2023
Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors
Slotkin R, Kyriakides T, Kundu A, Stack G, Sutton R, Gupta S. Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors. PLOS ONE 2023, 18: e0289713. PMID: 37643190, PMCID: PMC10464955, DOI: 10.1371/journal.pone.0289713.Peer-Reviewed Original ResearchBaseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial
Robertson D, Dominitz J, Beed A, Boardman K, Del Curto B, Guarino P, Imperiale T, LaCasse A, Larson M, Gupta S, Lieberman D, Planeta B, Shaukat A, Sultan S, Menees S, Saini S, Schoenfeld P, Goebel S, von Rosenvinge E, Baffy G, Halasz I, Pedrosa M, Kahng L, Cassim R, Greer K, Kinnard M, Bhatt D, Dunbar K, Harford W, Mengshol J, Olson J, Patel S, Antaki F, Fisher D, Sullivan B, Lenza C, Prajapati D, Wong H, Beyth R, Lieb J, Manlolo J, Ona F, Cole R, Khalaf N, Kahi C, Kohli D, Rai T, Sharma P, Anastasiou J, Hagedorn C, Fernando R, Jackson C, Jamal M, Lee R, Merchant F, May F, Pisegna J, Omer E, Parajuli D, Said A, Nguyen T, Tombazzi C, Feldman P, Jacob L, Koppelman R, Lehenbauer K, Desai D, Madhoun M, Tierney W, Ho M, Hockman H, Lopez C, Carter Paulson E, Tobi M, Pinillos H, Young M, Ho N, Mascarenhas R, Promrat K, Mutha P, Pandak W, Shah T, Schubert M, Pancotto F, Gawron A, Underwood A, Ho S, Magno-Pagatzaurtundua P, Toro D, Beymer C, Kaz A, Elwing J, Gill J, Goldsmith S, Yao M, Protiva P, Pohl H, Kyriakides T, Kleiner E, Sullivan K, O'Leary J, Chiu W, Huang H, Russo J, Johnson G, Antonelli P, Burns A, Peduzzi P, Ciarleglio M, O'Connor T, Wallace R, Williams A, Tommessilli L, Taylor S, Pitts S, Mancini L, O'Brien P, O'Neil S, Perry M, McBride V, Carr W, Joncas C, O'Donnell E, Sather M, Warren S, Conner T, Honstein E, Sutton T, Putnam T, Branham K, Argyres D, Peterson D, Kennedy A, Carrick T, Apodaca C, Eden G, Martinez T, Tripp C, Nicholson M, Schwartz A, Felix M, Ward A, Marquez L, Lovato K, Cochran N, Tapia S, VanRaden M, Badgett C, Taylor Z, Pontzer J, Dorman B, Chavez M, Georg S, Templton T, Calais L, Haakensen C, Curtis B, Prehoda M, Colling C, Older D, Apodaca G, Sova J, Klee M, Wolfram-Aduan A, Ulatowski M, Hamilton B, Bopp (Formerly England) K, Ford G, Lace N, McDonnell W, Piehl G, Patel-Ejarque N, Berry M, Strubeck E, Chesnut L, Burridge L, Bean J, Kowal L, Voorhees (Formerly Rose) A, Ridley A, Croteau H, Bessett K, Fletcher C, Barbaresso M, Drummond A, Belanger K, McRobert E, Myers A, Trumble E, Rose P, Biswas A, Enache E, Shankin M, Strunk D, Simpson A, Harrison M, Prasad M, Robinson P, Flores A, Jananeh S, Tanukonda S, Ahmadi-Izadi G, Madihi S, Raufman J, Grady D, Britton A, Goldstein C, Thomas M, Lee V, Belizaire M, Costa C, Davis S, Decker M, Marrama A, Gilroy-Fanaras D, Gass J, Reece S, Tobin D, Carroll R, Ferreira M, Irvin D, Morken V, Covelli M, Medina T, Schiebel F, Shreves A, Shriver D, Frederick Y, Postle (formerly Matheny) C, Shaw J, Pastor D, Armstrong A, Kumaran V, Pinto A, Marshall V, McLarty S, Carlton J, Murphy K, McLemore K, Mortensen E, LePage J, Willis C, Berman K, Dunn T, Espinoza J, Schleski E, Shrader S, Gropp K, Kanaan Z, Miller L, Anees M, Judd S, Berchou V, Balogh D, Jones E, Covert K, Davis Y, Marbury C, Rambus M, Olgren E, Gellad Z, Sullivan B, Day T, Teehan S, Peters L, Hernandez-Chavez R, Murphy E, Cherry J, Graham E, Johnson J, Wooten W, Trujillo J, Harris M, Alizadeh M, Lo M, Sultan S, Brown L, Koster L, LeLaurin J, Irwin A, Kay N, Mckillip S, Lowe M, Yeralan S, Leehey D, McBurney C, Jain A, Park T, Broadwater L, El-Serag H, Shaib Y, Taylor E, Nair P, Broussard E, Gibson E, Hawkins R, Natividad T, Courtade D, Palmer M, Martinez S, Panagiotis K, Morrow C, Ballard C, Barker B, Garner M, McCalley S, Schwartzkopf A, Wright A, Titi M, Higbee A, Pratiksha S, Jones A, Shipe T, McKee J, Vennalaganti R, Terrey K, Maruf L, Brown D, Crouse E, Marchant-Miros K, Ussery B, Ducker