2024
A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts
Johnson B, Iuliano M, Lam T, Biederer T, De Camilli P. A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts. Journal Of Cell Biology 2024, 223: e202311137. PMID: 39158698, PMCID: PMC11334333, DOI: 10.1083/jcb.202311137.Peer-Reviewed Original ResearchConceptsPlasma membraneNon-vesicular lipid transferSites of cell contactC-terminus motifsCell contact-dependent signalsContact-dependent signalingCell-cell contactER/PM junctionsTMEM24ER proteinsPM proteinsSynCAM 1Cell adhesion moleculesCellular functionsLipid transferC2CD2Phospholipid transportLipid transportCell contactProteinAdhesion moleculesCalcium homeostasisCellsFamily membersParalogs
2023
Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
de Arce K, Ribic A, Chowdhury D, Watters K, Thompson G, Sanganahalli B, Lippard E, Rohlmann A, Strittmatter S, Missler M, Hyder F, Biederer T. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Nature Communications 2023, 14: 459. PMID: 36709330, PMCID: PMC9884278, DOI: 10.1038/s41467-023-36042-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion Molecule-1CognitionMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsPrefrontal CortexSynapsesConceptsPrefrontal cortexDKO miceSynCAM 1Aberrant neuronal activityDendritic spine numberPrefrontal cortex synapsesSynapse organizersSynapse numberMature brainNeuronal activityKnockout miceSpine numberSynapse developmentCognitive functionTrans-synaptic complexesImmunoglobulin family membersMiceFamily membersSynapsesLRRTM1Behavioral domainsHippocampusCognitive tasksConcerted roleCortex
2010
SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones
Stagi M, Fogel AI, Biederer T. SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 7568-7573. PMID: 20368431, PMCID: PMC2867738, DOI: 10.1073/pnas.0911798107.Peer-Reviewed Original Research
2007
Mixed-culture assays for analyzing neuronal synapse formation
Biederer T, Scheiffele P. Mixed-culture assays for analyzing neuronal synapse formation. Nature Protocols 2007, 2: 670-676. PMID: 17406629, DOI: 10.1038/nprot.2007.92.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Culture TechniquesIntercellular Signaling Peptides and ProteinsMembrane ProteinsNeuronsProteomicsSynapsesConceptsVertebrate central nervous systemIndividual cell surface proteinsSynaptic adhesion complexesCell biological mechanismsPostsynaptic membrane domainsCell surface proteinsAssembly of synapsesAdhesion complexesMembrane domainsNeuronal synapse formationIndividual proteinsSynaptogenic activityGenetic studiesBidirectional signalingPrimary neuronal culturesSynapse formationSynaptic differentiationMixed culture assayBiological mechanismsSynaptic structureProteinNew insightsSynaptic cleftNeuronal culturesAssay system
2001
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins*
Biederer T, Südhof T. CASK and Protein 4.1 Support F-actin Nucleation on Neurexins*. Journal Of Biological Chemistry 2001, 276: 47869-47876. PMID: 11604393, DOI: 10.1074/jbc.m105287200.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid SequenceAnimalsBinding SitesCalcium-Calmodulin-Dependent Protein KinasesCytoplasmCytoskeletal ProteinsGlycophorinsGuanylate KinasesMembrane ProteinsMolecular Sequence DataNerve Tissue ProteinsNeuropeptidesNucleoside-Phosphate KinaseProtein BindingRatsSequence Homology, Amino AcidSpectrinConceptsProtein 4.1Actin cytoskeletonActin filamentsBrain-enriched isoformF-actin nucleationCytosolic C-terminusClass of proteinsCell surface proteinsCytosolic tailPDZ domainAdaptor proteinCellular processesMembrane organizationC-terminusNeurexinsProtein p55Glycophorin CCell surfaceRat brain extractsIntercellular junctionsSpectrin filamentsErythrocyte isoformsCytoskeletonProteinLocomotion of cells