A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking
McKee SA, Verplaetse TL. A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking. Drug And Alcohol Dependence Reports 2022, 4: 100085. PMID: 36120181, PMCID: PMC9481061, DOI: 10.1016/j.dadr.2022.100085.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol self-administration paradigmSelf-administration paradigmHeavy drinkingAlcohol consumptionMore alcoholAd libitum alcohol consumptionBlood alcohol levelsCross-over designPercent of participantsPreferred alcoholic beverageSelf-administration modelAlcoholic beveragesMedication screeningMedication signalsUse disordersAlcohol levelsGreater cravingFirst drinkDrinkingStress imageryParticipantsUsing machine learning to predict heavy drinking during outpatient alcohol treatment
Roberts W, Zhao Y, Verplaetse T, Moore KE, Peltier MR, Burke C, Zakiniaeiz Y, McKee S. Using machine learning to predict heavy drinking during outpatient alcohol treatment. Alcohol Clinical And Experimental Research 2022, 46: 657-666. PMID: 35420710, PMCID: PMC9180421, DOI: 10.1111/acer.14802.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeavy drinkingTreatment outcomesInvasive assessment methodsOutpatient AUD treatmentLast monthOutpatient alcohol treatmentMultisite clinical trialAccurate clinical predictionsHeavy alcohol useSex differencesBi-weekly sessionsAlcohol treatment outcomesPatient characteristicsClinical outcomesClinical trialsClinical dataStratified analysisEffective treatmentPsychiatric disordersUse disordersAUD treatmentSubstantial sex differencesAlcohol treatmentFirst month