancer Research And Treatment 2022, 191: 653-663. PMID: 34978015, DOI: 10.1007/s10549-021-06430-1.Peer-Reviewed Original ResearchConceptsNeighborhood-level factorsCause mortalityMultivariable Cox proportional hazards modelsCox proportional hazards modelCancer outcome disparitiesBreast cancer outcomesTumor methylationProportional hazards modelNon-Hispanic blacksArea-level factorsCancer outcomesFalse discovery rate thresholdBody of evidenceCancer disparitiesBreast cancerOutcome disparitiesCpG sitesTumor progressionTumor tissueWhite womenGuanine dinucleotide sitesRacial disparitiesMortalityTumor epigenomeLinear regression models