L, Estell J, Porchia S, Kim M, Kim C, Chan B, Hayton A, Christiansen H, Peterson M, Ding G, Simpson V, Read S, Mamani G, Salazar J, Kato J, Bowie M, Carnevale R, Halim M, Sahagian A, Ibarra A, Travis Z, Garcia J, Gill A, Starzyk J, Sumarli S, Johnson V, Peresuh S, Quimby T, Cordova R, Herold L, Hawley A, Goo T, Kidao J, Lee R, Freidel C, Gutierrez E, Noorisharghi N, Ivie G, Jawish T, Partin S, Yoo G, Fabilane C, Noori N, Lang E, Senen S, Partin S, Fathi M, Chauvin R, Feiger J, Reataza M, Morgan T, Asghar A, Jacobs J, Kashefi M, May F, Ohning G, Padua D, Smutko V, Oh D, Kosoyan H, Dreskin B, Luu K, Alas A, Bharath P, Dixit V, Sanford** D, Vu J, Kadi S, Nwajuaku T, Smith J, Kincaid J, Mir M, Lanceta J, Rice J, Agarwal P, Augustine A, Prickel H, Vue J, Guerrero K, Levenson S, Aguilera-Fish A, Chestnut L, Jobse B, Lombardo C, Silver T, Ahmed N, Bockhold K, Koppelman R, Carneiro F, Garcia-Morales R, Spector D, Gomez J, Lehenbauer K, Reinink A, Anway R, Evans-Lindquist M, Eggers T, Green M, Pretti A, Meyeraan T, Condon D, Cavanagh M, DeFalco C, Cutting J, Joseph K, Dean S, Mitchell S, Phillips V, Krueger C, Zink D, Goldberg K, Patel N, Martinez Gonzalez M, Davis-Underwood H, O'Sullivan A, Suppes T, Bratcher K, Stern D, Wu R, Damisa J, Warsi R, Nguyen T, Pinillos H, Flowers E, Kuramoto A, Thurmond C, Orozco L, Farrell G, Jaynes R, Saenz P, Perez C, Collins J, Lin E, Onstad L, Pitts A, Osborn K, Kenworthy-Heinige T, Casey A, Gold D, Olivo C, Joos S, Subramanian S, Forro V, Cannady A, Usih J, Raitt M, Flynn M, Shittu Y, Jawaid M, Anderson R, Poole D, Butler C, Snead L, Christine H, Swanson G, Heumann D, Pandak W, Spataro J, Bajaj J, Solomon C, Smith Gilles H, Zafass A, Tilak S, Fuchs M, Davis M, Blackman L, Lemler J, Munsey R, Deebo J, McCarthy J, Noel M, Hurley R, Zurowski W, Sharpe A, Wilson K, Peets R, Lorenso B, Burrison S, Johnson D, Angelovic A, Erickson N, Hanson H, Bailey T, Genung K, Dulin H, Neuharth R, Clegg D, Velarde K, Dever J, Murphy M, Beck D, Wasil M, Vazquez J, O'Neil E, Ganji G, Ducom J, Lee M, Hovespians R, Margolis J, Simmons B, Sweeney (formerly St. Martin) J, Henry R, Martin-Ortiz J, Santiago-Rivera L, Gonzalez - Aviles G, Pedrosa C, Bird-Caceres J, Padilla B, Baez-Corujo F, Martinez- Ortiz Y, Vazquez E, Grigg-Gutierrez N, Laboy-Olivieri C, Urbina-Velez R, Andrews S, Rosa-Cruz S, Tirado-Montijo R, Otero-Aponte K, Martinez-Martino M, Freire A, Soto-Ramos A, Santana-Perez M, Araujo J, Vanderwarker C, Alexander J, Nevins E, LaGuire J, Guerrero L, Piehl G, Jenkins M, Chen T, Jang J, Tanus A, McKelvy P, Sayuk G, Chandiramani P, Vargo (Formerly Shoults) L, Vargo K, Lawrence S, Blythe K, Goldsmith S, Campbell R, Craddock M, Amodeo D, Reinhard R, Durant B, Wells B, Zoble A, Papademetriou M, Roche N, Adler P, Krishna A, Glaze D, Wijegunawardana D, Yeroushalmi S, Laine L, Mautner R, Bugaj J, Anderson J, Croteau H, Kingman L, Burridge L. Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial. JAMA Network Open 2023, 6: e2321730. PMID: 37432690, PMCID: PMC10336619, DOI: 10.1001/jamanetworkopen.2023.21730.Peer-Reviewed Original ResearchConceptsFecal immunochemical testImmunochemical testEligible individualsAnnual fecal immunochemical testColorectal Cancer Screening TrialScreening testVeterans Affairs Medical CenterAverage CRC riskCancer Screening TrialCancer mortality outcomesCross-sectional studySpecific screening testCase report formsColorectal Cancer StudyStudy participant characteristicsCross-sectional analysisStool testingCRC riskMortality outcomesColorectal cancerClinical trialsCONFIRM studyMedical CenterScreening preferencesHispanic ethnicity
2022
Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states
