2023
Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
de Arce K, Ribic A, Chowdhury D, Watters K, Thompson G, Sanganahalli B, Lippard E, Rohlmann A, Strittmatter S, Missler M, Hyder F, Biederer T. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Nature Communications 2023, 14: 459. PMID: 36709330, PMCID: PMC9884278, DOI: 10.1038/s41467-023-36042-w.Peer-Reviewed Original ResearchConceptsPrefrontal cortexDKO miceSynCAM 1Aberrant neuronal activityDendritic spine numberPrefrontal cortex synapsesSynapse organizersSynapse numberMature brainNeuronal activityKnockout miceSpine numberSynapse developmentCognitive functionTrans-synaptic complexesImmunoglobulin family membersMiceFamily membersSynapsesLRRTM1Behavioral domainsHippocampusCognitive tasksConcerted roleCortex
2014
Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1
Ribic A, Liu X, Crair MC, Biederer T. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology 2014, 522: 900-920. PMID: 23982969, PMCID: PMC3947154, DOI: 10.1002/cne.23452.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnalysis of VarianceAnimalsAnimals, NewbornCell Adhesion Molecule-1Cell Adhesion MoleculesCo-Repressor ProteinsDNA-Binding ProteinsElectroretinographyFemaleGene Expression Regulation, DevelopmentalImmunoglobulinsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronNerve Tissue ProteinsPhosphoproteinsReceptors, Metabotropic GlutamateRetinaRetinal Rod Photoreceptor CellsSynapsesVesicular Glutamate Transport Protein 1ConceptsCell adhesion molecule-1Adhesion molecule-1Ribbon synapsesKO retinasSynaptic cell adhesion molecule 1Molecule-1Mouse photoreceptor ribbon synapsesInner retinal layersPhotoreceptor ribbon synapsesRod visual pathwayEarly postnatal stagesPlexiform layerKO micePhotoreceptor synapsesSynaptic organizationExcitatory synapsesQuantitative ultrastructural analysisRetinal layersKnockout miceOuter nuclearVisual pathwaySynapse developmentElectroretinogram recordingsPostnatal stagesAdhesion molecules
2012
The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization
Cheadle L, Biederer T. The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. Journal Of Cell Biology 2012, 199: 985-1001. PMID: 23209303, PMCID: PMC3518221, DOI: 10.1083/jcb.201205041.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell Adhesion Molecule-1Cell Adhesion MoleculesCytoskeletal ProteinsCytoskeletonDendritic SpinesGuanine Nucleotide Exchange FactorsHEK293 CellsHippocampusHumansImmunoglobulinsMiceMice, KnockoutNeurogenesisNeuronsNeuropeptidesProtein BindingProtein Structure, TertiaryProteomicsRac GTP-Binding ProteinsRac1 GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsSignal TransductionSynapsesConceptsSynCAM 1Synapse developmentF-actin assemblyCytoskeletal dynamicsGTPase Rac1Retrograde signalsSynaptic adhesionFARP1Transsynaptic interactionsFilopodial dynamicsProtein 1Synapse formationSynaptic complexImmature neuronsSpine densitySpine morphologySynapse numberPathwayKnockout miceSynaptic membranesPleckstrinFERMRac1The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior
Giza JI, Jung Y, Jeffrey RA, Neugebauer NM, Picciotto MR, Biederer T. The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior. Neuropsychopharmacology 2012, 38: 628-638. PMID: 23169347, PMCID: PMC3572459, DOI: 10.1038/npp.2012.226.Peer-Reviewed Original ResearchConceptsNucleus accumbensDrugs of abuseSynCAM 1Cocaine effectsSynapse structureMushroom-type spinesExcitatory synapse numberMedium spiny neuronsAddiction-related behaviorsKO miceSpiny neuronsStubby spinesSynapse numberAdhesion molecule proteinsExcitatory synapsesCocaine administrationTrans-synaptic interactionsKnockout micePsychostimulant effectsNAc synapsesStructural remodelingTherapeutic interventionsSynaptic cleftPsychostimulant cocaineSynapse developmentSpecific N‐glycans on SynCAM Ig proteins regulate synaptic adhesion and synapse development
