2024
Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder AdultsUS adultsAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseApplying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age — China and the US, 2020–2021
Huo S, Feng D, Gill T, Chen X. Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age — China and the US, 2020–2021. China CDC Weekly 2024, 6: 213-218. PMID: 38532746, PMCID: PMC10961215, DOI: 10.46234/ccdcw2024.043.Peer-Reviewed Original ResearchSelf-rated healthSenior healthChildhood circumstancesPromote health equityEarly-life interventionsHealth equityChina HealthChildhood healthRetirement StudyHealthSelf-ratingsAging populationFinancial statusChinese participantsAge ChinaConditional inference treesChildhoodOut-of-sample mean squared errorsInterventionParticipantsRegional differencesUSStatusInference treesRetirement
2023
A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways
Ye Y, Noche R, Szejko N, Both C, Acosta J, Leasure A, Brown S, Sheth K, Gill T, Zhao H, Falcone G. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. GeroScience 2023, 45: 2511-2523. PMID: 36928559, PMCID: PMC10651618, DOI: 10.1007/s11357-023-00771-z.Peer-Reviewed Original ResearchConceptsFried frailty scoreBiology of frailtyEuropean descent participantsOccurrence of frailtyGenome-wide association studiesMendelian randomization analysisFrailty scoreChronic painJoint disordersPolygenic risk scoresRespiratory diseaseInflammation pathwaysRisk scoreClinical phenotypeBrain tissueCausal associationFrailtyAge-related pathwaysRandomization analysisGenetic factorsAssociation studiesUK BiobankRetirement StudyPerson's vulnerabilitySignificant genetic correlations
2019
ASSOCIATIONS OF GENETICS AND LIFE COURSE CIRCUMSTANCES WITH A NOVEL AGING MEASURE THAT CAPTURES MORTALITY RISK
Liu Z, Chen X, Gill T, Ma C, Crimmins E, Levine M. ASSOCIATIONS OF GENETICS AND LIFE COURSE CIRCUMSTANCES WITH A NOVEL AGING MEASURE THAT CAPTURES MORTALITY RISK. Innovation In Aging 2019, 3: s322-s323. PMCID: PMC6840282, DOI: 10.1093/geroni/igz038.1177.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseSocioeconomic statusAdulthood socioeconomic statusU.S. older adultsChildhood socioeconomic statusMorbidity riskAdulthood circumstancesMortality riskPhenotypic AgeAdulthood adversityGenetic predispositionSocioenvironmental circumstancesChildhood adversityOlder adultsDisadvantaged subpopulationsGenetic riskU.S. populationPhenotypic agingSizable proportionDisadvantaged circumstancesPhenoAgeRetirement StudyU.S. HealthDisease