2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2020
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Developmental Cell 2020, 55: 328-340.e5. PMID: 33091369, PMCID: PMC7658051, DOI: 10.1016/j.devcel.2020.09.013.Peer-Reviewed Original ResearchConceptsFate specificationPreimplantation developmentKinase translocation reporterMammalian preimplantation embryosInner cell massEmbryonic stem cellsSingle cellsDifferent cell typesMulticellular organismsEndogenous taggingDaughter cellsNanog proteinActive ERKNanog levelsERK activityGene expressionPreimplantation embryosCell cycleTrophectoderm cellsERK inhibitionCell typesStem cellsLive embryosCell massEmbryos