Biederer T. Specific N‐glycans on SynCAM Ig proteins regulate synaptic adhesion and synapse development. The FASEB Journal 2012, 26: 232.2-232.2. DOI: 10.1096/fasebj.26.1_supplement.232.2.Peer-Reviewed Original ResearchTrans-synaptic interactionsSynapse developmentN-glycansSite-specific N-glycosylationSpecialized cell junctionsSpecific N-glycansProtein complexesFirst Ig domainN-glycosylationBinding interfaceSynaptic adhesionIg domainsFunctional analysisSynCAM 1Cell junctionsIg1 domainImmunoglobulin proteinNovel mechanismIg proteinGlycosylationProteinAdhesive interactionsSynCAMSynaptic cleftExcitatory synapses
2011
Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation
Fogel AI, Stagi M, Perez de Arce K, Biederer T. Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation. The EMBO Journal 2011, 30: 4728-4738. PMID: 21926970, PMCID: PMC3243608, DOI: 10.1038/emboj.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion Molecule-1Cell Adhesion MoleculesCell Adhesion Molecules, NeuronalCell DifferentiationCells, CulturedChlorocebus aethiopsCoculture TechniquesCOS CellsFluorescence Resonance Energy TransferHEK293 CellsHippocampusHumansImmunoglobulinsImmunohistochemistryMiceNeuritesProtein Structure, QuaternarySynapsesConceptsSynCAM 1Specialized adhesion sitesSynapse formationTrans-synaptic interactionsSynaptic cleftCI assemblyProtein complexesSynaptic cell adhesion molecule SynCAM 1Adhesion sitesSynaptogenic activityAdhesive functionSynapse developmentStructural organizationNovel insightsSynapse inductionLateral assemblyAdhesive capacityAdhesion moleculesSynaptic morphologyAdhesive mechanismsOligomerizationAssemblyAxo-dendritic contactsCleftLater stages
2010
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
Robbins EM, Krupp AJ, de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V, Biederer T. SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning. Neuron 2010, 68: 894-906. PMID: 21145003, PMCID: PMC3026433, DOI: 10.1016/j.neuron.2010.11.003.Peer-Reviewed Original ResearchConceptsSynapse numberSynCAM 1Excitatory synapse numberLong-term depressionActivity-dependent changesTransgenic brainsExcitatory synapsesMature synapsesTransgenic miceNeuronal connectivityNeuronal circuitsSynapse developmentSpatial learningAdhesion moleculesNeuronal networksSynapsesAdult networksMiceBrainOverexpressionPlasticityExpressionSynaptogenesis
2007
SynCAMs Organize Synapses through Heterophilic Adhesion
Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T. SynCAMs Organize Synapses through Heterophilic Adhesion. Journal Of Neuroscience 2007, 27: 12516-12530. PMID: 18003830, PMCID: PMC6673342, DOI: 10.1523/jneurosci.2739-07.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCell Adhesion Molecules, NeuronalCell DifferentiationCell LineCells, CulturedCoculture TechniquesHippocampusHumansImmunoglobulinsMacromolecular SubstancesMiceNeural PathwaysPresynaptic TerminalsProtein IsoformsRatsRats, Sprague-DawleySynapsesSynaptic MembranesSynaptic TransmissionTumor Suppressor ProteinsConceptsAdhesion complexesDivergent expression profilesImmunoglobulin superfamily memberHeterophilic complexesProtein familyPosttranslational modificationsHeterophilic adhesionSuperfamily membersCell adhesion moleculeSynapse organizationExpression profilesSynapse developmentSynCAM 1Cell junctionsActive presynaptic terminalsPostsynaptic sideMolecular compositionAdhesion moleculesAdhesive patternsProteinSynaptic cleftPresynaptic terminalsComplexesExcitatory neurotransmissionFunctional synapses