Lee M, Cosentino D, Kyriakides TC, Cavallaro T, Stack G, Gupta S. Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states. Journal Of Hospital Medicine 2022, 17: 534-538. PMID: 35661577, PMCID: PMC9348310, DOI: 10.1002/jhm.12852.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19FemaleHospitalizationHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2VaccinationVeteransConceptsCOVID-19Intensive care unit admissionVeterans Administration Healthcare SystemCare unit admissionNonpsychiatric hospitalizationsVirologic factorsFull vaccinationUnit admissionICU careClinical outcomesPoor outcomeMean ageRetrospective analysisD614G mutationHealthcare systemVeteransNew England statesHospitalizationOlder cohortOutcomesViral epidemiologyVaccinationDemographic factorsG mutationAge
2019
Employment Outcomes From VA Vocational Services Involving Transitional Work for Veterans With a Diagnosis of Posttraumatic Stress Disorder
Davis LL, Resnick SG, Maieritsch KP, Weber KC, Erbes CR, Strom TQ, McCall KP, Kyriakides TC. Employment Outcomes From VA Vocational Services Involving Transitional Work for Veterans With a Diagnosis of Posttraumatic Stress Disorder. Psychiatric Rehabilitation Journal 2019, 42: 257-267. PMID: 30945920, PMCID: PMC6910199, DOI: 10.1037/prj0000357.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderVeterans Health AdministrationStress disorderCompetitive employment outcomesStudy of veteransComparative subgroup analysisCompetitive jobsBaseline characteristicsSubgroup analysisHealth AdministrationYounger agePsychiatric disabilitiesTransitional workPotential subgroupsNonengagersOutcomesVeteransVocational rehabilitationAnalysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection
Ma R, Jung TH, Peduzzi PN, Brown ST, Kyriakides TC. Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2019, 18: 2325958219849101. PMID: 31272313, PMCID: PMC6748500, DOI: 10.1177/2325958219849101.Peer-Reviewed Original ResearchConceptsDrug changesCox proportional hazards regression modelKaplan-Meier survival techniqueMultidrug-resistant HIV infectionProportional hazards regression modelsAdvanced-stage AIDSDrug regimen changesSurvival of patientsHazards regression modelsAntiretroviral clinical trialsClinical biomarker dataCause mortalityMedication changesARV regimenHIV infectionImproved survivalRegimen changeClinical outcomesNonclinical reasonsClinical trialsBiomarker changesTreatment historyMultidrug resistanceTherapy strategiesPatients
2018
Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study
Ofori-Atta A, Reynolds NR, Antwi S, Renner L, Nichols JS, Lartey M, Amissah K, Tettey JK, Alhassan A, Ofori IP, Catlin AC, Gan G, Kyriakides TC, Paintsil E, Team O. Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study. AIDS Care 2018, 31: 283-292. PMID: 30360643, PMCID: PMC6382516, DOI: 10.1080/09540121.2018.1537463.Peer-Reviewed Original ResearchConceptsCaregivers of childrenCaregiver depressionCaregivers of HIVLow HIV knowledgeChild health outcomesCorrelates of depressionLow social supportPediatric HIVIllness perceptionsIntervention trialsMean ageHIV knowledgeRisk factorsSevere depressionHigh prevalenceHIV stigmaAdjusted modelHIVCaregiver statusHealth outcomesStudy participantsCaregiversPrevalenceDepressionSub-Saharan countriesHigh prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana
Nichols JS, Kyriakides TC, Antwi S, Renner L, Lartey M, Seaneke OA, Obeng R, Catlin AC, Gan G, Reynolds NR, Paintsil E, Team O. High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana. AIDS Care 2018, 31: 25-34. PMID: 30235940, PMCID: PMC6288009, DOI: 10.1080/09540121.2018.1524113.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART adherence ratesPediatric HIV carePrevalence of adherenceAntiretroviral medication adherenceCohort of childrenHIV-positive statusChildren of caregiversChild-caregiver dyadsHIV carePharmacy recordsRefill dataMedian adherenceMedication adherenceAdherence ratesPoor adherenceHigh prevalencePositive statusIntervention studiesHIVGood adherenceAdherenceBaseline dataChildrenTherapyEfficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial
Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE. Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial. AIDS And Behavior 2018, 23: 211-221. PMID: 30073637, PMCID: PMC6476298, DOI: 10.1007/s10461-018-2241-z.Peer-Reviewed Original ResearchConceptsHIV-positive patientsHeavy drinking daysVACS Index scoreXR-NTXART adherenceDrinking daysIndex scoreUndetectable HIV viral loadCD4 cell countExtended-release naltrexoneDouble-blind placeboHIV viral loadRandomized-controlled trialDrinking outcomesHIV biomarkersSecondary outcomesHIV outcomesPrimary outcomeViral loadAntiretroviral adherenceClinical trialsCell countAlcohol treatmentHIVPatientsEffect of Evidence-Based Supported Employment vs Transitional Work on Achieving Steady Work Among Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial
Davis LL, Kyriakides TC, Suris AM, Ottomanelli LA, Mueller L, Parker PE, Resnick SG, Toscano R, Scrymgeour AA, Drake RE. Effect of Evidence-Based Supported Employment vs Transitional Work on Achieving Steady Work Among Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2018, 75: 316-324. PMID: 29490371, PMCID: PMC5875356, DOI: 10.1001/jamapsychiatry.2017.4472.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderClinical trialsIPS groupIndividual PlacementVeterans Affairs Medical CenterCompetitive jobsStress disorderChronic posttraumatic stress disorderVocational rehabilitation interventionsVocational rehabilitationCompetitive employmentMore participantsTreat analysisMean ageMedical CenterMAIN OUTCOMERehabilitation interventionsMultisite trialLatino ethnicityIPS participantsSupported employment interventionTransitional workTrialsVeteransVeterans Individual Placement and Support Towards Advancing Recovery: Methods and Baseline Clinical Characteristics of a Multisite Study
Davis LL, Kyriakides TC, Suris A, Ottomanelli L, Drake RE, Parker PE, Mueller L, Resnick SG, Toscano R, Blansett CM, McCall KP, Huang GD. Veterans Individual Placement and Support Towards Advancing Recovery: Methods and Baseline Clinical Characteristics of a Multisite Study. Psychiatric Rehabilitation Journal 2018, 41: 55-66. PMID: 28358525, DOI: 10.1037/prj0000250.Peer-Reviewed Original ResearchConceptsTransitional work programPosttraumatic stress disorderVeterans Affairs Medical CenterUsual care practicesVeterans Affairs Cooperative Studies ProgramService-connected disabilityYears of ageTrial of IPSCooperative Studies ProgramCombat-related traumaMilitary sexual traumaBaseline characteristicsClinical characteristicsMedical CenterVeteran populationBaseline findingsOutcome criteriaRehabilitation servicesMultisite trialStress disorderPTSD populationsVocational rehabilitation servicesStudy sampleIndividual PlacementSexual trauma
2017
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
Powell J, Sweeting M, Ulug P, Blankensteijn J, Lederle F, Becquemin J, Greenhalgh R, , Greenhalgh R, Beard J, Buxton M, Brown L, Harris P, Powell J, Rose J, Russell I, Sculpher M, Thompson S, Lilford R, Bell P, Greenhalgh R, Whitaker S, Poole‐Wilson T, Ruckley C, Campbell W, Dean M, Ruttley M, Coles E, Powell J, Halliday A, Gibbs S, Brown L, Epstein D, Sculpher M, Thompson S, Hannon R, Johnston L, Bradbury A, Henderson M, Parvin S, Shepherd D, Greenhalgh R, Mitchell A, Edwards P, Abbott G, Higman D, Vohra A, Ashley S, Robottom C, Wyatt M, Rose J, Byrne D, Edwards R, Leiberman D, McCarter D, Taylor P, Reidy J, Wilkinson A, Ettles D, Clason A, Leen G, Wilson N, Downes M, Walker S, Lavelle J, Gough M, McPherson S, Scott D, Kessell D, Naylor R, Sayers R, Fishwick N, Harris P, Gould D, Walker M, Chalmers N, Garnham A, Collins M, Beard J, Gaines P, Ashour M, Uberoi R, Braithwaite B, Whitaker S, Davies