2006
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet
Bailey M, Cantone A, Yan Q, MacGregor G, Leng Q, Amorim J, Wang T, Hebert S, Giebisch G, Malnic G. Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. Kidney International 2006, 70: 51-59. PMID: 16710355, DOI: 10.1038/sj.ki.5000388.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBartter SyndromeBiological TransportDietDisease Models, AnimalHypokalemiaKidney Tubules, DistalLarge-Conductance Calcium-Activated Potassium ChannelsLoop of HenleMiceMice, Mutant StrainsPeptidesPotassiumPotassium Channels, Inwardly RectifyingPotassium, DietaryConceptsCortical collecting ductLate distal tubuleType II Bartter syndromeRenal potassium wastingMaxi-K channelsPotassium secretionDistal tubulesBartter's syndromePotassium wastingPotassium excretionIberiotoxin (IBTX)-sensitiveRenal potassium lossSalt-wasting disorderUrinary potassium excretionWild-type miceRenal potassium excretionFree-flow micropunctureDistal convoluted tubuleIncreased renal potassium excretionHigh-K dietLoop of HenleROMK-deficientPersistent hypokalemiaROMK channelsMaxi-K
2003
Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle
Wang T, Sterling H, Shao W, Yan Q, Bailey M, Giebisch G, Wang W. Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle. American Journal Of Physiology. Renal Physiology 2003, 285: f484-f490. PMID: 12890663, DOI: 10.1152/ajprenal.00135.2003.Peer-Reviewed Original ResearchConceptsLoop of HenleHigh K+K+ channelsApical 70-pS K+ channelRegulation of Na+ transportNa+ transportFluid absorptionApical K+ channelsIn vivo microperfusionInhibition of HORenal sodium excretionGlomerular filtration rateHO-2 expressionInhibitor of HORenal clearance studiesHK ratsHO-2K+ recyclingNa+ absorptionUrinary Na+Sodium excretionChromium mesoporphyrinRat chowWestern blot analysisFiltration rate