2023
Influence of birth weight on later life cardiovascular structure, function and disease: unpacking influences from direct genetic effects versus intrauterine programming
Ardissino M, Slob E, Rayes B, Morley A, Raisi-Estabragh Z, De Marvao A, Williamson C, Rogne T, Burgess S, Ng F. Influence of birth weight on later life cardiovascular structure, function and disease: unpacking influences from direct genetic effects versus intrauterine programming. European Heart Journal 2023, 44: ehad655.2377. DOI: 10.1093/eurheartj/ehad655.2377.Peer-Reviewed Original ResearchCoronary artery diseaseFetal genetic effectsLow ejection fractionSystolic blood pressureBody mass indexBirth weightArtery diseaseAtrial fibrillationCardiovascular diseaseHigh riskMendelian randomisationEjection fractionBlood pressureMass indexRisk factorsGestational age-adjusted birth weightCardiac structureAge-adjusted birth weightHigher systolic blood pressureLater-life cardiovascular diseaseCardinal risk factorCardiometabolic risk factorsHigh birth weightLife cardiovascular diseaseBody surface areaBirth weight influences cardiac structure, function, and disease risk: evidence of a causal association
Ardissino M, Morley A, Slob E, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg M, Ng F. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. European Heart Journal 2023, 45: 443-454. PMID: 37738114, PMCID: PMC10849320, DOI: 10.1093/eurheartj/ehad631.Peer-Reviewed Original ResearchLow birth weightAdverse intrauterine environmentCoronary artery diseaseBirth weightIntrauterine environmentCardiac structureArtery diseaseFoetal effectsCardiovascular disease prevention strategiesDisease riskAdverse cardiac structureCardiovascular disease riskCommon pregnancy complicationLower stroke volumeDisease prevention strategiesMendelian randomization studyBenjamini-Hochberg correctionPregnancy complicationsIschemic strokeHeart failureAtrial fibrillationCardiometabolic diseasesIntrauterine influencesStroke volumeCardiovascular diseaseSex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study
Ardissino M, Slob E, Carter P, Rogne T, Girling J, Burgess S, Ng F. Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study. Journal Of The American Heart Association 2023, 12: e027933. PMID: 36846989, PMCID: PMC10111460, DOI: 10.1161/jaha.122.027933.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseBody mass indexHeart failureCardiovascular diseaseReproductive factorsArtery diseaseIschemic strokeMass indexAtrial fibrillationLive birthsFirst birthCardiovascular disease riskType 2 diabetesBackground Observational studiesMendelian randomizationMendelian randomization studyModifiable mediatorsBlood pressureResidual confoundingObservational studyPrimary analysisRandomization studyDisease riskStrokeClinical interventions
2022
Impact of reproductive factors on major cardiovascular disease risk in women: a Mendelian randomization study
Ardissino M, Slob E, Rogne T, Burgess S, Ng F. Impact of reproductive factors on major cardiovascular disease risk in women: a Mendelian randomization study. European Heart Journal 2022, 43: ehac544.2500. DOI: 10.1093/eurheartj/ehac544.2500.Peer-Reviewed Original ResearchCoronary artery diseaseCardiovascular diseaseArtery diseaseHeart failureLive birthsIschemic strokeAtrial fibrillationRisk factorsFirst birthObservational studyReproductive factorsEarly menarcheReproductive historyFemale-specific risk factorsMajor cardiovascular disease riskSex-specific risk factorsBackground Cardiovascular diseaseCardiovascular disease riskMultiple observational studiesPrimary prevention measuresMendelian randomization studyEarly ageCardiovascular morbidityCardiovascular riskResidual confounding