J, Travis S, Hamilton G, Platts A, Shandall A, Sullivan B, Sobeh M, Matson M, Fox A, Orme R, Yusef W, Doyle T, Horrocks M, Hardman J, Blair P, Ellis P, Morris G, Odurny A, Vohra R, Duddy M, Thompson M, Loosemore T, Belli A, Morgan R, Adiseshiah M, Brookes J, McCollum C, Ashleigh R, Aukett M, Baker S, Barbe E, Batson N, Bell J, Blundell J, Boardley D, Boyes S, Brown O, Bryce J, Carmichael M, Chance T, Coleman J, Cosgrove C, Curran G, Dennison T, Devine C, Dewhirst N, Errington B, Farrell H, Fisher C, Fulford P, Gough M, Graham C, Hooper R, Horne G, Horrocks L, Hughes B, Hutchings T, Ireland M, Judge C, Kelly L, Kemp J, Kite A, Kivela M, Lapworth M, Lee C, Linekar L, Mahmood A, March L, Martin J, Matharu N, McGuigen K, Morris‐Vincent P, Murray S, Murtagh A, Owen G, Ramoutar V, Rippin C, Rowley J, Sinclair J, Spencer S, Taylor V, Tomlinson C, Ward S, Wealleans V, West J, White K, Williams J, Wilson L, Grobbee D, Blankensteijn J, Bak A, Buth J, Pattynama P, Verhoeven E, van Voorthuisen A, Blankensteijn J, Balm R, Buth J, Cuypers P, Grobbee D, Prinssen M, van Sambeek M, Verhoeven E, Baas A, Hunink M, van Engelshoven J, Jacobs M, de Mol B, van Bockel J, Balm R, Reekers J, Tielbeek X, Verhoeven E, Wisselink W, Boekema N, Heuveling L, Sikking I, Prinssen M, Balm R, Blankensteijn J, Buth J, Cuypers P, van Sambeek M, Verhoeven E, de Bruin J, Baas A, Blankensteijn J, Prinssen M, Buth J, Tielbeek A, Blankensteijn J, Balm R, Reekers J, van Sambeek M, Pattynama P, Verhoeven E, Prins T, van der Ham A, van der Velden J, van Sterkenburg S, ten Haken G, Bruijninckx C, van Overhagen H, Tutein Nolthenius R, Hendriksz T, Teijink J, Odink H, de Smet A, Vroegindeweij D, van Loenhout R, Rutten M, Hamming J, Lampmann L, Bender M, Pasmans H, Vahl A, de Vries C, Mackaay A, van Dortmont L, van der Vliet A, Schultze Kool L, Boomsma J, van Dop H, de Mol van Otterloo J, de Rooij T, Smits T, Yilmaz E, Wisselink W, van den Berg F, Visser M, van der Linden E, Schurink G, de Haan M, Smeets H, Stabel P, van Elst F, Poniewierski J, Vermassen F, Lederle F, Freischlag J, Kohler T, Latts E, Matsumura J, Padberg F, Kyriakides T, Swanson K, Guarino P, Peduzzi P, Antonelli M, Cushing C, Davis E, Durant L, Joyner S, Kossack T, Kyriakides T, LeGwin M, McBride V, O'Connor T, Poulton J, Stratton T, Zellner S, Snodgrass A, Thornton J, Swanson K, Haakenson C, Stroupe K, Jonk Y, Hallett J, Hertzer N, Towne J, Katz D, Karrison T, Matts J, Marottoli R, Kasl S, Mehta R, Feldman R, Farrell W, Allore H, Perry E, Niederman J, Randall F, Zeman M, Beckwith T, O'Leary T, Huang G, Latts E, Bader M, Ketteler E, Kingsley D, Marek J, Massen R, Matteson B, Pitcher J, Langsfeld M, Corson J, Goff J, Kasirajan K, Paap C, Robertson D, Salam A, Veeraswamy R, Milner R, Kasirajan K, Guidot J, Lal B, Busuttil S, Lilly M, Braganza M, Ellis K, Patterson M, Jordan W, Whitley D, Taylor S, Passman M, Kerns D, Inman C, Poirier J, Ebaugh J, Raffetto J, Chew D, Lathi S, Owens C, Hickson K, Dosluoglu H, Eschberger K, Kibbe M, Baraniewski H, Matsumura J, Endo M, Busman A, Meadows W, Evans M, Giglia J, El Sayed H, Reed A, Ruf M, Ross S, Jean‐Claude J, Pinault G, Kang P, White N, Eiseman M, Jones T, Timaran C, Modrall J, Welborn M, Lopez J, Nguyen T, Chacko J, Granke K, Vouyouka A, Olgren E, Chand P, Allende B, Ranella M, Yales C, Whitehill T, Krupski T, Nehler M, Johnson S, Jones D, Strecker P, Bhola M, Shortell C, Gray J, Lawson J, McCann R, Sebastian M, Kistler Tetterton J, Blackwell C, Prinzo P, Lee N, Padberg F, Cerveira J, Lal B, Zickler R, Hauck K, Berceli S, Lee W, Ozaki C, Nelson P, Irwin A, Baum R, Aulivola B, Rodriguez H, Littooy F, Greisler H, O'Sullivan M, Kougias P, Lin P, Bush R, Guinn G, Bechara C, Cagiannos C, Pisimisis G, Barshes N, Pillack S, Guillory B, Cikrit D, Lalka S, Lemmon G, Nachreiner R, Rusomaroff M, O'Brien E, Cullen J, Hoballah J, Sharp W, McCandless J, Beach V, Minion D, Schwarcz T, Kimbrough J, Ashe L, Rockich A, Warner‐Carpenter J, Moursi M, Eidt J, Brock S, Bianchi C, Bishop V, Gordon I, Fujitani R, Kubaska S, Behdad M, Azadegan R, Ma Agas C, Zalecki K, Hoch J, Carr S, Acher C, Schwarze M, Tefera G, Mell M, Dunlap B, Rieder J, Stuart J, Weiman D, Abul‐Khoudoud O, Garrett H, Walsh S, Wilson K, Seabrook G, Cambria R, Brown K, Lewis B, Framberg S, Kallio C, Barke R, Santilli S, d'Audiffret A, Oberle N, Proebstle C, Johnson L, Jacobowitz G, Cayne N, Rockman C, Adelman M, Gagne P, Nalbandian M, Caropolo L, Pipinos I, Johanning J, Lynch T, DeSpiegelaere H, Purviance G, Zhou W, Dalman R, Lee J, Safadi B, Coogan S, Wren S, Bahmani D, Maples D, Thunen S, Golden M, Mitchell M, Fairman R, Reinhardt S, Wilson M, Tzeng E, Muluk S, Peterson N, Foster M, Edwards J, Moneta G, Landry G, Taylor L, Yeager R, Cannady E, Treiman G, Hatton‐Ward S, Salabsky T, Kansal N, Owens E, Estes M, Forbes B, Sobotta C, Rapp J, Reilly L, Perez S, Yan K, Sarkar R, Dwyer S, Perez S, Chong K, Kohler T, Hatsukami T, Glickerman D, Sobel M, Burdick T, Pedersen K, Cleary P, Back M, Bandyk D, Johnson B, Shames M, Reinhard R, Thomas S, Hunter G, Leon L, Westerband A, Guerra R, Riveros M, Mills J, Hughes J, Escalante A, Psalms S, Day N, Macsata R, Sidawy A, Weiswasser J, Arora S, Jasper B, Dardik A, Gahtan V, Muhs B, Sumpio B, Gusberg R, Spector M, Pollak J, Aruny J, Kelly E, Wong J, Vasilas P, Joncas C, Gelabert H, DeVirgillio C, Rigberg D, Cole L, Becquemin J, Marzelle J, Becquemin J, Sapoval M, Becquemin J, Favre J, Watelet J, Lermusiaux P, Sapoval M, Lepage E, Hemery F, Dolbeau G, Hawajry N, Cunin P, Harris P, Stockx L, Chatellier G, Mialhe C, Fiessinger J, Pagny L, Kobeiter H, Boissier C, Lacroix P, Ledru F, Pinot J, Deux J, Tzvetkov B, Duvaldestin P, Watelet J, Jourdain C, David V, Enouf D, Ady N, Krimi A, Boudjema N, Jousset Y, Enon B, Blin V, Picquet J, L'Hoste P, Thouveny F, Borie H, Kowarski S, Pernes J, Auguste M, Becquemin J, Desgranges P, Allaire E, Marzelle J, Kobeiter H, Meaulle P, Chaix D, Juliae P, Fabiani J, Chevalier P, Combes M, Seguin A, Belhomme D, Sapoval M, Baque J, Pellerin O, Favre J, Barral X, Veyret C, Watelet J, Peillon C, Plissonier D, Thomas P, Clavier E, Lermusiaux P, Martinez R, Bleuet F, C D, Verhoye J, Langanay T, Heautot J, Koussa M, Haulon S, Halna P, Destrieux L, Lions C, Wiloteaux S, Beregi J, Bergeron P, Pinot J, Patra P, Costargent A, Chaillou P, D'Alicourt A, Goueffic Y, Cheysson E, Parrot A, Garance P, Demon A, Tyazi A, Pillet J, Lescalie F, Tilly G, Steinmetz E, Favier C, Brenot R, Krause D, Cercueil J, Vahdat O, Sauer M, Soula P, Querian A, Garcia O, Levade M, Colombier D, Cardon J, Joyeux A, Borrelly P, Dogas G, Magnan P, Branchereau A, Bartoli J, Hassen‐Khodja R, Batt M, Planchard P, Bouillanne P, Haudebourg P, Bayne J, Gouny P, Badra A, Braesco J, Nonent M, Lucas A, Cardon A, Kerdiles Y, Rolland Y, Kassab M, Brillu C, Goubault F, Tailboux L, Darrieux H, Briand O, Maillard J, Varty K, Cousins C. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. British Journal Of Surgery 2017, 104: 166-178. PMID: 28160528, PMCID: PMC5299468, DOI: 10.1002/bjs.10430.Peer-Reviewed Original ResearchConceptsElective endovascular aneurysm repairEarly survival advantageEVAR groupOpen repairIndividual patient dataAbdominal aortic aneurysmSurvival advantageEVAR-1Artery diseaseAortic aneurysmPrevious coronary artery diseaseBrachial pressure indexModerate renal dysfunctionPeripheral artery diseaseCoronary artery diseaseEndovascular aneurysm repairPrespecified analysis planOperative mortalityRenal dysfunctionAneurysm repairEarly mortalityACE trialLower ankleLower mortalityMortality advantage
2016
Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm: A Randomized Clinical Trial
Lederle FA, Stroupe KT, Kyriakides TC, Ge L, Freischlag JA. Long-term Cost-effectiveness in the Veterans Affairs Open vs Endovascular Repair Study of Aortic Abdominal Aneurysm: A Randomized Clinical Trial. JAMA Surgery 2016, 151: 1139-1144. PMID: 27627802, DOI: 10.1001/jamasurg.2016.2783.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmOpen repair groupEndovascular repairHealth care costsClinical trialsEndovascular groupRepair groupTotal mean health care costsCare costsVeterans Affairs Medical CenterMean health care costsEndovascular repair proceduresInitial endovascular repairAortic abdominal aneurysmQuality of lifeHealth care servicesElective repairClinical outcomesInitial repairShorter hospitalizationAbdominal aneurysmSecondary proceduresAortic aneurysmMAIN OUTCOMEMedical CenterCharacterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study
Helou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA. Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2016, 16: 261-266. PMID: 27903948, PMCID: PMC5423832, DOI: 10.1177/2325957416680028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedViral LoadViremiaConceptsVirologic failureViral load levelsPill burdenAlcohol useHuman immunodeficiency virus (HIV) careLow-level HIV viremiaUndetectable viral load levelsAntiretroviral regimen changesAntiretroviral therapy changesExperienced virologic failureLow-level viremiaIntravenous drug useSubset of patientsFrequent clinic visitsPoor clinical outcomePossible risk factorsHepatitis C virusHIV viremiaMore comorbiditiesNonfailure groupVirologic suppressionVirological failureCD4 countConsecutive chartsClinic visits
2015
Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms
Lal BK, Zhou W, Li Z, Kyriakides T, Matsumura J, Lederle FA, Freischlag J, Group O. Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms. Journal Of Vascular Surgery 2015, 62: 1394-1404. PMID: 26598115, DOI: 10.1016/j.jvs.2015.02.003.Peer-Reviewed Original ResearchConceptsType II endoleakEndovascular repairSecondary interventionsAortic aneurysmRisk factorsAneurysm sizeVeterans AffairsKaplan-Meier survival analysisInitial aneurysm sizeStandard-risk patientsSuccessful endovascular repairType of endoleakVascular risk factorsInfrarenal aortic aneurysmLong-term outcomesAnalysis of patientsLength of survivalAbdominal aortic aneurysmPresence of endoleaksLogistic regression analysisDiameter enlargementOVER trialPatient demographicsEndoleak developmentLong followTrends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011
Cowell A, Shenoi SV, Kyriakides TC, Friedland G, Barakat LA. Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011. Journal Of Hospital Medicine 2015, 10: 608-614. PMID: 26130520, PMCID: PMC4560992, DOI: 10.1002/jhm.2409.Peer-Reviewed Original ResearchConceptsHospital deathAIDS deathsHuman immunodeficiency virus-infected patientsHigher CD4 cell countsAIDS infectionAntiretroviral therapy eraNon-AIDS deathsNon-AIDS malignanciesCD4 cell countHIV viral loadVirus-infected patientsHuman immunodeficiency virusUrban teaching hospitalTimes greater likelihoodCardiovascular comorbiditiesTherapy eraCD4 countInpatient mortalityImmunodeficiency syndromeLiver diseaseUnderlying liverViral loadImmunodeficiency virusMedical recordsAntiretroviral eraElevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress
Koutsoulidou A, Kyriakides TC, Papadimas GK, Christou Y, Kararizou E, Papanicolaou EZ, Phylactou LA. Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress. PLOS ONE 2015, 10: e0125341. PMID: 25915631, PMCID: PMC4411125, DOI: 10.1371/journal.pone.0125341.Peer-Reviewed Original ResearchConceptsDM1 patientsMuscle-specific miRNAsMuscle wastingNatural historySensitive blood biomarkersPotential future therapiesDisease natural historyMyotonic dystrophy patientsAdult-onset muscular dystrophyMyotonic dystrophy type 1Useful molecular biomarkersParticipant seraSerum levelsMuscle weaknessBlood biomarkersClinical conditionsMuscle atrophyFuture therapiesPatientsPotential biomarkersDystrophy patientsMiR-133aType 1Progressive muscleMolecular biomarkers
2012
Predictive value of HIV‐1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment‐experienced patients
Bedimo R, Kyriakides T, Brown S, Weidler J, Lie Y, Coakley E, Holodniy M. Predictive value of HIV‐1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment‐experienced patients. HIV Medicine 2012, 13: 345-351. PMID: 22276745, DOI: 10.1111/j.1468-1293.2011.00981.x.Peer-Reviewed Original ResearchConceptsCD4 cell countViral load changesWeek 12Replication capacityPredictive valueCell countCD4 cell count responseHIV-1 replication capacityAntiretroviral treatment responseHIV replication capacityImmediate salvage therapyPhenotypic susceptibility scoresDrug-free periodPhenotypic resistance testingCell count responseAdditional predictive valueMultivariate regression analysisTreatment reinitiationSalvage therapyWeek 24ARV therapyViral loadPrognostic valueARV treatmentAntiretroviral trials
2011
Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial
Holodniy M, Brown ST, Cameron DW, Kyriakides TC, Angus B, Babiker A, Singer J, Owens DK, Anis A, Goodall R, Hudson F, Piaseczny M, Russo J, Schechter M, Deyton L, Darbyshire J, . Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial. PLOS ONE 2011, 6: e14764. PMID: 21483491, PMCID: PMC3069000, DOI: 10.1371/journal.pone.0014764.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsDrug Resistance, Multiple, ViralFemaleHIV InfectionsHumansMaleMiddle AgedConceptsRe-treatment optionsART interruptionHIV infectionPrimary outcomeRetreatment optionsMultidrug resistanceAdvanced HIV diseaseAntiretroviral treatment interruptionARV treatment failurePrior AIDS diagnosisResistant HIV InfectionMedian CD4 countPrimary composite outcomeSerious adverse eventsMean viral loadBest medical managementOPTIMA trialCD4 countOpen labelTreatment interruptionAdverse eventsComposite outcomeFirst AIDSHIV diseaseAntiretroviral treatmentEffect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV
Joyce VR, Barnett PG, Chow A, Bayoumi AM, Griffin SC, Sun H, Holodniy M, Brown ST, Kyriakides TC, Cameron DW, Youle M, Sculpher M, Anis AH, Owens DK. Effect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV. Medical Decision Making 2011, 32: 70-82. PMID: 21383086, DOI: 10.1177/0272989x10397615.Peer-Reviewed Original ResearchConceptsVisual analog scaleHIV patientsART intensificationTreatment interruptionClinical eventsMedical Outcomes Study HIV Health SurveyAdvanced HIV patientsAntiretroviral therapy interruptionMultiple treatment failuresTemporary treatment interruptionAdverse clinical eventsHealth-related qualityStandard ARTHealth Utilities IndexStandard gambleQuality of lifeAdvanced HIVART interruptionInferior HRQoLMDR HIVTherapy interruptionAntiretroviral therapyHIV cohortOpen labelHRQoL scores
2010
Connection Domain Mutations in Treatment-Experienced Patients in the OPTIMA Trial
Dau B, Ayers D, Singer J, Harrigan PR, Brown S, Kyriakides T, Cameron DW, Angus B, Holodniy M. Connection Domain Mutations in Treatment-Experienced Patients in the OPTIMA Trial. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 54: 160-166. PMID: 20130473, DOI: 10.1097/qai.0b013e3181cbd235.Peer-Reviewed Original ResearchConceptsTreatment-naive populationTreatment-experienced patientsCD mutationsTreatment-experienced populationsHIV viral loadConnection domainConnection domain mutationsOPTIMA trialVirologic outcomesVirologic responseARV regimenARV therapyViral loadAntiretroviral drugsAntiretroviral trialsUnivariate analysisDiminished responseFrequency of mutationsMultivariate analysisPatientsReduced susceptibilityA371VDomain mutationsResistance phenotypeTrials